Therapeutic role of vitamin D in COVID-19 patients DOI Creative Commons

Muhammad Imran,

Ramna Zia,

Maryam Ali

et al.

Clinical Nutrition Open Science, Journal Year: 2024, Volume and Issue: 57, P. 78 - 87

Published: July 16, 2024

SARS-CoV-2 has had a significant worldwide impact, leading to widespread illness and mortality. With the lack of specific antiviral treatments, there is growing interest in exploring potential therapeutic effects various nutritional supplements, including vitamin D. Vitamin D plays an essential role health, been implicated modulating immune response reducing inflammation, which may have implications prevention management coronavirus disease 2019 (COVID-19). Patients having low level are predisposed severe consequences. COVID-19 shown inverse relationship. This review understanding remedial COVID-19, its mechanism action, evidence from clinical studies, recommendations for supplementation patients suffering COVID-19.Material MethodsGoogle scholar, Sci-Hub, pubmed.

Language: Английский

A view on vitamin D: a pleiotropic factor? DOI
Andrea Giustina, Marise Lazaretti‐Castro, Adrian R. Martineau

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(4), P. 202 - 208

Published: Jan. 22, 2024

Language: Английский

Citations

16
Pilot study to define criteria for Pituitary Tumors Centers of Excellence (PTCOE): results of an audit of leading international centers DOI Creative Commons
Andrea Giustina, Meliha Melin Uygur, Stefano Frara

et al.

Pituitary, Journal Year: 2023, Volume and Issue: 26(5), P. 583 - 596

Published: Aug. 28, 2023

The Pituitary Society established the concept and mostly qualitative parameters for defining uniform criteria Tumor Centers of Excellence (PTCOEs) based on expert consensus. Aim study was to validate those previously proposed through collection evaluation self-reported activity several internationally-recognized tertiary pituitary centers, thereby transforming 2017 definition into a validated quantitative one, which could serve as basis future objective PTCOE accreditation.An ad hoc prepared database distributed nine chosen by Project Scientific Committee comprising worldwide repute, agreed provide information derived from registries related years 2018-2020 completing within 60 days. database, provided each center composed Excel® spreadsheets with requested specific leading supporting teams, reviewed two blinded referees all 9 candidate centers satisfied overall definition, according referees' evaluations. To obtain numerical criteria, median values activity/parameter were considered preferred target, whereas low limit range selected acceptable target respective parameter.Three dedicated neurosurgeons are preferred, one surgeon is acceptable. Moreover, 100 surgical procedures per year while results indicated that 50 surgeries Acute post-surgery complications, including mortality readmission rates, should preferably be negligible or nonexistent, but criterion rate lower than 10% patients complications requiring 30 days after surgery. Four endocrinologists devoted diseases in total population followed not less 850. It appears at least dedicated/expert present neuroradiology, pathology, ophthalmology groups, radiation oncologists needed.This is, our knowledge, first survey evaluate relevant number high-volume field. This effort, internally reviewers, allowed transformation formulated theoretical precise definitions real-life evidence. application synopsis used independent bodies accreditation PTCOEs.

Language: Английский

Citations

35
Long COVID and pituitary dysfunctions: a bidirectional relationship? DOI
Luigi di Filippo,

Vincenzo Franzese,

Simona Santoro

et al.

Pituitary, Journal Year: 2024, Volume and Issue: 27(6), P. 955 - 969

Published: Sept. 6, 2024

Language: Английский

Citations

7
New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases DOI
Luigi di Filippo, John P. Bilezikian, Ernesto Canalis

et al.

Endocrine, Journal Year: 2024, Volume and Issue: 85(3), P. 1007 - 1019

Published: April 17, 2024

Language: Английский

Citations

5
Morphometric vertebral fractures at hospitalization associate with Long COVID occurrence DOI
Luigi di Filippo,

Mauro Doga,

Francesca Mangini

et al.

Journal of Endocrinological Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

Citations

0
Impact of vitamin D levels on mortality in older covid-19 vaccinated patients DOI Creative Commons
Chiara Ceolin, Margherita Vergadoro,

Cristina Simonato

et al.

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 10, 2025

Abstract Background Vitamin D plays a key role in regulating the immune system and vaccine response, hypovitaminosis is known risk factor for mortality. However, its potential influence on mortality SARS-CoV-2 vaccinated older adults remains underexplored. This study aims to examine survival differences between unvaccinated with varying vitamin levels, assess impact of Methods We recruited patients aged 65 over from Geriatrics Unit Azienda Ospedale - Università Padova. Clinical, pharmacological data, including vaccination status were collected at admission, alongside data 12 months post-hospitalization. Participants divided into three groups: unvaccinated, levels 25–50 nmol/L, > 50 nmol/L. Results A total 126 participants included (56% women, mean age 83 years). No significant found COVID-19 severity among groups. After months, 24 deaths recorded: 17% 19% low D, 20% high ( p = 0.94). Kaplan-Meier curves showed that individuals was similar but significantly higher than 0.04). nmol/L associated threefold increased 12-month (HR: 3.79, < 0.001). Conclusions can individuals. Early correction deficiency could potentially enhance outcomes.

Language: Английский

Citations

0
Vitamin D: A Nutraceutical Supplement at the Crossroad Between Respiratory Infections and COVID-19 DOI Open Access
Manuela Rizzi, Pier Paolo Sainaghi

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2550 - 2550

Published: March 12, 2025

Even though in mid-2023 the World Health Organization declared end of public health emergency international concern status for COVID-19, many areas uncertainty about SARS-CoV-2 infection pathophysiology remain. Although last 4 years pharmaceutical industries widely invested development effective antiviral treatments and vaccines, large disparities their availability worldwide still exist, thus fostering investigation nutritional supplements as adjuvant therapeutic approaches disease management, especially resource-limited settings. During COVID-19 pandemic, vitamin D has been used an over-the-counter solution to improve evolution, thanks its known immunomodulatory anti-inflammatory actions. Ecological observational studies support a relationship between hypovitaminosis negative outcomes and, according this evidence, several research groups investigated role supplementation protecting from and/or improving evolution. This narrative review is intended offer insights into existing data on D’s biological effects respiratory infections, COVID-19. Furthermore, it will also brief overview complex interplay vaccine-elicited immune response, with special attention anti-COVID-19 vaccines.

Language: Английский

Citations

0
Novel protective circulating miRNA are associated with preserved vitamin D levels in patients with mild COVID-19 presentation at hospital admission not progressing into severe disease DOI Creative Commons
Luigi di Filippo,

Umberto Terenzi,

Giovanni Di Ienno

et al.

Endocrine, Journal Year: 2024, Volume and Issue: 86(1), P. 119 - 123

Published: June 10, 2024

Low vitamin D levels were reported to negatively influence the outcomes of acute COVID-19, as well other biochemical markers linked including microRNAs (miRNAs). This study aimed prospectively evaluate miRNAs and relationship in predicting COVID-19 outcomes.

Language: Английский

Citations

2
Changes in vitamin D status among adults from the COVID-19 pandemic to post-pandemic normality DOI Creative Commons
Yanzhao Chen,

Guilian Kong

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 2, 2024

The COVID-19 pandemic has prompted widespread lockdown measures globally, significantly impacting daily activities and outdoor exposure. This study investigates the effect of on vitamin D levels prevalence deficiency in adult population, with a focus gender-specific differences.

Language: Английский

Citations

2
Impact of vitamin D deficiency in relation to the clinical outcomes of hospitalized COVID-19 patients DOI Creative Commons
Andhika Rachman,

Rizky Rahmaniyah,

Andi Khomeini

et al.

F1000Research, Journal Year: 2023, Volume and Issue: 12, P. 394 - 394

Published: Sept. 11, 2023

Background: Vitamin D deficiency is an emerging public health problem that affects more than one billion people worldwide. has been shown to be effective in preventing and reducing the severity of viral respiratory diseases, including influenza. However, role vitamin COVID-19 infection remains controversial. This study aimed analyze impact on clinical outcome hospitalized patients. Methods: A prospective cohort was conducted among patients at two referral hospitals Indonesia from October 2021 until February 2022. Results: The median serum 25(OH)D level 191 13.6 [IQR=10.98] ng/mL. levels were significantly lower with who had cardiovascular disease (p-value=0.04), use a ventilator (p-value=0.004), severe cases (p-value=0.047), mortality (p-value=0.002). Furthermore, different between mild (p-value <0.001). Serum moderate Lower associated increased number comorbidities (p-value=0.03), (p-value=0.002), mechanical ventilation (p-value=0.032). Mortality found 7.3% deficient levels. either sufficient or insufficient did not develop mortality. Conclusions: having disease, mortality, cases, used ventilation. comorbidities, severity, mechanical-ventilation. Thus, we suggest reach status improve disease.

Language: Английский

Citations

6