Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 157 - 183
Published: Jan. 1, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 23, 2024
Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed mechanisms its formation continue to explore effective inhibitors in disease. Recent studies shown correlation between pathological neurodegenerative diseases, as well diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for treatment ferroptosis-mediated diseases. This article specifically describes metabolic pathways summarizes reported action natural synthetic small molecule their efficacy The paper also treatments such gene therapy, nanotechnology, summarises challenges encountered clinical translation inhibitors. Finally, relationship other modes discussed, hopefully paving way future drug design discovery.
Language: Английский
Citations
17
Ageing and Neurodegenerative Diseases, Journal Year: 2025, Volume and Issue: 5(1)
Published: Jan. 26, 2025
With aging, neural stem cells (NSCs) undergo age-related changes, including metabolic abnormalities, disrupted protein homeostasis, mitochondrial dysfunction, reduced genetic stability, and more notably, a diminished capacity for proliferation differentiation. These changes may contribute to the development of neurodegenerative diseases such as Alzheimer’s disease (AD) Parkinson’s (PD). In these conditions, disease-specific pathological interact with alterations NSCs, resulting in impairment neurogenesis, which further leads cognitive, mood, motor decline. Based on potential therapeutics targeting neurogenesis cell-based therapies restore functions NSCs replace degenerated neurons, aiming ameliorate functional decline diseases. While therapies, cell transplantation secretome therapy, show great treatment diseases, challenges tumorigenesis, immune rejection, extraction or storage need be addressed. A better understanding age- disease-related underlying mechanism driving benefits drawbacks therapeutic approaches provide insights novel disease-modifying interventions future
Language: Английский
Citations
0
Methods in molecular biology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
International Ophthalmology, Journal Year: 2025, Volume and Issue: 45(1)
Published: March 22, 2025
Language: Английский
Citations
0
Cellular and Molecular Life Sciences, Journal Year: 2025, Volume and Issue: 82(1)
Published: April 7, 2025
Neurodegeneration is one of the leading factor for death globally, affecting millions people. Developing animal models are critical to understand biological processes and comprehend pathological hallmarks neurodegenerative diseases. For decades, many have served as excellent tools determine disease progression, develop diagnostic methods design novel therapies against distinct pathologies. Here, we provide a comprehensive overview both, mammalian non-mammalian models, with focus on three most common aggressive disorders: Alzheimer's disease, Parkinson's Spinocerebellar ataxia-1. We highlight various approaches including transgene, gene transfer, chemically-induced used models. In particular, discuss applications both contributions in research neurodegeneration. It exciting learn roles pathomechanisms, identifying biomarkers hence devising interventions treat neuropathological conditions.
Language: Английский
Citations
0
ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Language: Английский
Citations
0
Translational Oncology, Journal Year: 2025, Volume and Issue: 56, P. 102391 - 102391
Published: April 14, 2025
Language: Английский
Citations
0
World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(10), P. 860 - 872
Published: Oct. 24, 2024
The burgeoning field of bioengineering has witnessed significant strides due to the advent stem cell models, particularly in their application advanced therapy medicinal products (ATMPs). In this review, we examine multifaceted impact these developments, emphasizing potential models enhance sophistication ATMPs and offer alternatives animal testing. Stem cell-derived tissues are promising because they can reshape preclinical landscape by providing more physiologically relevant ethically sound platforms for drug screening disease modelling. We also discuss critical challenges reproducibility accuracy measurements ensure integrity utility research application. Moreover, review highlights imperative align with regulatory standards, ensuring using cells translates into safe effective clinical therapies. With approval serving as a gateway adoption, collaborative efforts between scientists regulators vital progression applications from bench bedside. advocate balanced approach that nurtures innovation within framework rigorous validation compliance, cell-base solutions maximized promote public trust patient health ATMPs.
Language: Английский
Citations
3
Animal Models and Experimental Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 7, 2024
Abstract Animal models have been a crucial tool in neuroscience research for decades, providing insights into the biomedical and evolutionary mechanisms of nervous system, disease, behavior. However, their use has raised concerns on several ethical, clinical, scientific considerations. The welfare animals 3R principles (replacement, reduction, refinement) are focus ethical concerns, targeting importance reducing stress suffering these models. Several laws guidelines applied developed to protect animal rights during experimenting. Concurrently, clinic fields, discussions relevance model findings human organisms increased. Latest data suggest that considerable amount time results not translatable humans, costing money. Alternative methods, such as vitro (cell culture, microscopy, organoids, micro physiological systems) techniques silico (computational) modeling, emerged potential replacements models, more accurate minimized cost. By adopting alternative methods promoting considerations practices, we can achieve goals while upholding our responsibility both humans other animals. Our goal is present thorough review used from biomedical, evolutionary, perspectives. novelty this lies integrating diverse points views provide an understanding advantages disadvantages discussing methods.
Language: Английский
Citations
2
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(35), P. 45861 - 45870
Published: Aug. 23, 2024
In vitro cardiomyocyte mechano-sensing platform is crucial for evaluating the mechanical performance of cardiac tissues and will be an indispensable tool application in drug discovery disease mechanism study. Magnetic sensing offers significant advantages real-time, situ wireless monitoring resistance to ion interference. However, due mismatch between stiffness traditional rigid magnetic material myocardial tissue, sensitivity insufficient it difficult achieve cell structure induction three-dimensional cultivation. Herein, a that integrates neodymium–iron–boron/polydimethylsiloxane (NdFeB/PDMS) flexible microbeam with suspended ordered polycaprolactone (PCL) nanofiber membranes was developed, providing anisotropic culture environment growth simultaneously realizing contractility monitoring. The as-prepared sensor presented ultrahigh 442.2 μV/μm deflection resolution 2 μm. By continuously status stimulation feedback, we verified capability capture dynamic changes contractility. This provides perspective maturity performance.
Language: Английский
Citations
1