Association of inflammation-mediated blood heavy metals with plasma atherogenic index: NHANES analysis 2015-2020 DOI Creative Commons

xue Wang,

Ming Zhang

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 27, 2023

Abstract Heavy metal pollutants are widely present in a variety of environments, and several studies have shown that exposure to heavy metals is associated with the risk atherosclerosis. However, underlying mechanism this association remains unclear.AIP, as biomarker for predicting cardiovascular events, can reflect atherosclerosis severity blood vessel stenosis. Therefore, explore relationship between single combined plasma index. The study included data from 2015–2016 2017–2020 National Health Nutrition Examination Surveys (NHANES) assessed mediating role inflammation adults. In model, positive dose-response was observed selenium (Se) AIP, negative correlation cadmium (Cd) mercury (Hg) AIP. We construct weighted quantile sum (WQS) regression Bayesian kernel machine (BKMR).In WQS AIP increased significantly increase concentration mixed metals, while BKMR results were consistent, statistical significance. addition, mediated analysis showed HS-CRP-mediated elevations 11.83% selenium-associated indicated caused an inflammatory response aggravated progression.

Language: Английский

Association between serum copper and blood glucose: a mediation analysis of inflammation indicators in the NHANES (2011–2016) DOI Creative Commons
Zijing Cheng, Yuzhe Kong,

Wenqi Yang

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: May 24, 2024

Background The rising prevalence of diabetes underscores the need for identifying effective prevention strategies. Recent research suggests environmental factors, particularly heavy metals like copper, significantly influence health outcomes, including diabetes, through mechanisms involving inflammation and oxidative stress. This study aims to explore how serum copper levels affect blood glucose, employing NHANES data from 2011 2016, provide insights into health’s role in management. Methods analyzed 2,318 participants across three cycles (2011–2016), focusing on those with available inflammatory markers, glucose levels. We utilized principal component analysis selecting mediation examine direct indirect effects, multiple linear regression assessing relationships between markers levels, weighted quantile sum evaluating individual collective marker adjusting demographic variables copper. Results Participants averaged 42.70 years age, a near-even split genders. Average was 119.50 μg/dL, white cell count 6.82 × 109/L, fasting 107.10 mg/dL. Analyses identified significant by (especially cells: 39.78%) copper-blood relationship. Regression analyses highlighted positive correlation cells (estimate: 1.077, 95% CI: 0.432 2.490, p = 0.013) negative monocyte percentage −1.573, 0.520 −3.025, 0.003). Neutrophil notably influential Sensitive confirmed study’s findings. Conclusion Serum impact mediation, highlighting importance considering factors management prevention. These findings advocate public interventions policies targeting monitoring metal exposure reduction, emphasizing potential measures combating incidence.

Language: Английский

Citations

11
Associations between serum metal mixtures and systemic inflammation indices among Chinese early adolescents: A prospective cohort study DOI Creative Commons
Yonghan Li,

B. Huang,

Mengyuan Yuan

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117952 - 117952

Published: Feb. 26, 2025

Language: Английский

Citations

1
Heavy metal levels and flavonoid intakes are associated with chronic obstructive pulmonary disease: an NHANES analysis (2007–2010 to 2017–2018) DOI Creative Commons
Zhaoqi Yan, Yifeng Xu,

Keke Li

et al.

BMC Public Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 24, 2023

Abstract Background The association between exposure to environmental metals and chronic obstructive pulmonary disease (COPD) is preventing lung diseases. However, little currently known about the interaction heavy flavonoids in relation risk of COPD. This study aims bridge this knowledge gap by leveraging National Health Nutrition Examination Survey (NHANES) database evaluate thecorrelation blood levels (cadmium, lead, mercury) intake various flavonoid compounds (isoflavones, anthocyanidins, flavan-3-ols, flavanones, flavones, flavonols, total flavonoids). Additionally, appropriate dietary recommendations are provided based on findings. Materials methods Cross-sectional analysis was conducted using 2007–2010 2017–2018 NHANES data. Specialized weighted complex survey design software used for data analysis. Multivariate logistic regression models restricted cubic splines (RCS) were relationship metal levels, intake, COPD incidence all participants, explore effect different caused exposure. Results A 7,265 adults aged ≥ 40 years analyzed. Higher cadmium (Cd), lead Anthocyanidin (AC) independently associated with an increased (Cd highest quantile vs. lowest: OR = 1.73, 95% CI, 1.25–2.3; Lead lowest quantile: 1.44, 1.11–1.86; AC 0.73, 0.54–0.99). When exceeded 11.56 mg/d, Cd decreased 27%, finding more significant smokers. Conclusion (≥ 0.45ug/L) 0.172 ug/L) positively correlated among participants above, while mg/d) could reduce related Cd.

Language: Английский

Citations

11
The single and mixed impacts of cadmium, cobalt, lead, and PAHs on systemic immunity inflammation index in male and female DOI Creative Commons
Jun-feng Nie,

Zhumin Hu,

Cuiyao Xian

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 15, 2024

Studies on the association between mixed exposure to common pollutants such as cadmium (Cd), cobalt (Co), lead (Pb), and polycyclic aromatic hydrocarbons (PAHs) with Systemic Immune Inflammatory Index (SII), a novel hemocyte-based inflammatory marker, have not been reported. This study explored relationship co-exposure Cd, Co, Pb, PAHs, SII.

Language: Английский

Citations

3
Association between heavy metals exposure and persistent infections: the mediating role of immune function DOI Creative Commons

Huiling Zhang,

Juan Wang, Kunlun Zhang

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: July 22, 2024

Persistent infections caused by certain viruses and parasites have been associated with multiple diseases substantial mortality. Heavy metals are ubiquitous environmental pollutants immunosuppressive properties. This study aimed to determine whether heavy exposure suppress the immune system, thereby increasing susceptibility persistent infections.

Language: Английский

Citations

3
Associations of occupational exposure to micro-LiNiCoMnO2 particles with systemic inflammation and cardiac dysfunction in cathode material production for lithium batteries DOI Creative Commons

Yaotang Deng,

G Z Li, Lijie Xie

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 359, P. 124694 - 124694

Published: Aug. 9, 2024

Micro-LiNiCoMnO

Language: Английский

Citations

2
Association of Metal Exposure with Novel Immunoinflammatory Indicators DOI Creative Commons
Lingxiao Zhao, Xieyi Chen, Zhongwen Chen

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(5), P. 316 - 316

Published: April 26, 2024

Objective: We aimed to investigate the relationship between metal exposure and novel immunoinflammatory indicators. Methods: Data on adults participating in National Health Nutrition Examination Survey (NHANES) from 2009 2018 were analyzed. Various statistical models employed assess association immune-inflammation-related Additionally, impact of inflammation different gender populations was explored. Results: This study included 4482 participants, whom 51.1% male. Significant correlations observed among various metals. Both elastic net (ENET) linear regression revealed robust associations cadmium (Cd), cobalt (Co), arsenic (As), mercury (Hg), Weighted quantile sum (WQS) Quantile g-computation (Q-gcomp) demonstrated strong barium (Ba), Co, Hg Bayesian kernel machine (BKMR) analysis indicated an overall positive correlation vivo urinary levels systemic response index (SIRI) aggregate (AISI). Furthermore, As, emerged as key metals contributing changes Conclusions: Metals exhibit with emerging indicators, concurrent mixed may exacerbate inflammatory response. this varies across populations.

Language: Английский

Citations

1
Environmental factors in the development of Coronary Artery Atherosclerosis DOI

Ifrah Siddiqui,

Fatima Ahmad,

Nabeel Ahmad Khan

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Abstract Objective: This study aims to comprehensively investigate the role of environmental factors—diet, physical activity, tobacco smoke, air pollution, psychosocial factors, occupational exposures, noise climate urbanization, and socioeconomic status—in pathogenesis coronary artery disease (CAD). Background: Coronary (CAD) poses a significant global health challenge influenced by complex interplay environmental, behavioral, factors. These factors contribute inflammation, endothelial dysfunction, atherosclerosis, plaque rupture, thrombosis, underscoring need for holistic understanding inform effective preventive therapeutic strategies. Methods: A systematic review was conducted across PubMed, MEDLINE, Google Scholar, various journals identify relevant studies on CAD. The search encompassed articles without date restrictions, adhering PRISMA guidelines. Studies exploring causal links between CAD pathophysiology were included, with data synthesized elucidate key mechanisms relationships. Results: investigation highlights connections pathophysiology. Diets high in saturated fats sugars exacerbate inflammation while diets rich antioxidants omega-3 fatty acids mitigate these effects. Physical activity enhances function reduces markers, promoting stability. Tobacco smoke pollution are linked increased instability. Psychosocial stressors, variations, lower status similarly progression through diverse mechanisms. Conclusion: underscores multifaceted impact diet, pathogenesis. Understanding is critical developing comprehensive strategies risk improve cardiovascular outcomes globally. Integrated public initiatives targeted policy interventions addressing essential prevention management.

Language: Английский

Citations

0
Unveiling the Interaction and Combined Effects of Multiple Metals/Metalloids Exposure to TNF-α and Kidney Function in Adults using Bayesian Kernel Machine Regression and Quantile-based G-computation DOI

Kuei‐Hau Luo,

Hung‐Pin Tu,

Yong-Chuan Chung

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127552 - 127552

Published: Oct. 19, 2024

Language: Английский

Citations

0
Association between oxidative balance score and serum cobalt level in population with metal implants: a cross-sectional study from NHANES 2015–2020 DOI Creative Commons

Wenxiu Yuan,

Jing Chen, Jun Sun

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 6, 2024

Background Growing evidence indicates that metal implants influence the body’s oxidative stress status, which in turn affects degradation and stability of implants. The balance score (OBS) is a composite indicator, reflecting overall pro-and antioxidants human body. However, associations between OBS level ions on population with remain to be elucidated. Methods We conducted cross-sectional study using data from 2015 2020 National Health Nutrition Examination Survey (NHANES). Dietary lifestyle factors closely associated were quantified calculate OBS. Weighted multivariate logistic regression smooth curve fittings performed examine relationship serum cobalt levels. Subgroup analyses stratified by age gender. In cases where non-linearity was detected, threshold effects assessed two-piecewise linear model. Results A total 549 participants included this analysis. dietary negatively fully adjusted model ( β = −0.179, 95%CI: −0.358 −0.001, P : 0.04918). Stratified gender, negative correlation observed only men over 70 years participants. Threshold effect analysis showed relationships OBS, males. There non-linear participants, inflection points identified at 16.3 8.7 for respectively. Conclusion Our confirms inverse individuals implants, highlighting significance optimizing mitigate risk ion toxicity. These findings emphasize importance maintaining an antioxidant diet lifestyle, particularly as they offer greater protective males elderly population.

Language: Английский

Citations

0