Advances in dietary polyphenols: Regulation of inflammatory bowel disease (IBD) via bile acid metabolism and the gut-brain axis

Food Chemistry, Journal Year: 2025, Volume and Issue: 472, P. 142932 - 142932

Published: Jan. 21, 2025

Language: Английский

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Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer’s disease

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Feb. 19, 2024

Alzheimer’s disease (AD) is a prevalent neurodegenerative that has become one of the main factors affecting human health. It serious impacts on individuals, families, and society. With development population aging, incidence AD will further increase worldwide. Emerging evidence suggests many physiological metabolic processes, such as lipid metabolism, are implicated in pathogenesis AD. Bile acids, undertakers play an important role occurrence disease. Tauroursodeoxycholic acid, endogenous bile been proven to possess therapeutic effects different diseases, including This review tries find relationship between acid metabolism AD, well explore potential taurocursodeoxycholic for this The mechanisms may include reducing deposition Amyloid-β protein, regulating apoptotic pathways, preventing tau hyperphosphorylation aggregation, protecting neuronal synapses, exhibiting anti-inflammatory properties, improving disorders. objective study shed light use tauroursodeoxycholic preparations prevention treatment with aim identifying effective targets clarifying various involved

Language: Английский

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Microglia and Gut Microbiota: A Double-Edged Sword in Alzheimer's Disease

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102515 - 102515

Published: Sept. 1, 2024

Language: Английский

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Molecular mechanism and therapeutic strategy of bile acids in Alzheimer’s disease from the emerging perspective of the microbiota–gut–brain axis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117228 - 117228

Published: July 31, 2024

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-β outside neurons and Tau protein inside neurons. Various pathological mechanisms are implicated in AD, including brain insulin resistance, neuroinflammation, endocrinal dysregulation adrenal corticosteroids. These factors collectively contribute to neuronal damage destruction. Recently, bile acids (BAs), which metabolites cholesterol, have shown neuroprotective potential against AD targeting above changes. BAs can enter systematic circulation cross blood–brain barrier, subsequently exerting effects several endogenous receptors. Additionally, interact with microbiota–gut–brain (MGB) axis improve immune neuroendocrine function during episodes. Gut microbes impact BA signaling through their involvement biotransformation. In this review, we summarize role molecular while considering MGB propose novel strategies for preventing onset progression AD.

Language: Английский

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Gut microbiota and healthy longevity

Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 2, 2024

Language: Английский

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Bile acid metabolism is altered in learning and memory impairment induced by chronic lead exposure

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134360 - 134360

Published: April 19, 2024

Language: Английский

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Gut–brain communication mediates the impact of dietary lipids on cognitive capacity

Food & Function, Journal Year: 2024, Volume and Issue: 15(4), P. 1803 - 1824

Published: Jan. 1, 2024

The effects of dietary lipids on cognition, both positive and negative, are mediated through the gut–brain axis by modulating metabolic, immune, neural, endocrine pathways.

Language: Английский

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Reverse engineering the Gut-Brain Axis and microbiome-metabolomics for symbiotic/pathogenic balance in neurodegenerative diseases

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 10, 2024

Deciphering the molecular communications along gut-brain axis can help in understanding pathophysiology of neurodegenerative diseases and exploiting gut microbiome for therapeutics. However, microbes their metabolites have a multifaceted role mediating both brain physiology pathology. There is lack how when this tipped what are those contributing factors, at local (gut) distal (neuronal) levels, that drive imbalance. Here we reviewed its context summarized different factors such as gut-microbial diversity, metabolites, native immune system integrity epithelial blood-brain barriers interconnected collectively define involvement gut-microbiome pathologies. It also underlines need multidisciplinary tools animal models to simultaneously reflect on many these better correlate with clinical observations data obtained from human biopsies fecal samples. Harnessing will herald paradigm shift medicine aging, emphasizing significance broader spectrum health disease.

Language: Английский

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Review on chronic metabolic diseases surrounding bile acids and gut microbiota: What we have explored so far

Life Sciences, Journal Year: 2023, Volume and Issue: 336, P. 122304 - 122304

Published: Nov. 26, 2023

Bile acid, the final product of cholesterol breakdown, functions as a complex regulator and signaling factor in human metabolism. Chronic metabolic diseases pose significant medical challenges. Growing research underscores bile acids' capacity to enhance metabolism via diverse pathways, regulating disorders offering treatment potential. Numerous bile-acid-triggered pathways have become targets. This review outlines acid synthesis, its role signal chronic diseases, highlights interaction with gut microbiota different conditions. Exploring host-bacteria-bile links emerges valuable future direction clinical implications.

Language: Английский

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Multidirectional associations between the gut microbiota and Parkinson’s disease, updated information from the perspectives of humoral pathway, cellular immune pathway and neuronal pathway

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Dec. 15, 2023

The human gastrointestinal tract is inhabited by a diverse range of microorganisms, collectively known as the gut microbiota, which form vast and complex ecosystem. It has been reported that microbiota-gut-brain axis plays crucial role in regulating host neuroprotective function. Studies have shown patients with Parkinson’s disease (PD) dysbiosis experiments involving germ-free mice fecal microbiota transplantation from PD revealed pathogenic PD. Interventions targeting PD, including use prebiotics, probiotics, transplantation, also efficacy treating However, causal relationship between remains intricate. This study reviewed association perspectives humoral pathway, cellular immune pathway neuronal pathway. We found interactions among are very complex, should be “multidirectional”, rather than conventionally regarded “bidirectional”. To realize application microbiota-related mechanisms clinical setting, we propose several problems addressed future study.

Language: Английский

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