Current Overview of Metal Nanoparticles’ Synthesis, Characterization, and Biomedical Applications, with a Focus on Silver and Gold Nanoparticles

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(10), P. 1410 - 1410

Published: Oct. 4, 2023

Metal nanoparticles (NPs) have garnered considerable attention, due to their unique physicochemical properties, that render them promising candidates for various applications in medicine and industry. This article offers a comprehensive overview of the most recent advancements manufacturing, characterization, biomedical utilization metal NPs, with primary focus on silver gold NPs. Their potential as effective anticancer, anti-inflammatory, antimicrobial agents, drug delivery systems, imaging agents diagnosis treatment variety disorders is reviewed. Moreover, translation therapeutic settings, issue inclusion clinical trials, are assessed light over 30 investigations concentrate administering either or NPs conditions ranging from nosocomial infections different types cancers. paper aims not only examine biocompatibility nanomaterials but also emphasize challenges may limit safe integration into healthcare practices. More than 100 nanomedicines currently market, which justifies ongoing study use medicine. Overall, present review highlight innovative therapeutics field biomedicine, citing some relevant current applications.

Language: Английский

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Review of Advances in Coating and Functionalization of Gold Nanoparticles: From Theory to Biomedical Application

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 255 - 255

Published: Feb. 9, 2024

Nanoparticles, especially gold nanoparticles (Au NPs) have gained increasing interest in biomedical applications. Used for disease prevention, diagnosis and therapies, its significant advantages therapeutic efficacy safety been the main target of interest. Its application immune system stability physiological environments cell membranes, low toxicity optimal bioperformances are critical to success engineered nanomaterials. unique optical properties great attractors. Recently, several physical chemical methods coating these NPs widely used. Biomolecules such as DNA, RNA, peptides, antibodies, proteins, carbohydrates biopolymers, among others, used coatings Au various applications, thus their biocompatibility while maintaining biological functions. This review mainly presents a general representative view different types NP functionalization using biomolecules, strategies mechanisms.

Language: Английский

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Apigenin-coated gold nanoparticles as a cardioprotective strategy against doxorubicin-induced cardiotoxicity in male rats via reducing apoptosis

Heliyon, Journal Year: 2023, Volume and Issue: 9(3), P. e14024 - e14024

Published: Feb. 25, 2023

Cardiotoxicity is associated with doxorubicin (DOX), an effective anticancer drug. Apigenin has cardioprotective properties; it may be employed as a capping and reducing agent in synthesizing gold nanoparticles (AuNPs). This study examined the impact of AuNPs synthesized apigenin (Api) DOX-induced cardiotoxicity (DIC).Api-AuNPs were single pot without needing additional reagents for ions or stabilizing NPs. The cytotoxicity Api-AuNPs on H9c2 heart cells was subsequently determined using MTT assay. In animal investigation, 40 male rats randomly assigned to one four groups: control, DOX treated (DOX + Api), Api-AuNPs). To examine function, echocardiography conducted. Blood samples obtained evaluate injury indicators (Lactate dehydrogenase (LDH), creatine kinase MB (CK-MB), Cardiac Troponin I (cTn-I), Alanine transaminase (ALT), Aspartate (AST)). removed under general anesthetic, weighed, preserved formalin solution. Six micrometer-thick cardiac tissue sections stained hematoxylin, eosin (H&E), immunohistochemistry identify cardiomyocyte apoptotic markers (Bax, Bcl-2, caspase3).Api-AuNPs have average size 21.4 ± 11.6 nm are stable physiological environments. therapy substantially reduced body weight loss compared group. Injury dramatically by treatment. inhibited myocardial apoptosis via modulating Bax, caspase3, Bcl-2 ameliorating damage caused DOX.Api-AuNPs' anti-apoptotic activities provide cardioprotection against DIC. It potential reduce boost performance.

Language: Английский

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Gold cluster encapsulated liposomes: theranostic agent with stimulus triggered release capability

Medical Oncology, Journal Year: 2023, Volume and Issue: 40(5)

Published: March 24, 2023

Language: Английский

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Therapeutic potential of lactoferrin-coated iron oxide nanospheres for targeted hyperthermia in gastric cancer

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Oct. 19, 2023

Lactoferrin (LF) is a non-heme iron-binding glycoprotein involved in the transport of iron blood plasma. In addition, it has many biological functions, including antibacterial, antiviral, antimicrobial, antiparasitic, and, importantly, antitumor properties. this study, we have investigated potential employing lactoferrin-iron oxide nanoparticles (LF-IONPs) as treatment modality for gastric cancer. The study confirms formation LF-IONPs with spherical shape and an average size 5 ± 2 nm, embedded within protein matrix. FTIR Raman analysis revealed that Fe-O bond stabilized particle interactions. Further, conducted hyperthermia studies to ascertain whether proposed composite can generate sufficient rise temperature at low frequency. results confirmed achieve about 7 °C 242.4 kHz, which be further harnessed cancer treatment. particles were tested their anti-cancer activity on AGS cells, without hyperthermia. Results indicate (10 µg/ml) significantly enhance cytotoxicity, resulting demise 67.75 5.2% cells post hyperthermia, while also exhibiting inhibitory effect cell migration compared control most inhibition observed after 36 h These findings suggest targeted

Language: Английский

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Pharmacological impact of microRNAs in head and neck squamous cell carcinoma: Prevailing insights on molecular pathways, diagnosis, and nanomedicine treatment

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: May 3, 2023

Head and neck squamous cell carcinoma is a disease that most commonly produce tumours from the lining of epithelial cells lips, larynx, nasopharynx, mouth, or oro-pharynx. It one deadly forms cancer. About to two percent all neo-plasm-related deaths are attributed head carcinoma, which responsible for about six cancers. MicroRNAs play critical role in proliferation, differentiation, tumorigenesis, stress response, triggering apoptosis, other physiological process. regulate gene expression provide new diagnostic, prognostic, therapeutic options carcinoma. In this work, molecular signaling pathways related emphasized. We also an overview MicroRNA downregulation overexpression its as diagnostic prognostic marker recent years, nano-based therapies have been explored. addition, nanotechnology-based alternatives discussed promising strategy exploring paradigms aimed at improving efficacy conventional cytotoxic chemotherapeutic agents against attenuating their cytotoxicity. This article provides information on ongoing recently completed clinical trials based nanotechnology.

Language: Английский

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Fungal endophytes: Treasure trove for green synthesis of metallic nanoparticles and their biological applications

Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: 60, P. 103307 - 103307

Published: June 24, 2024

Language: Английский

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Anti-Proliferative Activity of Poloxamer Cobalt Ferrite Nanoparticles against Human Prostate Cancer (DU-145) Cells: In-Vitro Study

IET Nanobiotechnology, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 8

Published: March 20, 2024

Prostate cancer is the second most frequent type of death in men. This study refers to novel hyperthermia application poloxamer-coated cobalt ferrite as a new approach for thermal eradication DU-145 human prostate cancerous cells under radio frequency magnetic field (RF-MF). The hydrothermal method was applied synthesis nanoparticles. Then, structure, size, and morphology nanoparticle were characterized. cytotoxicity synthesized nanoparticles RF-MF exposure on investigated separately or combination with colony formation methods MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] assay. Transmission electron microscopy (TEM) confirmed spherical size 5.5 ± 2.6 nm. temperature treated reached 42.73 0.2°C after 15 min. treatment have not affected cell viability significantly. However, them eradicated 53% 4% cells. In-vitro performed (DU-145) at specific concentrations that demonstrated decrease survival fraction based assay compared alone RF-MF.

Language: Английский

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Multifunctional plant virus nanoparticles: An emerging strategy for therapy of cancer

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2022, Volume and Issue: 15(6)

Published: Nov. 30, 2022

Abstract Cancer therapy requires sophisticated treatment strategies to obtain the highest success. Nanotechnology is enabling, revolutionizing, and multidisciplinary concepts improve conventional cancer modalities. Nanomaterials have a central role in this scenario, explaining why various nanomaterials are currently being developed for therapy. Viral nanoparticles (VNPs) shown promising performance due their unique features. VNPs possess morphological homogeneity, ease of functionalization, biocompatibility, biodegradability, water solubility, high absorption efficiency that beneficial applications. In current review paper, we highlight state‐of‐the‐art properties potentials plant viruses, multifunctional formulations, potential applications challenges VNPs‐based therapy, finally practical solutions bring one step closer real This article categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease Biology Nanoscale Systems Biology‐Inspired Protein Virus‐Based Structures

Language: Английский

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Green synthesized apigenin conjugated gold nanoparticles inhibit cholangiocarcinoma cell activity and endothelial cell angiogenesis in vitro

Heliyon, Journal Year: 2022, Volume and Issue: 8(12), P. e12028 - e12028

Published: Dec. 1, 2022

Cholangiocarcinoma (CCA) is a rare malignancy of the biliary tract with extremely poor clinical outcomes due to lack effective therapies improve disease management. The emerging green synthesis gold nanoparticles (AuNPs) has extensively provided their use in biomedical applications. In this study, we developed AuNPs via reducing salts apigenin (4',5,7-trihydroxyflavone). synthesized apigenin-conjugated (api-AuNPs) were physicochemically characterized by various techniques before evaluation biological and functional inhibition CCA cell line, KKU-M055. mean size api-AuNPs was 90.34 ± 22.82 nm zeta potential -36 0.55. half-maximal inhibitory concentration (IC

Language: Английский

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