Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children

JAMA Network Open, Journal Year: 2021, Volume and Issue: 4(6), P. e2111182 - e2111182

Published: June 7, 2021

Importance

Information on underlying conditions and severe COVID-19 illness among children is limited.

Objective

To examine the risk of associated with medical complexity.

Design, Setting, Participants

This cross-sectional study included patients aged 18 years younger withInternational Statistical Classification Diseases, Tenth Revision, Clinical Modification code U07.1 (COVID-19) or B97.29 (other coronavirus) during an emergency department inpatient encounter from March 2020 through January 2021. Data were collected Premier Healthcare Database Special Release, which data more than 800 US hospitals. Multivariable generalized linear models, controlling for patient hospital characteristics, used to estimate adjusted

Exposures

Underlying complexity (ie, presence complex noncomplex chronic disease).

Main Outcomes Measures

Hospitalization when hospitalized combined outcome intensive care unit admission, invasive mechanical ventilation, death).

Results

Among 43 465 younger, median (interquartile range) age was 12 (4-16) years, 22 943 (52.8%) female patients, 491 (28.7%) had conditions. The most common diagnosed asthma (4416 [10.2%]), neurodevelopmental disorders (1690 [3.9%]), anxiety fear-related (1374 [3.2%]), depressive (1209 [2.8%]), obesity (1071 [2.5%]). strongest factors hospitalization type 1 diabetes (adjusted ratio [aRR], 4.60; 95% CI, 3.91-5.42) (aRR, 3.07; 2.66-3.54), 2.38; 2.06-2.76) cardiac circulatory congenital anomalies 1.72; 1.48-1.99). Prematurity a factor 2 1.83; 1.47-2.29). Chronic disease hospitalization, aRRs 2.91 (95% 2.63-3.23) 7.86 6.91-8.95), respectively, as well illness, 1.95 1.69-2.26) 2.86 2.47-3.32), respectively.

Conclusions Relevance

found higher certain conditions, such diabetes, anomalies, obesity. Health practitioners could consider potential need close observation cautious clinical management these COVID-19.

Language: Английский

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Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2020, Volume and Issue: 106(3), P. e1343 - e1353

Published: Oct. 27, 2020

The role of vitamin D status in COVID-19 patients is a matter debate.To assess serum 25-hydroxyvitamin (25OHD) levels hospitalized with and to analyze the possible influence on disease severity.Retrospective case-control study 216 197 population-based controls. Serum 25OHD were measured both groups. association severity (admission intensive care unit, requirements for mechanical ventilation, or mortality) was also evaluated.Of patients, 19 supplements analyzed separately. In mean ± standard deviation 13.8 7.2 ng/mL, compared 20.9 7.4 ng/mL controls (P < .0001). values lower men than women. Vitamin deficiency found 82.2% cases 47.2% inversely correlates ferritin = .013) D-dimer .027). D-deficient had greater prevalence hypertension cardiovascular diseases, raised troponin levels, as well longer length hospital stay those ≥20 ng/mL. No causal relationship between combined endpoint its separate components.25OHD are these higher deficiency. We did not find any concentrations disease.

Language: Английский

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Endocrine and metabolic aspects of the COVID-19 pandemic

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2020, Volume and Issue: 21(4), P. 495 - 507

Published: July 9, 2020

COVID-19 infection has tremendously impacted our daily clinical practice as well social living organization. Virtually all organs and biological systems suffer from this new coronavirus infection, either because the virus targets directly specific tissues or of indirect effects. Endocrine diseases are not an exception some endocrine at risk direct lesion by COVID-19. Although there is still no evidence higher predisposition to contract in patients with diabetes and/or obesity, coexistence these conditions contributes a worse prognosis both confer impaired immunologic system. Cytokines storm can be amplified two latter thereby leading multisystemic failure death. Glycaemic control been demonstrated crucial avoiding long hospital stays, ICU requirement also prevention excessive mortality. treatment modifications consequence required proactive manner, order avoid decompensation eventual admission. This case adrenal insufficiency which prompt increase insulin dosage substitutive steroids through adoption sick day's rules should warranted, easy contact health care provider telematic different modalities. New possible endocrinological have recently described warrant full study next future.

Language: Английский

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The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis

Metabolism, Journal Year: 2021, Volume and Issue: 119, P. 154753 - 154753

Published: March 24, 2021

Disease severity and mortality rates due to COVID-19 infection are greater in the elderly chronically ill patients, populations at high risk for vitamin D deficiency. Vitamin plays an important role immune function inflammation. This systematic review meta-analysis assesses impact of status supplementation on related health outcomes.

Language: Английский

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Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2021, Volume and Issue: 22(4), P. 1201 - 1218

Published: Dec. 1, 2021

The 4

Language: Английский

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Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy

European Journal of Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 232, P. 114175 - 114175

Published: Feb. 4, 2022

Language: Английский

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Low Vitamin D Levels Are Associated With Long COVID Syndrome in COVID-19 Survivors

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 108(10), P. e1106 - e1116

Published: April 13, 2023

Long COVID is an emerging syndrome affecting 50% to 70% of COVID-19 survivors that still lacks predicting factors.Due the extraskeletal effects vitamin D, we retrospectively assessed association between 25(OH) D levels and long in 6 months after hospitalization.Long was defined according NICE guidelines. Fifty 50 non-long-COVID subjects matched on a 1:1 basis were enrolled from outpatient clinic post-COVID cohort seen August November 2020. Therapies/comorbidities calcium/vitamin D/bone metabolism, and/or admission intensive care unit during hospitalization exclusion criteria. Vitamin measured at hospital discharge.We observed lower levels, evaluated follow-up, with than those without (20.1 vs 23.2 ng/mL, P = .03). Regarding affected health areas entire cohort, neurocognitive symptoms follow-up (n 7) 93) (14.6 20.6 .042). In patients presenting deficiency (<20 ng/mL), both 42), by 22) presented not 20) (12.7 15.2 .041). multiple regression analyses, only variable significantly associated our (P .008, OR 1.09, CI 1.01-1.16).COVID-19 have COVID. Our data suggest should be discharge. The role supplementation as preventive strategy sequelae tested randomized controlled trials.

Language: Английский

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COVID-19 and Bone Loss: A Review of Risk Factors, Mechanisms, and Future Directions

Current Osteoporosis Reports, Journal Year: 2024, Volume and Issue: 22(1), P. 122 - 134

Published: Jan. 15, 2024

Abstract Purpose of Review SARS-CoV-2 drove the catastrophic global phenomenon COVID-19 pandemic resulting in a multitude systemic health issues, including bone loss. The purpose this review is to summarize recent findings related loss and potential mechanisms. Recent Findings early clinical evidence indicates an increase vertebral fractures, hypocalcemia, vitamin D deficiencies, BMD among patients. Additionally, lower associated with more severe infection. Preclinical models have shown increased osteoclastogenesis. infection could be result many factors that directly affect such as higher inflammation, activation NLRP3 inflammasome, recruitment Th17 cells, hypoxic environment, changes RANKL/OPG signaling. can exert indirect effects on skeleton, mechanical unloading may occur disease (e.g., bed rest) or BMI muscle wasting has also been Muscle cause issues influence bone. Medications used treat negative effect Lastly, worsen conditions diabetes negatively kidney function, all which contribute fracture risk. Summary through multiple direct Future work will needed determine what patient populations are at risk COVID-19-related increases risk, mechanisms behind loss, therapeutic options. This article part series manuscripts designed utility using artificial intelligence for writing scientific reviews.

Language: Английский

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SARS-CoV-2 and its Multifaceted Impact on Bone Health: Mechanisms and Clinical Evidence

Current Osteoporosis Reports, Journal Year: 2024, Volume and Issue: 22(1), P. 135 - 145

Published: Jan. 18, 2024

SARS-CoV-2 infection, the culprit of COVID-19 pandemic, has been associated with significant long-term effects on various organ systems, including bone health. This review explores current understanding impacts infection health and its potential consequences.

Language: Английский

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COVID-19 and endocrine and metabolic diseases. An updated statement from the European Society of Endocrinology

Endocrine, Journal Year: 2021, Volume and Issue: 72(2), P. 301 - 316

Published: May 1, 2021

COVID-19 has completely changed our daily clinical practice as well social relations. Many organs and biological systems are involved in SARS-Cov-2 infection, either due to direct virus-induced damage or indirect effects that can have systemic consequences. Endocrine system is not only an exception but its involvement so relevant "endocrine phenotype" of progressively acquired relevance.

Language: Английский

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