Disruption of Mitochondrial Quality Control in Inherited Metabolic Disorders DOI
Manuela Bianchin Marcuzzo, Josyane de Andrade Silveira, Emílio L. Streck

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Language: Английский

Mitochondrial dysfunction, oxidative stress, ER stress and mitochondria-ER crosstalk alterations in a chemical rat model of Huntington's disease: Potential benefits of bezafibrate DOI
Morgana Brondani, Ana Cristina Roginski, Rafael Teixeira Ribeiro

et al.

Toxicology Letters, Journal Year: 2023, Volume and Issue: 381, P. 48 - 59

Published: April 26, 2023

Language: Английский

Citations

18
Peroxisome proliferator-activated receptor (PPAR) agonists as a potential therapy for inherited metabolic disorders DOI
Bianca Seminotti, Mateus Grings, Nícolas Manzke Glänzel

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 209, P. 115433 - 115433

Published: Jan. 26, 2023

Language: Английский

Citations

15
The Role of Microbial Metabolites in the Progression of Neurodegenerative Diseases—Therapeutic Approaches: A Comprehensive Review DOI Open Access

Jorge Missiego-Beltrán,

Ana Isabel Beltrán-Velasco

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10041 - 10041

Published: Sept. 18, 2024

The objective of this review is to provide a comprehensive examination the role microbial metabolites in progression neurodegenerative diseases, as well investigate potential therapeutic interventions targeting microbiota. A literature search was conducted across following databases: PubMed, Scopus, Web Science, ScienceDirect, and Wiley. Key terms related gut microbiota, metabolites, specific metabolic products were used. included both preclinical clinical research articles published between 2000 2024. Short-chain fatty acids have been demonstrated play crucial modulating neuroinflammation, preserving integrity blood–brain barrier, influencing neuronal plasticity protection. Furthermore, amino their derivatives exert significant influence on CNS function. These impact health by regulating intestinal permeability, immune responses, directly neuroinflammation oxidative stress, which are integral diseases. Therapeutic strategies, including prebiotics, probiotics, dietary modifications, fecal microbiota transplantation confirmed restore balance enhance production neuroprotective metabolites. novel drug developments based present promising avenues. its represent field with advance our understanding develop treatments for

Language: Английский

Citations

6
Bezafibrate-driven mitochondrial targeting enhances antitumor immunity and prevents lung cancer via CD8+ T cell infiltration and MDSC reduction DOI Creative Commons

Jing Pan,

Jiaheng Li, Qi Zhang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 15, 2025

Bezafibrate (BEZ) is a drug used to treat hypertriglyceridemia and its long-term use has been associated with reduced risk of cancer in patients coronary artery disease. Recent studies uncovered that BEZ potent modulator mitochondrial biogenesis through activation PGC-1α/PPAR complexes, resulting modulation lipid metabolism fatty acid oxidation. Mitochondria impact virtually all processes linked oncogenesis, disruption normal bioenergetics oxidative phosphorylation (OXPHOS) occurs early during oncogenesis change the energy cells as well various tumor microenvironment (TME). Therefore, we synthesized analog (Mito-BEZ) preferentially localizes mitochondria, thereby enabling lower doses Mito-BEZ than achieve greater efficacy. Our demonstrate significantly more at inhibiting LUAD cell growth vitro lung tumorigenesis preclinical mouse models. was also >200-fold both complex I III cells. Furthermore, suppresses while markedly upregulating function effector CD8+ T cells, immune response TME. results show Mito-BEZ, favorable toxicity profile, exhibited striking inhibitory effect on progression metastasis by targeting fundamental difference metabolic plasticity between

Language: Английский

Citations

0
The mechanisms of natural products for eye disorders by targeting mitochondrial dysfunction DOI Creative Commons

Guifeng Sun,

Xin-Hui Qu, Liping Jiang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 25, 2024

The human eye is susceptible to various disorders that affect its structure or function, including glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy (DR). Mitochondrial dysfunction has been identified as a critical factor in the pathogenesis progression of disorders, making it potential therapeutic target clinic. Natural products have used traditional medicine for centuries continue play significant role modern drug development clinical therapeutics. Recently, there surge research exploring efficacy natural treating their underlying physiological mechanisms. This review aims discuss involvement mitochondrial summarize recent advances application targeting mitochondria. In addition, we describe future perspective challenges mitochondria-targeting products.

Language: Английский

Citations

2
Bezafibrate alleviates diabetes-induced spermatogenesis dysfunction by inhibiting inflammation and oxidative stress DOI Creative Commons

Mu Yang,

Lingbo Luo,

Shujuan Wu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e28284 - e28284

Published: March 1, 2024

The metabolic disorders caused by diabetes can lead to various complications, including male spermatogenesis dysfunction. Exploring effective therapeutics that attenuate mellitus (DM)-induced subfertility is of great importance. Pharmaceuticals targeting PPARα activation such as bezafibrate have been regarded an important strategy for patients with diabetes. In this study, we use streptozocin (STZ) injection establish a type 1 DM mice model and treat evaluate the effects on spermatogenic function mice. Bezafibrate treatment exhibited protective DM-induced deficiency, reflected increased testis weight, improved histological morphology testis, elevated sperm parameters, serum testosterone concentration well mRNA levels steroidogenesis enzymes. Meanwhile, testicular cell apoptosis, inflammation accumulation oxidative stress status were also shown be alleviated compared group. in vivo vitro studies, specific inhibitor knockout further used investigate role Our results indicated protection deficiency was abrogated inhibition or deletion. study suggested administration could ameliorate dysfunction may represent novel practical infertility.

Language: Английский

Citations

2
PIEZO1 as a new target for hyperglycemic stress-induced neuropathic injury: The potential therapeutic role of bezafibrate DOI Open Access
Hailin Liu, Lian Zhou, Xifeng Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116837 - 116837

Published: May 29, 2024

Hyperglycemic stress can directly lead to neuronal damage. The mechanosensitive ion channel PIEZO1 be activated in response hyperglycemia, but its role hyperglycemic neurotoxicity is unclear. of was explored by constructing a mouse model and high-glucose HT22 cell model. results showed that significantly upregulated high glucose stress. In vitro experiments have shown induces changes morphology membrane tension, key mechanism for activation. addition, upregulates serum/glucocorticoid-regulated kinase-1 (SGK1) activates through the Ca

Language: Английский

Citations

2
Protective effects of the PPAR agonist bezafibrate against disruption of redox and energy homeostasis, neuronal death, astroglial reactivity, and neuroinflammation induced in vivo by D-2-hydroxyglutaric acid in rat brain DOI
Rafael Teixeira Ribeiro, Manuela Bianchin Marcuzzo, Andrey Vinícios Soares Carvalho

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 987, P. 177186 - 177186

Published: Dec. 6, 2024

Language: Английский

Citations

2
Bezafibrate protects blood-brain barrier (BBB) integrity against traumatic brain injury mediated by AMPK DOI

Xiubao Yang,

Qingyong Chang,

Yan Wang

et al.

Neuropeptides, Journal Year: 2024, Volume and Issue: 107, P. 102450 - 102450

Published: June 22, 2024

Language: Английский

Citations

1
The mitochondria in schizophrenia with 22q11.2 deletion syndrome: From pathogenesis to therapeutic promise of targeted natural drugs DOI

Zongxiang Xiong,

Heting Wang,

Yutian Qu

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 127, P. 110831 - 110831

Published: July 13, 2023

Language: Английский

Citations

2