Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155784 - 155784
Published: Dec. 20, 2024
Language: Английский
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155784 - 155784
Published: Dec. 20, 2024
Language: Английский
Cellular Signalling, Journal Year: 2022, Volume and Issue: 101, P. 110493 - 110493
Published: Oct. 11, 2022
Language: Английский
Citations
30Life Sciences, Journal Year: 2022, Volume and Issue: 308, P. 120974 - 120974
Published: Sept. 17, 2022
Language: Английский
Citations
29Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2411 - 2411
Published: Aug. 28, 2023
This comprehensive review elucidates the intricate roles of long non-coding RNAs (lncRNAs) within colorectal cancer (CRC) microenvironment, intersecting domains immunity, intercellular communication, and therapeutic potential. lncRNAs, which are significantly involved in pathogenesis CRC, immune evasion, treatment response to have crucial implications inflammation serve as promising candidates for novel strategies biomarkers. scrutinizes interaction lncRNAs with Consensus Molecular Subtypes (CMSs) their complex interplay tumor stroma affecting immunity inflammation, conveyance via extracellular vesicles, particularly exosomes. Furthermore, we delve into relationship between other RNAs, including microRNAs circular mediating cell-to-cell communication CRC microenvironment. Lastly, propose potential manipulate enhance anti-tumor thereby underlining significance devising innovative interventions CRC.
Language: Английский
Citations
19Clinical & Translational Oncology, Journal Year: 2022, Volume and Issue: 25(1), P. 21 - 32
Published: July 6, 2022
Language: Английский
Citations
24Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 249, P. 154756 - 154756
Published: Aug. 10, 2023
Language: Английский
Citations
15Clinical & Translational Oncology, Journal Year: 2023, Volume and Issue: 25(7), P. 2015 - 2042
Published: Feb. 28, 2023
Language: Английский
Citations
11Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Language: Английский
Citations
0Cancer Cell International, Journal Year: 2022, Volume and Issue: 22(1)
Published: Nov. 4, 2022
Abstract Colorectal cancer (CRC) is a gastrointestinal tumor that develops from the colon, rectum, or appendix. The prognosis of CRC patients especially those with metastatic lesions remains unsatisfactory. Although various conventional methods have been used for treatment CRC, early detection and identification molecular mechanisms associated necessary. scientific literature reports altered expression long non-coding RNAs (lncRNAs) contributed to pathogenesis cells. LncRNA TUG1 was reported target miRNAs signaling pathways mediate cell proliferation, migration, metastasis. Therefore, might be potent predictive/prognostic biomarker diagnosis CRC.
Language: Английский
Citations
13Gene, Journal Year: 2023, Volume and Issue: 897, P. 148040 - 148040
Published: Dec. 6, 2023
Language: Английский
Citations
7iScience, Journal Year: 2023, Volume and Issue: 26(9), P. 107673 - 107673
Published: Aug. 18, 2023
Long noncoding RNA (lncRNA) plays crucial roles in the development of gastric cancer (GC); however, studies their mechanisms action are needed to determine clinical value. The aim this study is explore effects and THUMPD3-AS1 GC. Elevated levels were observed GC demonstrated a significant positive correlation with poor prognosis. Functionally, promoted cell proliferation, migration, invasion, epithelial-mesenchymal transition (EMT) induced tumor growth vivo. exerts its regulatory function on BCAT1 through competitive binding miR-1297. Further investigations confirmed that both miR-1297 interact BCAT1. These findings suggest promotes invasion EMT by regulating miR-1297/BCAT1 pathway, indicating may serve as biomarker therapeutic target for
Language: Английский
Citations
6