Oral Submucous Fibrosis: Etiological Mechanism, Malignant Transformation, Therapeutic Approaches and Targets

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4992 - 4992

Published: March 5, 2023

Oral submucosal fibrosis (OSF) is a chronic, progressive and potentially malignant oral disorder with high regional incidence rate. With the development of disease, normal function social life patients are seriously affected. This review mainly introduces various pathogenic factors mechanisms OSF, mechanism transformation into squamous cell carcinoma (OSCC), existing treatment methods new therapeutic targets drugs. paper summarizes key molecules in miRNAs lncRNAs abnormal changes, natural compounds effects, which provides molecular further research directions for prevention OSF.

Language: Английский

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Targeting oral tumor microenvironment for effective therapy

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: May 23, 2023

Oral cancers are among the common head and neck malignancies. Different anticancer therapy modalities such as chemotherapy, immunotherapy, radiation therapy, also targeted molecular may be prescribed for targeting oral Traditionally, it has been assumed that malignant cells alone by chemotherapy radiotherapy suppresses tumor growth. In last decade, a large number of experiments have confirmed pivotal role other secreted molecules in microenvironment (TME) on progression. Extracellular matrix immunosuppressive tumor-associated macrophages, myeloid-derived suppressor (MDSCs), cancer-associated fibroblasts (CAFs), regulatory T (Tregs) play key roles progression tumors like resistance to therapy. On hand, infiltrated CD4 + CD8 lymphocytes, natural killer (NK) anti-tumor suppress proliferation cells. Modulation extracellular cells, stimulation immunity suggested treat malignancies more effectively. Furthermore, administration some adjuvants or combination this review, we discuss various interactions between cancer TME. review basic mechanisms within TME cause Potential targets approaches overcoming will reviewed. The findings potential therapeutic clinical studies

Language: Английский

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Precursor Lesions, Overdiagnosis, and Oral Cancer: A Critical Review

Cancers, Journal Year: 2024, Volume and Issue: 16(8), P. 1550 - 1550

Published: April 18, 2024

Despite the profession placing great emphasis on oral potentially malignant disorders (OPMDs) as a gateway for early recognition and consequently better outcomes cancer, death rates lip cavity cancer have remained stagnant three decades. Evidence shows that only small fraction of cancers are in fact preceded by OPMDs, most OPMDs an annual transformation rate less than 1%. As encompass very heterogeneous group conditions, it could be argued patients with mucosal diseases bearing substantial risk warrant close surveillance treatment, these include proliferative leukoplakia, erythroplakia, non-homogeneous well presenting severe dysplasia at biopsy. In this narrative review, I discuss intricate epidemiology malignancies we colloquially refer to explore limitations focusing reduce incidence mortality argue may-be label represents overdiagnosis OPMDs.

Language: Английский

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Diagnostic Criteria for Oral Epithelial Dysplasia: Predicting Malignant Transformation

Head and Neck Pathology, Journal Year: 2025, Volume and Issue: 19(1)

Published: Feb. 7, 2025

Language: Английский

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Targeting anticancer immunity in oral cancer: Drugs, products, and nanoparticles

Environmental Research, Journal Year: 2023, Volume and Issue: 239, P. 116751 - 116751

Published: July 27, 2023

Language: Английский

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Diseases with oral malignant potential: Need for change to inform research, policy, and practice

Journal of Oral Pathology and Medicine, Journal Year: 2024, Volume and Issue: 53(8), P. 495 - 501

Published: Aug. 5, 2024

This manuscript critically examines the current classification of oral potentially malignant disorders, questioning practicality and implications labeling such a large population as precancerous, given that actual progression to cancer is significantly low for most disorders. The paper advocates revised system accurately reflects varying malignancy risks associated with different It suggests reassessment diagnostic management approaches mitigate overdiagnosis alleviate patient burdens. We propose categorizing diseases potential follows: Oral Precancerous Diseases, encompassing high-risk lesions conditions like erythroplakia, non-homogeneous leukoplakia, proliferative actinic keratosis; Potentially Premalignant covering lesions, conditions, systemic distinct manifestations harboring limited or undefined risk transformation, homogeneous submucous fibrosis, lichenoid diseases, chronic hyperplastic candidosis, keratosis known aetiology (smokeless tobacco, khat), palatal in reverse smokers, dyskeratosis congenita; Systemic Conditions Malignant Potential including Fanconi's anemia, xeroderma pigmentosum, immunosuppression (including patients post-bone marrow transplantation), which are an increased without preceding precursor lesions. provide illustrative examples demonstrate how this framework offers practical guidance research, policy-making, clinical practice.

Language: Английский

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Exosomes derived from human adipose mesenchymal stem cells act as a therapeutic target for oral submucous fibrosis

Journal of Stomatology Oral and Maxillofacial Surgery, Journal Year: 2025, Volume and Issue: 126(3), P. 102224 - 102224

Published: Jan. 5, 2025

Language: Английский

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Family Medicine Residents' Competency to Manage Oral Lesions: An Educational Intervention

Oral Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Head and neck cancer is the seventh most prevalent in world, of which majority are squamous cell carcinomas (Mody et al. 2021). The term oral refers to malignancies lip, tongue, mouth (oral cavity) [ICD-10: C00-06]. According GLOBOCAN 2020 report, approximately 370.000 new cases lip cavity were diagnosed 2020, with 170.000 recorded deaths associated it (Sung Despite being relatively accessible for routine physical examination by clinicians, advanced stages disease (Stathopoulos Smith 2017). In patients cancer, clinical stage at time diagnosis a critical predictor recurrence mortality (Kowalski Carvalho 2001). Oral potentially malignant disorders (OPMDs) defined as "any mucosal abnormality that statistically increased risk developing cancer" (Warnakulasuriya global prevalence OPMDs estimated be 4.47% (Mello 2018). Clinicians should carefully monitor prevent potential progression cancer. Malignant transformation (MT) rates vary among regular follow-up can lead earlier detection event MT, ultimately leading improved survival (Jäwert Primary healthcare centers frequently accommodate health-related problems family doctors responsible making precise decisions concerning lesions. primary care settings, examinations performed general practitioners, medicine residents (FMRs), or specialists. A doctor must possess necessary skills knowledge pre-diagnose an cavity. This study aimed evaluate effects 1-week educational intervention on levels competency managing lesions FMRs. All FMRs eastern region Istanbul, Türkiye invited study. from Pendik district (n = 60) formed group (IG), whereas Kartal 50) control (CG). Volunteers received pretest containing lesion pre-diagnosis management measurement form comprising 50 questions based 25 visual cases. include: five anatomy nonpathological lesions; ten benign seven three selected accordance 2021 World Health Organization (WHO) classification 2021) 2022 WHO head tumors (Muller Tilakaratne 2022). Case images sourced open-access publications utilized Creative Commons licenses, allowing unrestricted usage their content. Following (see Data S1) began IG. After training program S2) 3 months later; same was reapplied posttest retention-test respectively assess short- long-term intervention. CG underwent tests, without Ninety-seven completed scores revealed no significant differences (p > 0.05). Post-intervention, observed between both groups all categories retention test < 0.001). IG 48) achieved average total score 82.52 ± 6.58 points posttest, compared 61.48 9.32 out 100 indicating increase 49) 62.06 11.02 62.57 11.38 pretest. 80.65 6.79 test, 0.073) 63.02 11.45 0.121). Similar scores, difference found 0.001) S3). short focused significantly enhance FMRs' ability manage Çetin Batuhan Öçbe: conceptualization, writing – original draft, methodology, formal analysis, data curation, review editing, resources. Melisa visualization, investigation, validation. Mehmet Akman: validation, project administration, supervision, conceptualization. authors have nothing report. quasi-experimental controlled interventional granted ethical approval Marmara University Faculty Medicine Non-Interventional Clinical Ethics Committee under application number: 0920221254. procedures used this adhere tenets Declaration Helsinki. No incentives rewards offered volunteers. Both individually informed about responsibilities, they each signed specific consent forms join include publication results after anonymization scientific purposes. declare conflicts interest. tests during online Supporting Information. underlying article supplementary material will shared reasonable request corresponding author. S1: designed improve Family Residents' S2: Lesion Pre-diagnosis Management Competency Measurement Form. S3: Average correct percentages. Please note: publisher not content functionality any supporting information supplied authors. Any queries (other than missing content) directed author article.

Language: Английский

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Transformers, convolutional neural networks, and few-shot learning for classification of histopathological images of oral cancer

Expert Systems with Applications, Journal Year: 2023, Volume and Issue: 241, P. 122418 - 122418

Published: Nov. 7, 2023

Language: Английский

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Drug treatment for oral submucous fibrosis: an update

BMC Oral Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 12, 2023

Abstract Objective The aim of this review is to evaluate the different medicinal interventions available for management oral submucous fibrosis (OSF). Materials and methods We conducted a comprehensive electronic search on PubMed, Web Science, Cochrane Library databases articles related OSF patients treated with medications from December 2011 September 2022. GRADE system was used evidence quality. reporting systematic in accordance Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) protocol. main outcomes were improvement maximum mouth opening, burning sensation, cheek flexibility, tongue protrusion. Results Twenty-nine randomized controlled trials (RCTs), five clinical (CCTs) included, use drugs treatment evaluated. Drugs like steroids, hyaluronidase, pentoxifylline, lycopene, curcumin, dpirulina, aloe vera, omega3, oxitard, allicin, colchicine have been used. It found that high quality salvia miltiorrhiza combined triamcinolone acetonide, those moderate colchicine, omega 3, oxitard. Conclusion Based results our analysis, long-term treatment, we lycopene low side effects, whereas relieving symptoms severe vera most effective. Although recent has made some progress, drug therapy remains unclear, more high-quality RCTs are needed identify better treatments OSF.

Language: Английский

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