Unveiling the impacts of microplastics on cadmium transfer in the soil-plant-human system: A review

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 477, P. 135221 - 135221

Published: July 18, 2024

Language: Английский

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Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(9), P. 1011 - 1017

Published: March 5, 2024

With continuous population and economic growth in the 21

Language: Английский

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Polystyrene nanoplastics exacerbate aflatoxin B1-induced hepatic injuries by modulating the gut−liver axis

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 935, P. 173285 - 173285

Published: May 19, 2024

Language: Английский

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Co-exposure of polyvinyl chloride microplastics with cadmium promotes nonalcoholic fatty liver disease in female ducks through oxidative stress and glycolipid accumulation

Poultry Science, Journal Year: 2024, Volume and Issue: 103(11), P. 104152 - 104152

Published: Aug. 5, 2024

A recently discovered environmental contaminant, microplastics (MPs) are capable of amassing within the body and pose a grave threat to health both humans animals. It is widely acknowledged that combination cadmium (Cd), hazardous heavy metal, produces synergistic deleterious effects. Nevertheless, mechanism by which co-exposure polyvinyl chloride (PVC-MPs) Cd damages liver avian females unknown. Globally prevalent subject extensive research in mammals, non-alcoholic fatty disease (NAFLD) chronic condition. However, mechanisms underlying injury digestive system caused NAFLD remain Two months PVC-MPs, pure water, solitary exposure, single water were administered female Muscovy ducks this study. The objective was examine whether duck PVC-MPs Cd-induced oxidative stress resulted subsequent apoptosis hepatic cells. study's findings showed hepatocyte shape functional activity negatively impacted PVC-MP buildup tissues. Reduced organ coefficients, increased alanine aminotransferase (ALT) content, ultrastructural damage nuclei mitochondria indicators this. These results point possible impairment function. phosphoenolpyruvate carboxykinase 1 (PCK1) deficiency activates protein kinase B/phosphatidylinositol 3-kinase (PI3K/AKT) pathway livers reproductive have been damaged stress. This stimulation induces lipid deposition, fibrosis, glycogen accumulation, ultimately apoptosis. In summary, our provides evidence cause harm liver, subsequently fibrosis tissue, glucolipid metabolism,

Language: Английский

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Impact of polyvinyl chloride microplastic and paraquat herbicide on the blood cells, biochemical parameters, liver enzymes and morphological changes of aqueduct fish

Chemosphere, Journal Year: 2024, Volume and Issue: 362, P. 142643 - 142643

Published: June 19, 2024

Language: Английский

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Micro/nano plastics in the urinary system: Pathways, mechanisms, and health risks

Environment International, Journal Year: 2024, Volume and Issue: 193, P. 109109 - 109109

Published: Nov. 1, 2024

Micro/Nano plastics (MNPs) pollutants are widespread in the environment, raising significant concerns about their biosafety. Emerging studies indicate that urinary system is a primary accumulation site for MNPs, leading to severe tissue and functional damage. This review aims summarize recent research on potential hazards MNPs may pose system, highlighting mechanisms of toxicity current state knowledge. Studies have shown enter human body through drinking water, food chain, inhalation, skin contact. They penetrate bloodstream via digestive, respiratory, systems, subsequently dispersing various organs, including system. The might induce cellular oxidative stress, inflammation, apoptosis, autophagy, "intestine-kidney axis", other possible toxic mechanisms. These processes could disrupt kidney metabolic functions promote fibrosis, thereby potentially increasing risk diseases. Despite ongoing research, understanding MNPs' impact remains limited. Therefore, this provides comprehensive overview highlights key challenges, outlines future directions. It offers theoretical basis development effective protective measures policies.

Language: Английский

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Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases

Molecular & Cellular Toxicology, Journal Year: 2025, Volume and Issue: 21(2), P. 387 - 397

Published: Feb. 27, 2025

Given the global increase in obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) is a major health concern. Because primary organ for xenobiotic metabolism, impact of environmental stressors on homeostasis and MASLD has garnered significant interest over past few decades. The concept metabolism-disrupting chemicals (MDCs) been introduced to underscore importance factors homeostasis. Recent epidemiological biological studies suggest causal link between exposure MDCs prevalence progression MASLD. This review aims introduce emerging their representative toxic mechanisms. In particular, this focuses broadening understanding impacts or steatohepatitis (MASH) progression. research highlighted contaminants, such as heavy metals, microplastics, pesticides, have potential influence hepatic metabolism aggravate MASLD/MASH These not only directly affect lipid hepatocytes but also other cell types, immune cells stellate cells, well gut-liver axis. Collectively, these findings contribute establishing well-defined adverse outcome pathway identify novel therapeutic options diseases associated with pollutants.

Language: Английский

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Synergistic Human Health Risks of Microplastics and Co-Contaminants: A Quantitative Risk Assessment in Water

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 491, P. 137809 - 137809

Published: March 5, 2025

Language: Английский

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New insights into heavy metal cadmium-induced liver injury: prominent role of programmed cell death mechanisms

Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 154169 - 154169

Published: May 1, 2025

Language: Английский

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Systemic toxicity of biodegradable polyglycolic acid microplastics on the gut-liver-brain axis in zebrafish

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 954, P. 176898 - 176898

Published: Oct. 12, 2024

Language: Английский

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