Neuroscience Letters, Journal Year: 2025, Volume and Issue: 852, P. 138178 - 138178
Published: Feb. 22, 2025
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 154, P. 113621 - 113621
Published: Aug. 29, 2022
Neuroinflammation is a key pathophysiological mechanism implicated in the neurodegenerative condition. One such condition implicating neuroinflammation traumatic brain injury (TBI). Over past decades, various alternative natural compounds, as curcumin, have been investigated novel therapeutic options to mitigate pathways and clinical sequelae involved TBI. As main component of turmeric (Curcuma longa), curcumin has broad range properties due its considerable antioxidative anti-inflammatory actions. This review discusses pleiotropic mechanisms, side effects, curcumin's delivery central nervous system (CNS), immunomodulatory protective effects on Clinical trials, vivo, vitro studies were extracted from different scientific databases, including PubMed, Scopus, Google Scholar, assess or derivatives Findings reveal that exhibited some TBI via modulation cell signaling toll-like receptor-4 (TLR-4), nuclear factor kappa B (NF-κB), Nod-like receptor family proteins (NLRPs). Moreover, upregulates brain-derived Neurotrophic Factor/Tropomyosin kinase (BDNF/TrkB) pathway, phosphatidylinositol-3-kinase/protein (PI3K/AKT), erythroid 2-related 2 (Nrf2), which crucial functions pathophysiological-mediated pathways. Curcumin displays beneficial capacities models, although more experiments are required clarify precise mechanisms function
Language: Английский
Citations
94
Biology, Journal Year: 2023, Volume and Issue: 12(8), P. 1139 - 1139
Published: Aug. 17, 2023
Traumatic brain injury (TBI) is one of the leading causes long-lasting morbidity and mortality worldwide, being a devastating condition related to impairment nervous system after an external traumatic event resulting in transitory or permanent functional disability, with significant burden healthcare system. Harmful events underlying TBI can be classified into two sequential stages, primary secondary, which are both associated breakdown tissue homeostasis due blood–brain barrier, osmotic imbalance, inflammatory processes, oxidative stress, excitotoxicity, apoptotic cell death, ultimately loss functionality. The present study provides updated review concerning roles edema, inflammation, stress on changes from TBI. proper characterization phenomena contribute improvement care, rehabilitation quality life affected people.
Language: Английский
Citations
52
Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 511 - 511
Published: March 14, 2024
Neuroinflammatory and neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s (PD), traumatic brain injury (TBI) Amyotrophic lateral sclerosis (ALS) are chronic major health disorders. The exact mechanism of the neuroimmune dysfunctions these pathogeneses is currently not clearly understood. These show dysregulated inflammatory responses, activation neurons, glial cells, neurovascular unit damage associated with excessive release proinflammatory cytokines, chemokines, neurotoxic mediators, infiltration peripheral immune cells into brain, as well entry mediators through damaged endothelial blood–brain barrier tight junction proteins. Activation leads to many molecules that cause neuroinflammation neurodegeneration. Gulf War Illness (GWI) myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) also dysfunctions. Currently, there no effective disease-modifying therapeutic options available for diseases. Human induced pluripotent stem cell (iPSC)-derived astrocytes, microglia, pericytes used models drug discovery. This review highlights certain recent trends in neuroinflammatory responses iPSC-derived applications
Language: Английский
Citations
29
Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(5), P. 298 - 312
Published: April 3, 2024
Language: Английский
Citations
19
CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 29(8), P. 2236 - 2258
Published: March 8, 2023
Abstract Aims Recently, human umbilical cord mesenchymal stem cell (HucMSC)‐derived exosome is a new focus of research in neurological diseases. The present study was aimed to investigate the protective effects HucMSC‐derived both vivo and vitro TBI models. Methods We established mouse neuron models our study. After treatment with exosome, neuroprotection investigated by neurologic severity score (NSS), grip test score, brain water content, cortical lesion volume. Moreover, we determined biochemical morphological changes associated apoptosis, pyroptosis, ferroptosis after TBI. Results revealed that could improve function, decrease cerebral edema, attenuate Furthermore, administration suppressed TBI‐induced death, ferroptosis. In addition, exosome‐activated phosphatase tensin homolog‐induced putative kinase protein 1/Parkinson 2 E3 ubiquitin–protein ligase (PINK1/Parkin) pathway‐mediated mitophagy However, attenuated when inhibited, PINK1 knockdown. Importantly, also decreased activated PINK1/Parkin vitro. Conclusion Our results provided first evidence played key role through mitophagy.
Language: Английский
Citations
38
International Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown
Published: April 11, 2024
Background: Traumatic brain injury (TBI) is a serious public health burden worldwide, with mortality rate of 20%-30%; however, reducing the incidence and rates TBI remains major challenge. This study provides multidimensional analysis to explore potential breakthroughs in over past two decades. Materials Methods: We used bibliometric Latent Dirichlet Allocation (LDA) analyses analyze publications focusing on published between 2003 2022 from Web Science Core Collection (WOSCC) database identify core journals collaborations among countries/regions, institutions, authors, research trends. Results: Over 20 years, 41,545 articles 3,043 were included, 12,916 authors 20,449 institutions across 145 countries/regions. The annual number has increased ten-fold compared previous publications. revealed that high-income countries, especially United States, have significant influence. Collaboration was limited several LDA results indicated hotspots included four main areas: “Clinical finding”, “Molecular mechanism”, “Epidemiology”, “Prognosis”. Epidemiological consistently recent years. Through epidemiological topic analysis, etiology shifted traffic accidents falls demographically aging society. Conclusion: decades, developed rapidly, its epidemiology received increasing attention. Reducing preventive perspective emerging as trend alleviate future social burden; therefore, might bring TBI.
Language: Английский
Citations
9
Life, Journal Year: 2025, Volume and Issue: 15(3), P. 424 - 424
Published: March 7, 2025
Traumatic brain injury (TBI) is a leading cause of disability and death globally, presenting significant challenges for diagnosis, prognosis, treatment. As healthcare technology advances, artificial intelligence (AI) has emerged as promising tool in enhancing TBI rehabilitation outcomes. This literature review explores the current potential applications AI management, focusing on AI’s role diagnostic tools, neuroimaging, prognostic modeling, programs. AI-driven algorithms have demonstrated high accuracy predicting mortality, functional outcomes, personalized strategies based patient data. models been developed to predict in-hospital mortality patients up an 95.6%. Furthermore, enhances neuroimaging by detecting subtle abnormalities that may be missed human radiologists, expediting diagnosis treatment decisions. Despite these ethical considerations, including biases data generalizability, pose must addressed optimize implementation clinical settings. highlights key trials future research directions, emphasizing transformative improving care, rehabilitation, long-term outcomes patients.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11734 - 11734
Published: Oct. 3, 2022
This article describes commonly used experimental and clinical biomarkers of neuronal injury neurodegeneration for the evaluation neuropathology monitoring therapeutic interventions. Biomarkers are vital diagnostics brain disease monitoring. A biomarker can be objectively measured evaluated as a proxy indicator pathophysiological process or response to There complex hurdles in understanding molecular pathophysiology neurological disorders ability diagnose them at initial stages. Novel diseases may surpass these issues, especially early identification risk. Validated measure severity progression both acute chronic such epilepsy, migraine, Alzheimer’s disease, Parkinson’s Huntington’s traumatic injury, amyotrophic lateral sclerosis, multiple other diseases. deployed study treatment, including noninvasive imaging tools conditions. Neuronal classified into four core subtypes: blood-based, immunohistochemical-based, neuroimaging-based, electrophysiological biomarkers. conditions have progressive stages, inflammation, neurodegeneration, neurogenesis, which serve indices pathological status. critical targeted specific molecules, cells, tissues, proteins that dramatically alter throughout has been tremendous progress with affecting central nervous system.
Language: Английский
Citations
31
CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(6)
Published: June 1, 2024
Abstract Background Traumatic brain injury (TBI) and spinal cord (SCI) are acquired injuries to the central nervous system (CNS) caused by external forces that cause temporary or permanent sensory motor impairments potential for long‐term disability even death. These conditions currently lack effective treatments impose substantial physical, social, economic burdens on millions of people families worldwide. TBI SCI involve intricate pathological mechanisms, inflammatory response contributes significantly secondary in SCI. It plays a crucial role prolonging post‐CNS trauma period becomes focal point therapeutic intervention. Previous research has traditionally concentrated glial cells, such as astrocytes microglia. However, increasing evidence highlights involvement lymphocytes CNS injury, particularly CD8 + T cells NK along with their downstream XCL1‐XCR1 axis. Objective This review aims provide an overview axis T‐cell inflammation identify targets therapy. Methods We conducted comprehensive search PubMed Web Science using relevant keywords related axis, response, TBI, Results study examines upstream pathways involved SCI, including interleukin‐15 (IL‐15), interleukin‐12 (IL‐12), CD4 XCL1, XCR1 dendritic interferon‐gamma (IFN‐γ), helper T0 (Th0 cells), T1 (Th1 T17 (Th17 cells). describe proinflammatory effect Conclusions The findings suggest have great preclinical investigations
Language: Английский
Citations
8
Expert Review of Molecular Diagnostics, Journal Year: 2024, Volume and Issue: 24(1-2), P. 39 - 47
Published: Jan. 6, 2024
Diffuse axonal injury (DAI), with high mortality and morbidity both in children adults, is one of the most severe pathological consequences traumatic brain injury. Currently, clinical diagnosis, disease assessment, disability identification, postmortem diagnosis DAI mainly limited by absent specific molecular biomarkers.
Language: Английский
Citations
7