Cited by Therapeutic Effect of Shikimic Acid on Heat Stress-Induced Myocardial Damage: Assessment via Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Experiments

Adverse Outcome Pathway-Based Strategies to Mitigate Ag₂Se Quantum Dot-Induced Neurotoxicity DOI

Yongshuai Yao, Zhihui Wang, Xiaoquan Huang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Silver selenide quantum dots (Ag2Se QDs) show great advantages in tumor imaging due to their excellent optical performance and good biocompatibility. However, the ultrasmall particle size of Ag2Se QDs allows them cross blood-brain barrier, thus potentially affecting central nervous system. Therefore, risk assessment response strategies for are important. The adverse outcome pathway (AOP) framework makes it possible develop management based on toxicity mechanisms. In this study, using AOP framework, we constructed causal mechanism relationship diagrams at different biological levels QD neurotoxicity. excess mitochondrial reactive oxygen species (mtROS) triggered Nod-like receptor protein 3 (NLRP3) inflammasome activation microglia was molecular initiation event (MIE). Proinflammatory mediator secretion were key events (KEs) cellular level. Neuroinflammation neuronal damage KEs organ/tissue Altered hippocampal physiology (AO) individual Based established further studies confirmed that mtROS-activated nuclear-factor-E2-related factor 2 (Nrf2)/PTEN-induced kinase 1 (PINK1)- mitophagy contributed weaken MIE. Molecular docking-assisted biology experiments demonstrated quercetin (Qu) enhanced process. This article emphasizes importance nanomaterials. Furthermore, paper guides use natural small-molecule drugs as a strategy mitigate nanomaterial-induced

Language: Английский

Citations

The role of quercetin in NLRP3-associated inflammation DOI

Jiaqi Wu,

Tongtong Lv, Yü Liu

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 22, 2024

Language: Английский

Citations

Ferroptosis, pathogenesis and therapy in AS co-depression disease DOI

Yulong Zhao,

Peng Ren,

Qiang Luo

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

Atherosclerosis (AS)-related cardiovascular disease and depression are often comorbid, with patients facing an increased risk of depression, which worsens AS. Both diseases characterized by oxidative stress lipid metabolism disorders. Ferroptosis, a form cell death iron overload harmful peroxide accumulation, is found in various diseases, including AS depression. Consistent the deposition peroxidation (LPO) that characterize ferroptosis mechanism, disturbances also crucial pathogenic mechanisms The comorbid complex, posing challenges for clinical treatment. Chinese herbs hold significant potential owing to their multi-target pharmacological effects. Therefore, this review aims investigate overload, LPO, across types, shared pathogenesis ferroptosis, research on herbal medicine targeting treatment anti-AS co-depression. This provides comprehensive understanding co-depression from perspective ferroptosis.

Language: Английский

Citations

Reshaping the Gut Microbiota: Tangliping Decoction and Its Core Blood-Absorbed Component Quercetin Improve Diabetic Cognitive Impairment DOI

Wenlan Zhang,

Chunmei Yi,

Zhijie Song

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156560 - 156560

Published: March 5, 2025

Language: Английский

Citations

Stimulation of microglia leads to a rapid antidepressant effect by triggering astrocytic P2Y1Rs and promoting BDNF-mediated neurogenesis in the hippocampus DOI

Hanxiao Wang, Xu Lu, Ying Ye

et al.

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

Is There such a Thing as Post-Viral Depression?: Implications for Precision Medicine DOI

Eun‐Sook Park, Chan Young Shin,

Se Jin Jeon

et al.

Biomolecules & Therapeutics, Journal Year: 2024, Volume and Issue: 32(6), P. 659 - 684

Published: Oct. 21, 2024

Viral infections are increasingly recognized as triggers for depressive disorders, particularly following the SARS-CoV-2 pandemic and rise of long COVID. Viruses such Herpes Simplex Virus (HSV), Epstein-Barr (EBV), Cytomegalovirus (CMV), Human Immunodeficiency (HIV) linked to depression through complex neurobiological mechanisms. These include immune system dysregulation, chronic inflammation, neurotransmitter imbalances that affect brain function mood regulation. activation leads release pro-inflammatory cytokines, resulting in neuroinflammation associated symptoms. Furthermore, specific viruses can disrupt systems, including serotonin, dopamine, glutamate, all which essential stabilization. The unique interactions different with these systems underscore need virus-specific therapeutic approaches. Current broad-spectrum treatments often overlook precise pathways involved post-viral depression, reducing their efficacy. This review emphasizes understand create tailored interventions directly address effects induced by each type virus. may immunomodulatory target persistent antiviral therapies reduce viral load, or neuroprotective strategies restore balance. Precision medicine offers promising avenues effective management virus-induced providing patient-specific approaches biological mechanisms involved. By focusing on development targeted treatments, this aims pave way a new era psychiatric care fully addresses root causes infections.

Language: Английский

Citations

Therapeutic Effect of Shikimic Acid on Heat Stress-Induced Myocardial Damage: Assessment via Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Experiments DOI

Yan Gu, Jingyi Zhang,

Haohong Zheng

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1485 - 1485

Published: Nov. 5, 2024

Background: Rising global temperatures have been linked to an increased incidence of heat stress (HS)-induced myocardial damage.

Language: Английский

Citations