The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 25, 2024

Abstract Several studies suggest that oral pathogenic biofilms cause persistent infections. Among these is periodontitis, a prevalent condition brought on by plaque biofilm. It can even result in tooth loss. Furthermore, the accumulation of germs around dental implant may lead to peri-implantitis, which damages surrounding bone and gum tissue. bacterial biofilm contamination causes soft tissue irritation adjacent resorption, severely compromising health. On decontaminated surfaces, however, re-osseointegration cannot be induced standard removal techniques such as mechanical cleaning antiseptic treatment. A family nanoparticles known nanozymes (NZs) comprise highly catalytically active multivalent metal components. The most often employed NZs with antibacterial activity are those have peroxidase (POD) activity, among other types NZs. Since less expensive, more easily produced, stable than natural enzymes, they hold great promise for use various applications, including treating microbial significantly contributed studying success rates periodontal health maintenance periodontics implantology. An extensive analysis research their applications managing conditions, caries, pulp disorders, ulcers, infections mouth. To combat bacteria, this review concentrates imitate enzymes implantology periodontology. With view future, there several ways might used treat disorders antibacterially. Graphical

Language: Английский

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Recent advances in nanomaterial-based biosensor for periodontitis detection

Journal of Biological Engineering, Journal Year: 2024, Volume and Issue: 18(1)

Published: April 18, 2024

Periodontitis, a chronic inflammatory condition caused by bacteria, often causes gradual destruction of the components that support teeth, such as alveolar bone, cementum, periodontal ligament, and gingiva. This ultimately results in teeth becoming loose eventually falling out. Timely identification has crucial role preventing controlling its progression. Clinical measures are used to diagnose periodontitis. However, now, there is hunt for alternative diagnostic monitoring methods due progress technology. Various biomarkers have been assessed using multiple bodily fluids sample sources. Furthermore, conventional categorization factors do not provide significant insights into present disease activity, severity amount tissue damage, future development, responsiveness treatment. In recent times, growing utilization nanoparticle (NP)-based detection strategies create quick efficient assays. Every single one these platforms leverages distinct characteristics NPs identify Plasmonic include metal NPs, quantum dots (QDs), carbon base nanozymes, exceptionally potent light absorbers scatterers. These find application labeling, surface-enhanced spectroscopy, color-changing sensors. Fluorescent function photostable sensitive instruments capable labeling various biological targets. article presents comprehensive summary latest developments effective detect

Language: Английский

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Development of Automated Image Processing for High-Throughput Screening of Potential Anti-Chikungunya Virus Compounds

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(1), P. 385 - 385

Published: Jan. 3, 2025

Chikungunya virus, a member of the Alphavirus genus, continues to present global health challenge due its widespread occurrence and absence specific antiviral therapies. Accurate detection viral infections, such as chikungunya, is critical for research, yet traditional methods are time-consuming prone error. This study presents development validation an automated image processing algorithm designed improve accuracy speed high-throughput screening potential anti-chikungunya virus compounds. Using MvTec Halcon software (Version 22.11), was developed detect classify infected uninfected cells in assays, performance validated against manual counts conducted by virology experts, showing strong correlation with Pearson coefficients 0.9807 cell 0.9886 detection. These values indicate high between performed three demonstrating that algorithm’s closely matches expert evaluations. Following statistical validation, applied screen compounds, effectiveness enhancing throughput drug discovery workflows. technology can be seamlessly integrated into existing virological research pipelines, offering scalable efficient tool accelerate diagnostic workflows vector-borne emerging diseases. By addressing bottlenecks accuracy, it holds promise tackling challenges advancing other infections.

Language: Английский

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Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination: Overview of Current Status and Challenges

Biological Procedures Online, Journal Year: 2024, Volume and Issue: 26(1)

Published: June 26, 2024

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus, and zoonosis, affects large regions of Asia, Southwestern Southeastern Europe, Africa. CCHFV can produce symptoms, including no specific clinical mild to severe or deadly infections. Virus isolation attempts, antigen-capture enzyme-linked immunosorbent assay (ELISA), reverse transcription polymerase chain reaction (RT-PCR) are all possible diagnostic tests for CCHFV. Furthermore, an efficient, quick, cheap technology, biosensors, must be designed developed detect The goal this article offer overview modern laboratory available as well other innovative detection methods such biosensors CCHFV, the benefits limits assays. confirmed cases CCHF managed with symptomatic assistance general supportive care. This study examined various treatment modalities, their respective limitations developments, immunotherapy antivirals. Recent biotechnology advancements availability suitable animal models have accelerated development vaccines by substantial margin. We range potential in research, comprising nucleic acid, viral particles, inactivated, multi-epitope vaccines, present obstacles developments field. Thus, purpose review comprehensive summary endeavors dedicated advancing diagnostic, therapeutic, preventive strategies infection anticipation forthcoming hazards.

Language: Английский

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Nano biosensors: Classification, electrochemistry, nanostructures, and optical properties

Results in Engineering, Journal Year: 2024, Volume and Issue: unknown, P. 103428 - 103428

Published: Nov. 1, 2024

Language: Английский

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Portable Point-of-Care Diagnosis Platforms and Emerging Predictive Biomarkers for Rapid Detection of Severe Dengue Viral Infection

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Dengue virus (DENV) infection is a major global public health problem, particularly in tropical and subtropical regions where Aedes mosquitoes are prevalent. The clinical spectrum of dengue ranges from mild febrile illness to severe conditions such as hemorrhagic fever shock syndrome. Early prediction progress crucial for timely therapeutic medications, which can reduce both morbidity mortality. Traditional diagnostic methods serological tests polymerase chain reactions often time-consuming require sophisticated infrastructure skilled personnel. To overcome these limitations, the development point-of-care (POC) diagnosis platforms novel predictive biomarkers providing rapid, real-time tools that be used low-resource settings at patient's bedside. Predictive enable identification disease risk early stages hospitalization visits. This review offers comprehensive overview portable POC emerging rapid DENV infection. Its provides an its epidemiology, discusses burden DENV, explores with different serotypes, well severity dengue. key focus on latest advancements readout devices diagnosis, including colorimetric assay, electrochemical method, lateral flow strip, microfluidic chip platforms. In addition, article various detection while also highlighting limitations associated protein, nucleic acid, metabolic biomarkers. Finally, we address current challenges, potential future directions

Language: Английский

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The Role of Viral Infections in Acute Kidney Injury and Mesenchymal Stem Cell-Based Therapy

Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

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Molecular and serological evidence of chikungunya virus infection with high case fatality among pediatric population with acute encephalitis syndrome: first report from Eastern Uttar Pradesh, India

European Journal of Clinical Microbiology & Infectious Diseases, Journal Year: 2024, Volume and Issue: 43(6), P. 1205 - 1212

Published: April 1, 2024

Language: Английский

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Biodetect: development of a serious game to train Zika Virus detection using biosensors

OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA, Journal Year: 2024, Volume and Issue: 22(8), P. e6138 - e6138

Published: Aug. 6, 2024

The use and handling of biological laboratory components are activities that require great care attention from professionals, as incorrect any component in this environment can cause numerous harms to health ongoing research. In sense, article proposes the development an educational game aimed at teaching training professionals students who deal with protocols. simulates construction a Biosensor identify Zika virus, collecting material analyzing results. plot unfolds two main phases: forest, where character, Little Scientist, seeks capture laboratory, facing challenges such eliminating contaminating viruses manipulating DNA. Specific missions assigned each phase, ranging mosquitoes washing your hands correctly. incorporates historical elements about emergence virus teach protocols through interaction entertainment.

Language: Английский

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Integrating enzyme-nanoparticles bring new prospects for the diagnosis and treatment of immune dysregulation in periodontitis

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 1, 2024

Enzymes play a significant role in mediating inflammatory and immune responses periodontitis. Effective diagnosis, timely treatment, continuous management of periodontal enzymes are essential to prevent undesirable consequences; however, this remains challenge. Nanoparticles (NPs) have attracted attention biomedicine because their advantageous nanosized effects. NPs conjugated with specific enzyme substrates at responsive sites that triggered by periodontitis biomarkers, leading functional or characteristic changes. In contrast, enzyme-mimetic activities exhibit catalytic activity, effectively destroying pathogenic biofilms modulating the response The unique properties enzyme-targeting enabled development biosensors fluorescent probes capable identifying biomarkers associated Enzyme-responsive both exert therapeutic applications treatment review, we provide comprehensive overview periodontitis, mechanisms enzyme-responsive NPs, recent advancements use for detecting these enzymes, targeting mimicking functions. We also discuss challenges prospects using diagnosis

Language: Английский

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