Free Zinc as a Predictive Marker for COVID-19 Mortality Risk

Nutrients, Journal Year: 2022, Volume and Issue: 14(7), P. 1407 - 1407

Published: March 28, 2022

Free zinc is considered to be the exchangeable and biological active form of in serum, discussed a suitable biomarker for alterations body homeostasis related diseases. Given that coronavirus disease 2019 (COVID-19) characterized by marked decrease total serum zinc, clinical data indicate status impacts susceptibility severity infection, we hypothesized free might altered response SARS-CoV-2 infection may reflect severity. To test this hypothesis, concentrations samples survivors nonsurvivors COVID-19 were analyzed fluorometric microassay. Similar reported deficit measured reflection X-ray fluorescence, patients was considerably lower than control subjects, surviving displayed significantly higher levels those (mean ± SD; 0.4 0.2 nM vs. 0.1 nM; p = 0.0004). In contrast recovering (r 0.706, < 0.001) or declining copper−zinc ratio −0.646; 0.001), remained unaltered with time nonsurvivors. particularly low male as compared female 0.0003). This particular interest, sex described risk factor severe COVID-19. Overall, results depressed are associated increased death COVID-19, suggesting serve novel prognostic marker course

Language: Английский

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Zinc and Respiratory Viral Infections: Important Trace Element in Anti-viral Response and Immune Regulation

Biological Trace Element Research, Journal Year: 2021, Volume and Issue: 200(6), P. 2556 - 2571

Published: Aug. 9, 2021

Language: Английский

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Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond

TURKISH JOURNAL OF MEDICAL SCIENCES, Journal Year: 2021, Volume and Issue: 51(SI-1), P. 3312 - 3326

Published: Sept. 19, 2021

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has alarmed the world since its first emergence. As pregnancy is characterized significant changes in cardiovascular, respiratory, endocrine, and immunological systems, there are concerns on issues like course of pregnant women, safety medications, route delivery risk obstetric complications. The aim this review to summarize current literature management women during COVID-19 pandemic. Although more than 90% with recover without serious morbidity, rapid deterioration higher rates complications may be observed. vertical transmission not been clearly revealed yet. Decreasing number prenatal visits, shortening time allocated for examinations, active use telemedicine services, limiting persons healthcare settings, combining tests same visit, restricting visitors providing a safe environment facilities, strict hygiene control, personal protective equipment visits main strategies control spread according guidelines. new medication alternatives being proposed every day treatment COVID-19, our knowledge about most these drugs limited. Preliminary results promising administration SARS-CoV-2 vaccines population. Timing should decided based maternal health condition, accompanying gestational age. Cesarean performed indications. Breast feeding encouraged as long necessary precautions viral taken. In conclusion, an individualized approach provided multidisciplinary team achieve favorable outcomes.

Language: Английский

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Zinc deficiency as a possible risk factor for increased susceptibility and severe progression of Corona Virus Disease 19

British Journal Of Nutrition, Journal Year: 2021, Volume and Issue: 127(2), P. 214 - 232

Published: March 1, 2021

Abstract The importance of Zn for human health becomes obvious during deficiency. Even mild insufficiencies cause alterations in haematopoiesis and immune functions, resulting a proinflammatory phenotype disturbed redox metabolism. Although system malfunction has the most effect, functions several tissue cell types are if supply is limiting. Adhesion molecules tight junction proteins decrease, while death increases, generating barrier dysfunction possibly organ failure. Taken together, deficiency both weakens resistance body towards pathogens at same time increases danger an overactive response that may damage. case numbers Corona Virus Disease 19 (COVID-19) still increasing, which causing enormous problems systems economies. There urgent need to reduce number severe cases deaths. While therapeutic options under investigation, first vaccines have been approved, cost-effective ways likelihood or even prevent infection, transition from symptoms more serious detrimental disease, highly desirable. Nutritional supplementation might be effective option achieve these aims. In this review, we discuss known effects context infection with Severe Acute Respiratory Syndrome-Coronavirus-2 its currently pathogenic mechanisms elaborate on how pre-existing pre-dispose patients progression COVID-19. First published clinical data association homoeostasis COVID-19 registered studies progress listed.

Language: Английский

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Impact of COVID-19 during pregnancy on placental pathology, maternal and neonatal outcome – A cross-sectional study on anemic term pregnant women from a tertiary care hospital in southern India

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: March 21, 2023

SARS-CoV-2 infection during pregnancy may cause adverse maternal, neonatal and placental outcomes. While tissue hypoxia is often reported in COVID-19 patients, pregnant women with anemia are suspected to be more prone hypoxia-related injuries.

Language: Английский

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Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study

Nutrients, Journal Year: 2021, Volume and Issue: 13(10), P. 3578 - 3578

Published: Oct. 13, 2021

Copper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels copper/zinc (Cu/Zn) ratio its association with nutritional indicators in a series of children adolescents chronic diseases. Anthropometric, biochemical, dietary, body composition, bone densitometry assessments were carried out. Serum Zn measured by atomic absorption spectrophotometry. Seventy-eight patients (55% women) participated. The mean the entire status through mass index (BMI) normal. decreased significantly age meaningfully higher than adolescents. risk finding altered men women, respectively. Twenty-two per cent had abnormal copper levels, 13 hypercupremia, four hypocupremia. Cu/Zn greater 1.00 87% patients, which indicator inflammatory state. All hypozincemia hypocupremia deficient intake, but only 65% hypercupremia dietary deficiency. Consequently, could indicate state high zinc deficiency this specific child population.

Language: Английский

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Gustatory and Saliva Secretory Dysfunctions in COVID-19 Patients with Zinc Deficiency

Life, Journal Year: 2022, Volume and Issue: 12(3), P. 353 - 353

Published: Feb. 28, 2022

Given the ever-progressing studies on coronavirus disease 2019 (COVID-19), it is critical to update our knowledge about COVID-19 symptomatology and pathophysiology. In present narrative review, oral symptoms were overviewed using latest data their pathogenesis was hypothetically speculated. PubMed, LitCovid, ProQuest, Google Scholar searched for relevant from 1 April 2021 with a cutoff date of 31 January 2022. The literature search indicated that gustatory dysfunction saliva secretory are prevalent in patients both dysfunctions persist after recovery disease, suggesting pathogenic mechanism common these cooccurring symptoms. characterized by hypozincemia, which zinc possibly redistributed blood liver at expense other tissues. If induces intracellular deficiency, activity zinc-metalloenzyme carbonic anhydrase localized taste buds salivary glands may be influenced adversely affect functions. Zinc-binding metallothioneins transporters, cooperatively control cellular homeostasis, expressed tissues participating secretion. Their expression dysregulation associated COVID-19-induced deficiency have some effect Zinc supplementation expected improve patients.

Language: Английский

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Nutrition as Personalized Medicine against SARS-CoV-2 Infections: Clinical and Oncological Options with a Specific Female Groups Overview

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(16), P. 9136 - 9136

Published: Aug. 15, 2022

Coronavirus disease 2019 (COVID-19) is a respiratory caused by severe acute syndrome coronavirus-2 (SARS-CoV-2). It acknowledged that vulnerable people can suffer from mortal complications of COVID-19. Therefore, strengthening the immune system particularly in most fragile could help to protect them infection. First, general nutritional status and food consumption patterns everyone affect effectiveness each system. The effects nutrition impact level intestinal genital microbiota, adaptive system, innate Indeed, cells mediators, which are crucial inflammatory reaction, structures fats, carbohydrates, proteins activated through vitamins (vit) minerals. association malnutrition infection damage response, reducing amplifying mediators. Both amount type dietary fat on cytokine biology, consequently assumes role disease. This review explores power response against COVID-19 infection, since specific diet modify storm during phase. be vital importance subjects such as pregnant women or cancer patients whom we have deemed it necessary dedicate personalized indications.

Language: Английский

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Preparation and activity study of Ruoqiang jujube polysaccharide copper chelate

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 11, 2024

Background: Polysaccharide metal chelate exhibit both immunoregulatory activity and element supplementation effects. Methods: In this study, Ruoqiang jujube polysaccharide copper (RJP-Cu) was prepared the preparation conditions were optimized using response surface method. Subsequently, RJP-Cu administered to lambs evaluate its impact on growth performance, ion (Cu 2+ ) supplementation, immune enhancement, intestinal flora evaluated. Results: The results indicated that optimal chelation included a sodium citrate content of 0.5 g, reaction temperature 50°C, solution pH 8.0, resulting in Cu concentration 583°mg/kg RJP-Cu. Scanning electron microscopy (SEM) revealed significant structural changes RJP before after chelation. displaying characteristic peaks polysaccharides chelates. Blood routine indexes showed no differences among RJP-Cu-High dose group (RJP-Cu-H), RJP-Cu-Medium (RJP-Cu-M), RJP-Cu-low (RJP-Cu-L) control ( p &gt; 0.05). However, compared with group, RJP-Cu-H, M, L groups significantly enhanced lamb production performance &lt; Furthermore, increased serum concentration, total antioxidant capacity (T-AOC), catalase (CAT), superoxide dismutase (T-SOD) contents RJP-Cu-H exhibited increases IgA IgG antibodies, as well secretion cytokines IL-2, IL-4, TNF-α (p species abundance microbiota, quantity beneficial bacteria, decrease harmful bacteria. led promotion synthesis various Short Chain Fatty Acids (SCFAs), improvements atrazine degradation clavulanic acid biosynthesis lambs, while reducing cell apoptosis lipopolysaccharide biosynthesis. Conclusion: Thus, these findings demonstrate RJP-Cu, chelate, could effectively promote increase content, potentially induce positive immunomodulatory effects by regulating enzymes, cytokines, flora, related metabolic pathways.

Language: Английский

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Association between dietary magnesium intake, inflammation, and neurodegeneration

European Journal of Nutrition, Journal Year: 2024, Volume and Issue: 63(5), P. 1807 - 1818

Published: April 10, 2024

Consistent evidence shows that magnesium (Mg) intake is associated with lower blood pressure (BP), and BP improved cerebral health. However, recent findings indicate the positive effect of dietary Mg on health not mediated by a decrease in BP. As Mg's anti-inflammatory action plausible alternative mechanism, objective this study was to investigate associations between inflammation determine whether it mediates any neuroprotective effect.

Language: Английский

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