Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies DOI Creative Commons
M. Prabhavi N. Perera, Efstathia S Gotsis, Neil W. Bailey

et al.

Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(8)

Published: Aug. 1, 2024

Abstract Obsessive-compulsive disorder (OCD) is a debilitating psychiatric condition that difficult to treat due our limited understanding of its pathophysiology. Functional connectivity in brain networks, as evaluated through neuroimaging studies, plays pivotal role OCD. While both electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) have been extensively employed OCD research, few fully synthesized their findings. To bridge this gap, we reviewed 166 studies (10 EEG, 156 fMRI) published up December 2023. In EEG exhibited lower delta alpha bands, with inconsistent findings other frequency bands. Resting-state fMRI reported conflicting patterns within the default mode network (DMN) sensorimotor cortico-striato-thalamo-cortical (CSTC) circuitry. Many observed decreased resting-state between DMN salience (SN), implicating 'triple model' Task-related hyperconnectivity DMN-SN hypoconnectivity SN frontoparietal suggest OCD-related cognitive inflexibility, potentially triple dysfunction. conclusion, review highlights diverse differences OCD, revealing complex interplay contributes symptom manifestation. However, presence underscores necessity for targeted research achieve comprehensive pathophysiology

Language: Английский

Dysregulated connectivity configuration of triple-network model in obsessive-compulsive disorder DOI
Hailong Li, Bin Li, Lingxiao Cao

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

Citations

0
Brain Network Abnormalities in Obsessive–Compulsive Disorder: Insights from Edge Functional Connectivity Analysis DOI Creative Commons

Yong Xu,

H. MEI LIU,

Haiyan Liu

et al.

Behavioral Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 488 - 488

Published: April 8, 2025

Functional differences in key brain networks, including the dorsal attention network (DAN), control (CN), and default mode (DMN), have been identified individuals with obsessive–compulsive disorder (OCD). However, precise nature of these remains unclear. In this study, we further explored validated previous findings using a novel edge functional connectivity (eFC) approach, which enables more refined analysis interaction. By employing advanced method, sought to gain deeper insights into FC alterations that may underlie pathology OCD. We collected data during movie watching from 44 patients OCD 33 healthy controls (HCs). The two-sample t test was used assess entropy between DAN, CN, DMN groups. performed for potentially confounding variables ensure robustness findings. Significant were found HC Relative HCs, showed significantly reduced DAN increased CN DMN. decreased observed study be related core symptoms OCD, such as deficit, impaired cognitive control, self-referential thinking. These results provide valuable neurobiological mechanisms highlight potential biomarker disorder. Future research should explore relationship changes severity symptoms, well their implications development treatment strategies.

Language: Английский

Citations

0
Neuroimaging biomarkers: a critical review of their role in neurological disease diagnosis and management DOI
Nitu L. Wankhede, Sushruta Koppula,

Payal D. Umare

et al.

Brain Disorders, Journal Year: 2025, Volume and Issue: 18, P. 100222 - 100222

Published: April 21, 2025

Language: Английский

Citations

0
Effects of antidepressants on brain structure and function in patients with obsessive-compulsive disorder: A review of neuroimaging studies DOI Creative Commons
Homa Seyedmirzaei,

Nikoo Bayan,

Mohammad Amin Dabbagh Ohadi

et al.

Psychiatry Research Neuroimaging, Journal Year: 2024, Volume and Issue: 342, P. 111842 - 111842

Published: June 6, 2024

Obsessive-compulsive disorder (OCD) affects 2-3% of people worldwide. Antidepressants treatment is one the standard treatments OCD. effects on brain patients with OCD have not yet been fully assessed. We conducted a systematic search PubMed, Scopus, Embase, and Web Science to explore antidepressants neuroimaging findings in Thirteen investigations were included. After antidepressant treatment, structural magnetic resonance imaging studies suggested thalamic, amygdala, pituitary volume changes patients. In addition, use was associated alterations diffusion tensor metrics left striatum, right midbrain, posterior thalamic radiation parietal lobe. Finally, functional highlighted possible ventral frontal, prefrontal cortex. The small number included sample sizes, short durations follow-up, different antidepressants, variable regions interest, heterogeneous samples limit robustness present review. conclusion, our review suggests that therapy individuals OCD, these results may help deepen knowledge pathophysiology mechanisms underlying antidepressants.

Language: Английский

Citations

2
Metaanalysis of Repetitive Transcranial Magnetic Stimulation (rTMS) Efficacy for OCD Treatment: The Impact of Stimulation Parameters, Symptom Subtype and rTMS-Induced Electrical Field DOI Open Access
Fateme Dehghani-Arani, Reza Kazemi, Amir‐Homayun Hallajian

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(18), P. 5358 - 5358

Published: Sept. 10, 2024

Background: Repetitive transcranial magnetic stimulation (rTMS) has recently demonstrated significant potential in treating obsessive-compulsive disorder (OCD). However, its effectiveness depends on various parameters, including OCD subtypes and electrical fields (EFs) induced by rTMS targeted brain regions that are less studied. Methods: Using the PRISMA approach, we examined 27 randomized control trials (RCTs) conducted from 1985 to 2024 using for treatment of several meta-analyses investigate role EFs each protocol, efficacy. Results: A significant, medium effect size was found, favoring active (gPPC = 0.59, p < 0.0001), which larger obsession subscale. Both supplementary motor area (SMA) 0.82, 0.048) bilateral dorsolateral prefrontal cortex (DLPFC) 1.14, 0.04) large sizes, while right DLPFC showed a moderate reducing severity 0.63, 0.012). These protocols largest dorsal cognitive, ventral cognitive sensorimotor circuits. targeting produced strongest circuits, pre-supplementary (pre-SMA) orbitofrontal (OFC) linked emotional affective processing addition The pre-SMA modulated more circuits involved pathophysiology—sensorimotor, affective, frontolimbic—with than other protocols. Conclusions: While shows overall clinical efficacy, demonstrate highest potential. appears induce relevant pathophysiology.

Language: Английский

Citations

2
Quantification of glutathione and its associated spontaneous neuronal activity in major depressive disorder and obsessive-compulsive disorder DOI
Sang Won Lee, Seungho Kim, Yongmin Chang

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: 97(3), P. 279 - 289

Published: Aug. 30, 2024

Language: Английский

Citations

1
Functional MRI-Specific Alternations in default mode network in obsessive–compulsive disorder: A voxel-based meta-analysis DOI Creative Commons

Jianping Yu,

Qianwen Xu,

Lisha Ma

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

1
The Effect of Symptom-Provocation on Inhibitory Control in Obsessive-Compulsive Disorder Patients Is Contingent upon Chronotype and Time of Day DOI Open Access
Omer Linkovski, Hadar Naftalovich, David Mor

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(12), P. 4075 - 4075

Published: June 15, 2023

Studies have shown that alertness can affect inhibitory control, the mechanism responsible for stopping behaviors, thoughts, or emotions. Inhibitory control is particularly important helping individuals with Obsessive-Compulsive Disorder (OCD) resisting their symptoms. Chronotype governing an individual's fluctuation of throughout day. Previous studies a 'morning' chronotype worse OCD symptoms in evening and vice versa. We administered novel 'symptom-provocation stop signal task' (SP-SST), which individually tailored triggers were presented was measured. Twenty-five treatment-seeking patients completed SP-SST three times per day seven consecutive days. Stop reaction time (SSRT), measures calculated separately symptom-provocation trials neutral trials. Results yielded that: (a) significantly harder compared to trials, (b) by time-of-day interaction predicts inhibition both indicating better optimal Furthermore, we concluded detrimental effect on control. Most importantly, higher levels, be predicted day, general specifically.

Language: Английский

Citations

2
The occurrence and severity of obsessive-compulsive disorder in the opium and amphetamine users DOI
Abdollah Farhadi Nasab, Seyedshahab Banihashem, Morvarid Alishah

et al.

Journal of Substance Use, Journal Year: 2024, Volume and Issue: 29(6), P. 1217 - 1220

Published: May 26, 2024

Objective Simultaneous occurrence of psychological disorders such as obsessive-compulsive disorder (OCD) has been reported in patients with a history substance abuse. We evaluated the and severity OCD opium amphetamine users.

Language: Английский

Citations

0
Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies DOI Creative Commons
M. Prabhavi N. Perera, Efstathia S Gotsis, Neil W. Bailey

et al.

Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(8)

Published: Aug. 1, 2024

Abstract Obsessive-compulsive disorder (OCD) is a debilitating psychiatric condition that difficult to treat due our limited understanding of its pathophysiology. Functional connectivity in brain networks, as evaluated through neuroimaging studies, plays pivotal role OCD. While both electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) have been extensively employed OCD research, few fully synthesized their findings. To bridge this gap, we reviewed 166 studies (10 EEG, 156 fMRI) published up December 2023. In EEG exhibited lower delta alpha bands, with inconsistent findings other frequency bands. Resting-state fMRI reported conflicting patterns within the default mode network (DMN) sensorimotor cortico-striato-thalamo-cortical (CSTC) circuitry. Many observed decreased resting-state between DMN salience (SN), implicating 'triple model' Task-related hyperconnectivity DMN-SN hypoconnectivity SN frontoparietal suggest OCD-related cognitive inflexibility, potentially triple dysfunction. conclusion, review highlights diverse differences OCD, revealing complex interplay contributes symptom manifestation. However, presence underscores necessity for targeted research achieve comprehensive pathophysiology

Language: Английский

Citations

0