Heavy arch: from inflammatory bowel diseases to metabolic disorders

Gut, Journal Year: 2024, Volume and Issue: 73(8), P. 1376 - 1387

Published: May 22, 2024

Background Metabolic disorders and inflammatory bowel diseases (IBD) have captured the globe during Westernisation of lifestyle related dietary habits over last decades. Both disease entities are characterised by complex heterogeneous clinical spectra linked to distinct symptoms organ systems which, on a first glimpse, do not many commonalities in practice. However, experimental studies indicate common backbone mechanisms metabolic gut inflammation, emerging evidence suggests an intricate interplay between IBD. Objective We depict parallels IBD diseases, easily overlooked routine. Design provide overview recent literature discuss implications morbidity patients with for researchers, clinicians healthcare providers. Conclusion The Western diet microbial perturbation serve as fuel inflammation beyond gut. syndrome increasingly affect IBD, expected negative impact both risk complications. This concept implies that tackling obesity pandemic exerts beneficial effects health.

Language: Английский

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Ambient Air Pollution and Risk of Enterotomy, Gastrointestinal Cancer, and All-Cause Mortality among 4,708 Individuals with Inflammatory Bowel Disease: A Prospective Cohort Study

Environmental Health Perspectives, Journal Year: 2023, Volume and Issue: 131(7)

Published: July 1, 2023

Background: Previous studies indicated that air pollution plausibly increases the risk of adverse outcomes in inflammatory bowel disease (IBD) via proinflammatory mechanisms. However, there is scant epidemiological data and insufficient prospective evidence assessing associations between ambient clinical IBD. Objectives: We aimed to investigate among individuals with Methods: Leveraging from UK Biobank, we included 4,708 IBD recruited period 2006–2010 this study. A land use regression model was used assess annual mean concentrations pollutants nitrogen including oxides (NOx), dioxide (NO2), particulate matter (PM) aerodynamic diameter ≤10μm (PM10) PM ≤2.5μm (PM2.5). Individuals were followed up for incident enterotomy, gastrointestinal cancer, all-cause mortality, ascertained death registry, inpatient, primary care, cancer registry data. Cox proportional hazard estimate ratios (HRs) 95% confidence intervals (CIs) magnitude associations. Results: During a follow-up 12.0 y, 265 enterotomy events, 124 420 events documented found each interquartile range (IQR) increase exposure PM2.5 associated increased (HR=1.16; CI: 1.00, 1.34, p=0.043), whereas an IQR NOx (HR=1.10; 1.01, 1.20, p=0.016), NO2 1.03, 1.29, p=0.010), PM10 (HR=1.15; 1.30, p=0.015), (HR=1.14; 1.02, 1.28, p=0.019) mortality did not observe any significant analyses. Consistent results observed subgroup sensitivity Conclusions: Ambient IBD, highlighting important role environmental health improving prognosis https://doi.org/10.1289/EHP12215

Language: Английский

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MAFLD as part of systemic metabolic dysregulation

Hepatology International, Journal Year: 2024, Volume and Issue: 18(S2), P. 834 - 847

Published: April 9, 2024

Language: Английский

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Long‐Term Risk of Inflammatory Bowel Disease With MASLD: A Large‐Scale Prospective Cohort Study in UK Biobank

Journal of Gastroenterology and Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

ABSTRACT Background Similar worsening epidemics globally have been showed in newly coined metabolic dysfunction‐associated steatotic liver disease (MASLD) and inflammatory bowel (IBD). We aimed to investigate the prospective association of MASLD, MASLD types, cardiometabolic risk factors (CMRFs) with long‐term incident IBD a large‐scale population cohort. Methods Participants free at enrollment from UK Biobank were included. Baseline was measured by fatty index together least one CMRF, based on latest AASLD/EASL criteria. type classified as pure MetALD (MASLD increased alcohol intake). Primary outcome IBD, including ulcerative colitis (UC) Crohn's (CD). Multivariable Cox regression conducted examine related associations. Results Overall, 403 520 participants (aged 56.2 ± 8.1 years, 45.6% males) Of whom, 151 578 (37.6%) considered baseline. During median 13.0 years' follow‐up, 2398 cases identified. Compared normal population, individuals significant higher associations (HR = 1.39, 95% CI: 1.21–1.60), UC 1.34, 1.13–1.58), CD 1.51, 1.20–1.89). Meanwhile, results consistent when assessing 1.43, 1.23–1.66) 1.46, 1.15–1.86). The excess more evident increase CMRFs numbers ( p trend < 0.001). Conclusion either or MetALD, combination different are all associated both CD. Additionally, there is greater number increase.

Language: Английский

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Ononin promotes radiosensitivity in lung cancer by inhibiting HIF-1α/VEGF pathway

Phytomedicine, Journal Year: 2023, Volume and Issue: 125, P. 155290 - 155290

Published: Dec. 20, 2023

In our previous study, we provided evidence that Astragalus mongholicus Bunge(AM) and its extracts possess a protective capability against radiation-induced damage, potentially mediated through the reduction of reactive oxygen species (ROS) nitric oxide (NO). However, were pleasantly surprised to discover during experimentation AM not only offers protection radiation damage but also exhibits sensitization effect. This effect may be attributed specific small molecule present in known as ononin. Currently, sensitizers are predominantly found nitrazole drugs nanomaterials, with no existing reports on properties ononin, nor underlying mechanism.

Language: Английский

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Long‐term risk of cardiovascular disease associated with MASLD and different cardiometabolic risk factors in IBD patients: A prospective cohort study

Liver International, Journal Year: 2024, Volume and Issue: 44(9), P. 2315 - 2328

Published: May 31, 2024

Abstract Background To examine the cardiovascular disease (CVD) risks associated with metabolic dysfunction‐associated steatotic liver (MASLD) and different numbers of cardiometabolic risk factors (CMRFs) in patients inflammatory bowel (IBD) based on a long‐term prospective cohort. Methods Prevalent IBD at baseline who were free CVD, cancer, alcoholic disease, cancer hepatitis B/C virus seropositive included (N = 4204). MASLD, MASLD subtypes [pure increased alcohol intake (MetALD)], lean/non‐lean CMRFs defined according to latest criteria proposed by AASLD EASL. The primary outcome was incident including ischaemic heart (IHD), failure (HF) stroke. Multivariable Cox proportional hazard models used estimate relationship. Results Overall, 1528 (36.4%) diagnosed baseline. During median 13.1‐year follow‐up, 503 CVDs identified. Compared IBD‐only, IBD‐MASLD had an CVD (HR 1.77, 95%CI: 1.26–2.49), especially those MetALD 2.34, 1.34–4.11) lean 2.30, 1.13–4.66). As number increased, significantly ( p trend <0.001), 116% 92% excess 3 2.16, 1.48–3.15) ≥4 1.92, 1.27–2.91). Similar IHD HF observed IBD‐MASLD, either pure or MetALD, as well MASLD. Conclusions is patients, greater evidently higher patients.

Language: Английский

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Skullcapflavone II induces G2/M phase arrest in hepatic stellate cells and suppresses hepatic fibrosis

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177522 - 177522

Published: March 1, 2025

Language: Английский

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Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank

BMC Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Oct. 20, 2023

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly defined condition encompassing hepatic steatosis and metabolic dysfunction. However, the relationship between MAFLD multi-system diseases remains unclear, time-dependent sequence of these requires further clarification.After propensity score matching, 163,303 subjects matched were included in community-based UK Biobank study. The International Classification Diseases, Tenth Revision (ICD-10), was used to reclassify medical conditions into 490 16 specific causes death. We conducted trajectory analysis map key pathways linking various health conditions, providing an overview their interconnections.Participants aged 59 (51-64) years, predominantly males (62.5%), During 12.9-year follow-up period, participants found have higher risk 113 eight death, determined through phenome-wide association using Cox regression models. Temporal trajectories established pairing, revealing intermediary such as asthma, diabetes, hypertension, hypothyroid tobacco abuse, diverticulosis, chronic ischemic heart disease, obesity, benign tumors, inflammatory arthritis. These primarily resulted acute myocardial infarction, disorders fluid, electrolyte, acid-base balance, infectious gastroenteritis colitis, functional intestinal disorders. Regarding death MAFLD, malignant neoplasms, cardiovascular diseases, respiratory system deaths main causes, organ failure, infective internal environment disorder primary end-stage conditions. Disease based on level genetic susceptibility yielded consistent results.Individuals with number different Notably, potential constitute many that may be promising targets for preventing general decline patients MAFLD.

Language: Английский

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Mortality risk associated with MASLD, MASLD type and different cardiometabolic risk factors in IBD patients: A long-term prospective cohort study

Digestive and Liver Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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Lean MASLD and IBD: Exploring the Intersection of Metabolic Dysfunction and the Gut–Liver Axis

Life, Journal Year: 2025, Volume and Issue: 15(2), P. 288 - 288

Published: Feb. 12, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) challenges traditional paradigms by manifesting in lean individuals. The link between MASLD and inflammatory bowel (IBD) underscores the importance of gut-liver axis progression chronic inflammation. This study evaluates prevalence, clinical characteristics, diagnostic predictors individuals with without IBD. prospective included 387 patients. Hepatic steatosis fibrosis were assessed using vibration-controlled transient elastography (VCTE). Anthropometric, biological data compared. subgroup analyses focused on patients was present 34.1% 46.3% those who had increased visceral adiposity (CUN-BAE: 31.21 ± 5.42 vs. 24.57 6.49, p < 0.001) metabolic dysfunction, including dyslipidemia elevated fasting glucose. IBD-MASLD exhibited greater hepatic systemic CUN-BAE outperformed FLI HSI predicting steatosis, especially IBD (AUC = 0.806). Lean MASLD, particularly patients, highlights need for tailored management strategies. plays a key role progression, index demonstrates superior accuracy identifying steatosis.

Language: Английский

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