Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1098 - 1098

Published: Jan. 27, 2025

This article reviews the synergistic effects of antioxidant-enriched functional foods and exercise in improving metabolic health, focusing on underlying molecular mechanisms. The review incorporates evidence from PubMed, SCOPUS, Web Science, PsycINFO, reference lists relevant up to 20 December 2024, highlighting central role Nrf2 pathway. As a critical regulator oxidative stress adaptation, mediates benefits these interventions. presents an innovative approach understanding regulation inflammation, its potential prevention treatment various diseases, including cancer, neurodegenerative disorders, cardiovascular pulmonary diabetes, inflammatory conditions, ageing, infections such as COVID-19. novelty this study is investigate bioactive compounds found (such polyphenols, flavonoids, vitamins) exercise-induced activation combined reveals their improve insulin sensitivity lipid metabolism reduce offering promising strategy for management chronic diseases. However, there are significant gaps current research, particularly regarding mechanisms interaction between diet, physical activity, activation, well long-term different populations, those with In addition, interactions other signalling pathways, AMPK, NF-κB, PI3K/Akt, collective contributions health explored. Furthermore, novel biomarkers presented assess impact strategies, NAD+/NADH ratio, GSH markers mitochondrial health. findings provide valuable insights into how integration antioxidant-rich diet regular can by activating related pathways represent strategies disorders. Further studies needed fully understand therapeutic interventions diseases stress, disease, cancer.

Language: Английский

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Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102119 - 102119

Published: Nov. 4, 2023

Language: Английский

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Antiviral, anti-inflammatory and antioxidant effects of curcumin and curcuminoids in SH-SY5Y cells infected by SARS-CoV-2

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 10, 2024

COVID-19, caused by SARS-CoV-2, affects neuronal cells, causing several symptoms such as memory loss, anosmia and brain inflammation. Curcuminoids (Me08 e Me23) curcumin (CUR) are derived from Curcuma Longa extract (EXT). Many therapeutic actions have been linked to these compounds, including antiviral action. Given the severe implications of especially within central nervous system, our study aims shed light on potential curcuminoids against SARS-CoV-2 infection, particularly in cells. Here, we investigated effects CUR, EXT, Me08 Me23 human neuroblastoma SH-SY5Y. We observed that significantly decreased expression plasma membrane-associated transmembrane protease serine 2 (TMPRSS2) TMPRSS11D, consequently mitigating elevated ROS levels induced SARS-CoV-2. Furthermore, exhibited antioxidative properties increasing NRF2 gene restoring NQO1 activity following infection. Both effectively reduced replication SH-SY5Y cells overexpressing ACE2 (SH-ACE2). Additionally, all compounds demonstrated ability decrease proinflammatory cytokines IL-6, TNF-α, IL-17, while specifically INF-γ levels. Our findings suggest curcuminoid could serve a agent for impact context system involvement.

Language: Английский

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The classical and non-classical axes of renin-angiotensin system in Parkinson disease: The bright and dark side of the moon

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 94, P. 102200 - 102200

Published: Jan. 17, 2024

Language: Английский

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NRF2 Antioxidant Response and Interferon‐Stimulated Genes Are Differentially Expressed in SARS‐CoV‐2‐Positive Young Subjects

Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

ABSTRACT Background Several respiratory viruses, including Severe Acute Respiratory Syndrome‐Coronavirus‐2 (SARS‐CoV‐2), suppress nuclear factor‐E2‐related factor‐2 (NRF2) antioxidant response, generating oxidative stress conditions to its advantage. NRF2 has also been reported regulate the innate immune response through inhibition of interferon (IFN) pathway. However, modulation in younger individuals and correlation with IFN remain be elucidated. Methods The redox‐related genes expression was examined nasopharyngeal swabs from children attending pediatric hospital for SARS‐CoV‐2 molecular testing. Expression levels were analyzed by stratifying population according positivity, age, or presence symptoms. results correlated Types I III IFN‐stimulated (ISGs). Results We found that markedly diminished positive patients compared negative. Moreover, it higher IFNα2 IFNλ3, as well ISG15 ISG56. Interestingly, symptomatic anosmia/ageusia showed pronounced apurinic/apyrimidinic endonuclease1/redox factor 1 (APE1), together Type IFNs, ISG56, inflammasome component NLRP3. Conclusion indicate an interdependence between pathway IFN‐mediated during infection young subjects.

Language: Английский

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Pharmacological characterization of the antidiabetic drug metformin in atherosclerosis inhibition: A comprehensive insight

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(8)

Published: Aug. 1, 2024

Abstract Background Atherosclerosis (AS) is a progressive disease that interferes with blood flow, leading to cardiovascular complications such as hypertension, ischemic heart disease, stroke, and vascular ischemia. The progression of AS correlated inflammation, oxidative stress, endothelial dysfunction. Various signaling pathways, like nuclear erythroid‐related factor 2 (Nrf2) Kruppel‐like (KLF2), are involved in the pathogenesis AS. Nrf2 KLF2 have anti‐inflammatory antioxidant properties. Thus, activation these pathways may reduce development Metformin, an insulin‐sensitizing drug used management type diabetes mellitus (T2DM), increases expression KLF2. common long‐term macrovascular complication T2DM. metformin, through its pleiotropic effect, attenuate Aims Therefore, this review aims investigate possible role metformin concerning effect on inhibition reactive oxygen species (ROS) formation. In addition antidiabetic can morbidities mortalities compared other agents, even similar glucose control by Nrf2/KLF2 pathway activation. Conclusion conclusion, effective therapeutic strategy against AS, mainly KLF2/Nrf2 axis.

Language: Английский

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Mitigating fatigue in long COVID patients with MYPplus: a clinical observation

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 26, 2025

The COVID-19 pandemic has led to the emergence of a secondary public health crisis known as Long COVID. It is estimated that approximately 10% individuals who contact develop COVID, with fatigue and brain fog being among most commonly reported debilitating symptoms. However, no standardized or effective treatments are currently available. This observational study aimed evaluate efficacy MYPplus, an herbal formulation composed Astragali Radix, Salviae Aquilariae Lignum, in alleviating patients Subjects score 60 higher on Modified Korean version Chalder Fatigue scale (mKCFQ11) rating 5 visual analogue (VAS) took two capsules MYPplus (500 mg per capsule) twice daily for 4 weeks. Changes symptoms were assessed using mKCFQ11, Multidimensional Inventory (MFI-20), VAS, Brain overall quality life Short-Form Health Survey (SF-12). Additionally, levels three cytokines (TNF-α, TGF-β, IFN- γ) cortisol measured. Fifty participants successfully completed 4-week administration MYPplus. At baseline, severity was 75.3 ± 10.9 70.9 11.2 MFI-20, 7.5 1.2 8.4 1.1 45.3 17.8 SF-12. All parameters significantly improved (p < 0.01), decrease 46% 26% 49% 52% increase 59% SF-12, respectively. Unlikely others, plasma level TGF-β showed declining pattern after (from 765.0 1759.7 243.9 708.1 pg/mL, p = 0.07). No safety concerns observed. pilot suggests clinical potential managing focusing fatigue-related life. Further studies required confirm its large-scale randomized placebo-controlled trials future. been retrospectively registered identifier number KCT0008948 https://cris.nih.go.kr , 27/10/23.

Language: Английский

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The Role of the NRF2 Pathway in the Pathogenesis of Viral Respiratory Infections

Pathogens, Journal Year: 2023, Volume and Issue: 13(1), P. 39 - 39

Published: Dec. 31, 2023

In humans, acute and chronic respiratory infections caused by viruses are associated with considerable morbidity mortality. Respiratory infect airway epithelial cells induce oxidative stress, yet the exact pathogenesis remains unclear. Oxidative stress activates transcription factor NRF2, which plays a key role in alleviating redox-induced cellular injury. The transcriptional activation of NRF2 has been reported to affect both viral replication inflammation pathways. There is complex bidirectional crosstalk between virus pathway because directly or indirectly regulates expression, can reversely hamper spread across tissues. this review, we discuss regulation main viruses, including coronaviruses, influenza syncytial (RSV), rhinoviruses. We also summarize scientific evidence regarding effects known agonists that be utilized alter pathway.

Language: Английский

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The role of epithelial-mesenchymal transition in pulmonary fibrosis: lessons from idiopathic pulmonary fibrosis and COVID-19

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 13, 2024

Despite the tremendous advancements in knowledge of pathophysiology and clinical aspects SARS-CoV-2 infection, still many issues remain unanswered, especially long-term effects. Mounting evidence suggests that pulmonary fibrosis (PF) is one most severe complications associated with COVID-19. Therefore, understanding molecular mechanisms behind its development helpful to develop successful therapeutic strategies. Epithelial mesenchymal transition (EMT) cell specific variants endothelial (EndMT) mesothelial (MMT) are physio-pathologic cellular reprogramming processes induced by several infectious, inflammatory biomechanical stimuli. Cells undergoing EMT acquire invasive, profibrogenic proinflammatory activities secreting extracellular mediators. Their activity has been implicated pathogenesis PF a variety lung disorders, including idiopathic (IPF) Aim this article provide an updated survey mechanisms, emphasis on EMT-related processes, genesis IFP

Language: Английский

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Oxidative Stress Induced by Antivirals: Implications for Adverse Outcomes During Pregnancy and in Newborns

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1518 - 1518

Published: Dec. 12, 2024

Oxidative stress plays a critical role in various physiological and pathological processes, particularly during pregnancy, where it can significantly affect maternal fetal health. In the context of viral infections, such as those caused by Human Immunodeficiency Virus (HIV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), oxidative may exacerbate complications disrupting cellular function immune responses. Antiviral drugs, while essential managing these also contribute to stress, potentially impacting both mother developing fetus. Understanding mechanisms which antivirals examination pharmacokinetic changes pregnancy that influence drug metabolism is essential. Some research indicates antiretroviral drugs induce mitochondrial dysfunction other studies suggest their use generally safe. Therefore, concerns about long-term health effects persist. This review delves into complex interplay between antioxidant defenses, antiviral therapies, focusing on strategies mitigate potential damage. By addressing gaps our understanding, we highlight importance balancing efficacy with risks stress. Moreover, advocate for further develop safer, more effective therapeutic approaches pregnancy. dynamics optimizing outcomes fetus infections

Language: Английский

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