Experimental Cell Research, Journal Year: 2024, Volume and Issue: 442(2), P. 114278 - 114278
Published: Oct. 1, 2024
Language: Английский
The Journal of Liquid Biopsy, Journal Year: 2024, Volume and Issue: 3, P. 100139 - 100139
Published: Jan. 5, 2024
Recent advances in cancer treatment emphasize the pivotal role of extracellular vesicles (EVs), especially exosomes (a subpopulation EVs, originating from endosomes). Exosomes are signaling molecules cellular system. Its molecular signature displays status cell (cell healthy or undergoing any clinical complication). frontiers upcoming theranostics era. This article highlighted exosome complex interlink, advantage exosome-base liquid biopsy, effectiveness exosome-based cell-free therapy compared to therapy, complications research, and its solution. Hope, this motivated researchers explore precision oncology
Language: Английский
Citations
6
Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(8), P. 104061 - 104061
Published: June 18, 2024
Language: Английский
Citations
6
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(3), P. 1400 - 1415
Published: Feb. 23, 2024
Exosomes are a subpopulation of extracellular vesicles (EVs) secreted by cells. In cancer, they key cellular messengers during cancer development and progression. Tumor-derived exosomes (TEXs) promote oral the major complication is squamous cell carcinoma (OSCC). show strong participation in several OSCC-related activities such as uncontrolled growth, immune suppression, angiogenesis, metastasis, drug therapeutic resistance. It also potential biomarker source for cancer. Some exosome sources stem cells, plants (it more effective compared to others), engineered reduce development. This approach because its specificity, biocompatibility, cell-free therapy reduced side effects treatment). article highlights exosome-based theranostics signatures clinical trials, challenges research, future improvements. future, may become an affordable solution
Language: Английский
Citations
5
Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(4)
Published: April 1, 2024
Abstract Exosomes play a crucial role in intercellular communication and have emerged as significant vehicles for transporting disease‐specific biomarkers. This feature provides profound insights into the progression of diseases responses patients to treatments. For example, leukemia, exosomes convey critical information through carriage specific proteins nucleic acids. In case human papillomavirus (HPV)‐mediated cervical cancer, are particularly useful noninvasive detection they transport high‐risk HPV DNA biomolecules, which can be indicators disease. Despite their vast potential, there several challenges associated with use medical diagnostics. These include inherent heterogeneity, need enhanced sensitivity methods, establishment standardization protocols, requirement cost‐effective scalability application. Addressing these is effective implementation exosome‐based Future research development geared towards overcoming obstacles. Efforts concentrated on refining processes biomarker discovery, establishing comprehensive regulatory frameworks, developing convenient point‐of‐care devices, exploring methods multimodal detection, conducting extensive clinical trials. The ultimate goal efforts inaugurate new era precision diagnostics within healthcare. would significantly improve patient outcomes reduce burden such leukemia HPV‐mediated cancer. integration cutting‐edge technology holds promise reinforcing foundations healthcare, leading diagnostic accuracy, better disease monitoring, more personalized therapeutic approaches.
Language: Английский
Citations
5
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 7076 - 7087
Published: Nov. 4, 2024
Extracellular vesicles (EVs) are cellular communication molecules and classified into three major subpopulations, such as microvesicles, apoptotic bodies, exosomes. Among these, exosomes-based cancer research is a cutting-edge investigation approach to understanding. During progression , tumor-derived exosomes can reprogram the system promote cancer. Circulating in body fluids blood, plasma, serum, saliva, CSF, sweat, tears play key role identifying diagnostic prognostic biomarkers. Diverse therapeutic sources of including stem cells, plants, immune etc. exhibit significant cancer-healing properties. Although cancer-targeting immunotherapy an effective strategy, it has limitations toxicity, high costs. In comparison, cell-derived cell-free for treatment advantages like less biocompatibility, reduced immunogenicity, efficient, target-specific development. This review highlights signature treatment.
Language: Английский
Citations
4
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: March 13, 2025
Exosomes, nanosized extracellular vesicles released by various cell types, are intensively studied for the diagnosis and treatment of cancer neurodegenerative diseases, they also display high usability in regenerative medicine. Emphasizing their diagnostic potential, exosomes serve as carriers disease-specific biomarkers, enabling non-invasive early detection personalized The cargo loading with therapeutic agents presents an innovative strategy targeted drug delivery, minimizing off-target effects optimizing interventions. In medicine, play a crucial role intercellular communication, facilitating tissue regeneration through transmission bioactive molecules. While acknowledging existing challenges standardization scalability, ongoing research efforts aim to refine methodologies address regulatory considerations. summary, this review underscores transformative potential reshaping landscape medical interventions, particular emphasis on cancer,
Language: Английский
Citations
0
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)
Published: April 21, 2025
Language: Английский
Citations
0
Drug Discovery Today, Journal Year: 2023, Volume and Issue: 28(11), P. 103791 - 103791
Published: Sept. 28, 2023
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3703 - 3703
Published: March 26, 2024
Alzheimer’s disease (AD) is the fifth leading cause of death among adults aged 65 and older, yet onset progression poorly understood. What known that presence amyloid, particularly polymerized Aβ42, defines when people are on AD continuum. Interestingly, as progresses, less Aβ42 detectable in plasma, a phenomenon thought to result from Aβ becoming more aggregated brain Aβ40 being transported plasma via CSF. We propose extracellular vesicles (EVs) play role this transport. EVs found bodily fluids such blood, urine, cerebrospinal fluid carry diverse “cargos” bioactive molecules (e.g., proteins, nucleic acids, lipids, metabolites) dynamically reflect changes cells which they secreted. While have been reported be present EVs, it not whether interaction specific for these peptides thus amyloid-carrying and/or serve brain-specific biomarkers process. To determine if there between we used isothermal titration calorimetry (ITC) discovered bind manner sequence specific, saturable, endothermic. In addition, incubation with overnight yielded larger amounts bound peptide was fibrillar structure. These findings point amyloid–EV interaction, potential transport amyloid pool
Language: Английский
Citations
3
The Journal of Liquid Biopsy, Journal Year: 2024, Volume and Issue: 3, P. 100137 - 100137
Published: Jan. 3, 2024
Cancer is the leading cause of death worldwide. The most complicated fact about this disease early diagnosis. Treatment at advanced stages extremely challenging. We need an cancer detection method. Nanotechnology-based liquid biopsy efficient platform for health crisis. Several modifications to method ushered in a new era biopsy. present article addresses transforming signature nanobiotechnology on techniques (it explores its advantages and limitations).
Language: Английский
Citations
2