Association Between Liver Fibrosis (FIB-4) Index and Vertebral Fracture in Middle-aged and Older Adults in the United States: A Cross-Sectional Study of NHANES 2013-2014

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Objective This study was to examine the association between FIB-4(fibrosis index based on four factors) and occurrence of vertebral fractures in Middle-aged Older Americans. Methods Patients ⩾45years age from 2013–2014 NHANES database were selected for this study. Restricted cubic spline models weighted logistic regression used assess FIB-4 The predictive value assessed using receiver operating characteristic curves (ROC). To robustness main findings, a sensitivity analysis conducted. Results A total 2188 patients included analysis, whole 147 suffered fractures. Fully adjusted showed significant linear relationship fracture Americans (P < 0.05),with observed risk Additionally, demonstrated good performance incidence Conclusions found that index, as novel non-invasive liver fibrosis biomarker, can predict middle-aged older Americans, which has clinical significance prevention management

Language: Английский

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The Current Status of the Liver Liquid Biopsy in MASH Related HCC: Overview and Future Directions

Biomolecules, Journal Year: 2023, Volume and Issue: 13(9), P. 1369 - 1369

Published: Sept. 9, 2023

Metabolic dysfunction-associated steatohepatitis (MASH) is one of the major risk factors for chronic liver disease and hepatocellular carcinoma (HCC). The incidence MASH in Western countries continues to rise, driving HCC as third cause cancer-related death worldwide. has become a global health challenge, partly from obesity epidemic promoting metabolic cellular disturbances but also paucity biomarkers its early detection. Over 50% cases are clinically present at late stage, where curative measures no longer beneficial. Currently, there both specific sensitive biological markers early-stage detection HCC. search diagnosis high-risk populations intense. We described potential role surrogates biopsy screening monitoring patients nesting

Language: Английский

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Bone mass, microarchitecture and turnover among young Indian women with non-alcoholic fatty liver disease

Endocrine, Journal Year: 2024, Volume and Issue: 86(2), P. 790 - 799

Published: June 24, 2024

Language: Английский

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Environmental Cadmium Exposure Exacerbated Bone Loss in NAFLD Mice

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 202(10), P. 4586 - 4595

Published: Dec. 15, 2023

Language: Английский

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Liver-based inter-organ communication: A disease perspective

Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122824 - 122824

Published: June 9, 2024

Language: Английский

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Methods for estimating insulin resistance from untargeted metabolomics data

Metabolomics, Journal Year: 2023, Volume and Issue: 19(8)

Published: Aug. 9, 2023

Insulin resistance is associated with multiple complex diseases; however, precise measures of insulin are invasive, expensive, and time-consuming.Develop estimation models for resistance, including sensitivity index (SI) homeostatic model assessment (HOMA-IR) from metabolomics data.Insulin Resistance Atherosclerosis Family Study (IRASFS).Community based.Mexican Americans (MA) African (AA).Estimation i.e. SI HOMA-IR.Least Absolute Shrinkage Selection Operator (LASSO) Elastic Net regression were used to build 1274 metabolites combined clinical data, e.g. age, sex, body mass (BMI). Metabolite data transformed using three approaches, inverse normal transformation, standardization, Box Cox transformation. The analysis was performed in one MA recruitment site (San Luis Valley, Colorado (SLV); N = 450) tested another Antonio, Texas (SA); 473). In addition, the two sites AA sample (Los Angeles, California; 495). Estimated empiric correlated SA (r2 0.77) 0.74) testing datasets. Further, estimated consistently BMI, low-density lipoprotein cholesterol (LDL), triglycerides. We applied similar approaches estimate HOMA-IR results.We have developed a method estimating that has potential application wide range biomedical studies conditions.

Language: Английский

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Effects of Exercise on Bone Marrow Adipose Tissue in Children With Overweight/Obesity: Role of Liver Fat

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 7, 2024

Abstract Context Exercise reduces adiposity, but its influence on bone marrow fat fraction (BMFF) is unknown; nor it known whether a reduction in liver content mediates this reduction. Objectives This work aimed to determine incorporating exercise into lifestyle program the lumbar spine (LS) BMFF and investigate changes mediate any such effect. Methods Ancillary analysis of 2-arm, parallel, nonrandomized clinical trial was conducted at primary care centers Vitoria-Gasteiz, Spain. A total 116 children with overweight/obesity were assigned 22-week family-based (control group [n = 57]) or same plus an intervention (exercise 59]). The compared interventions consisted (two 90-minute sessions/month) supervised (three sessions/week). outcome examined change LS-BMFF between baseline 22 weeks, as estimated by magnetic resonance imaging. effect hepatic also recorded. Results Mean weight loss difference groups 1.4 ± 0.5 kg favor group. Only experienced (effect size [Cohen d] −0.42; CI, −0.86 −0.01). Importantly, 40.9% reductions mediated percentage (indirect effect: β=−0.104; 95% −0.213 −0.019). independent loss. Conclusion addition designed reduce cardiometabolic risk improves health reducing overweight obesity. beneficial appears be fat.

Language: Английский

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Liver and bone in tandem: osteopenia as an inevitable companion to non-alcoholic fatty liver disease

Russian Journal of Evidence-Based Gastroenterology, Journal Year: 2024, Volume and Issue: 13(4), P. 40 - 40

Published: Jan. 1, 2024

Language: Английский

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