Frontiers in Microbiology,
Journal Year:
2021,
Volume and Issue:
12
Published: Sept. 30, 2021
Phage
bacteria
interactions
can
affect
structure,
dynamics,
and
function
of
microbial
communities.
In
the
context
biological
wastewater
treatment
(BWT),
presence
phages
alter
efficiency
process
influence
quality
treated
effluent.
The
active
role
in
BWT
has
been
demonstrated,
but
many
questions
remain
unanswered
regarding
diversity
these
engineered
environments,
dynamics
infection,
determination
bacterial
hosts,
impact
their
activity
full-scale
processes.
A
deeper
understanding
phage
ecology
lead
improvement
monitoring
control,
promote
higher
influent
quality,
potentiate
use
as
biocontrol
agents.
this
review,
we
highlight
suitable
methods
for
studying
adapted
from
other
research
fields,
provide
a
critical
overview
on
current
state
knowledge
effect
structure
communities,
gaps,
opportunities,
priority
to
be
addressed
future
research.
Antibiotics,
Journal Year:
2018,
Volume and Issue:
7(3), P. 66 - 66
Published: July 27, 2018
Despite
their
long
success
for
more
than
half
a
century,
antibiotics
are
currently
under
the
spotlight
due
to
emergence
of
multidrug-resistant
bacteria.
The
development
new
alternative
treatments
is
particular
interest
in
fight
against
bacterial
resistance.
Bacteriophages
(phages)
natural
killers
bacteria
and
an
excellent
tool
specificity
ecological
safety.
Here,
we
highlight
some
advantages
drawbacks
as
potential
therapeutic
agents.
Interestingly,
phages
not
only
attractive
from
clinical
point
view,
but
other
areas,
such
agriculture,
food
control,
or
industry,
also
areas
application.
Therefore,
propose
real
current
antibiotics.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(6), P. 1857 - 1857
Published: March 13, 2022
Bacterial
infectious
diseases
cause
serious
harm
to
human
health.
At
present,
antibiotics
are
the
main
drugs
used
in
treatment
of
bacterial
diseases,
but
abuse
has
led
rapid
increase
drug-resistant
bacteria
and
inability
effectively
control
infections.
Bacteriophages
a
kind
virus
that
infects
archaea,
adopting
as
their
hosts.
The
use
bacteriophages
antimicrobial
agents
is
an
alternative
antibiotics.
phage
therapy
(PT)
been
various
fields
provided
new
technology
for
addressing
caused
by
infections
humans,
animals,
plants.
PT
uses
infect
pathogenic
so
stop
treat
prevent
related
diseases.
However,
several
limitations,
due
narrow
host
range,
lysogenic
phenomenon,
lack
relevant
policies,
pharmacokinetic
data.
development
reasonable
strategies
overcome
these
limitations
essential
further
this
technology.
This
review
article
described
current
applications
summarizes
existing
solutions
limitations.
information
will
be
useful
clinicians,
people
working
agriculture
industry,
basic
researchers.
Vaccines,
Journal Year:
2023,
Volume and Issue:
11(4), P. 725 - 725
Published: March 24, 2023
Pathogens
found
in
food
are
believed
to
be
the
leading
cause
of
foodborne
illnesses;
and
they
considered
a
serious
problem
with
global
ramifications.
During
last
few
decades,
lot
attention
has
been
paid
determining
microorganisms
that
illnesses
developing
new
methods
identify
them.
Foodborne
pathogen
identification
technologies
have
evolved
rapidly
over
newer
focusing
on
immunoassays,
genome-wide
approaches,
biosensors,
mass
spectrometry
as
primary
identification.
Bacteriophages
(phages),
probiotics
prebiotics
were
known
ability
combat
bacterial
diseases
since
turn
20th
century.
A
focus
phage
use
was
development
medical
therapies;
however,
its
quickly
expanded
other
applications
biotechnology
industry.
similar
argument
can
made
regards
safety
industry,
directly
endanger
health
customers.
Recently,
bacteriophages,
most
likely
due
exhaustion
traditional
antibiotics.
Reviewing
variety
current
quick
techniques
is
purpose
this
study.
Using
these
techniques,
we
able
pathogenic
bacteria,
which
forms
basis
for
future
research
advances.
review
recent
studies
phages,
means
combating
significant
also
presented.
Furthermore,
discussed
advantages
using
phages
well
challenges
face,
especially
given
their
prevalent
application
safety.
Gut Pathogens,
Journal Year:
2017,
Volume and Issue:
9(1)
Published: Aug. 10, 2017
The
gut
microbiota
plays
an
essential
role
in
health
and
disease
of
humans.
Bacteriophages
are
the
most
abundant
members
virobiota
display
great
diversity.
Phages
can
translocate
through
mucosa
to
lymph
internal
organs
play
a
as
regulators
bacterial
population
gut.
Increasing
abundance
phages
may
reduce
colonization
by
bacteria.
Moreover,
have
immunomodulatory
immune
response
human
inflammatory
bowel
(IBD)
remains
unknown.
take
part
development
IBD,
but
there
also
data
suggesting
protective
patients
with
IBD.
Furthermore,
recent
suggest
that
mediate
beneficial
effects
fecal
transplantation
(FMT).
Therefore,
evidence
is
accumulating
highlight
immunomodulating
activity
phages.
Antibiotics,
Journal Year:
2018,
Volume and Issue:
7(1), P. 15 - 15
Published: Feb. 24, 2018
A
global
distribution
in
marine,
brackish,
and
freshwater
ecosystems,
combination
with
high
abundances
biomass,
make
vibrios
key
players
aquatic
environments,
as
well
important
pathogens
for
humans
marine
animals.
Incidents
of
Vibrio-associated
diseases
(vibriosis)
aquaculture
are
being
increasingly
reported
on
a
scale,
due
to
the
fast
growth
industry
over
past
few
decades
years.
The
administration
antibiotics
has
been
most
commonly
applied
therapy
used
control
vibriosis
outbreaks,
giving
rise
concerns
about
development
spreading
antibiotic-resistant
bacteria
environment.
Hence,
idea
using
lytic
bacteriophages
therapeutic
agents
against
bacterial
revived
during
last
Bacteriophage
constitutes
promising
alternative
not
only
treatment,
but
also
prevention
aquaculture.
However,
several
scientific
technological
challenges
still
need
further
investigation
before
reliable,
reproducible
treatments
commercial
potential
available
industry.
phage-based
alternatives
antibiotic
treatment
addressed
this
review.
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
151, P. 113122 - 113122
Published: May 17, 2022
The
Host-microbiome
interactions
that
exist
inside
the
gut
microbiota
operate
in
a
synergistic
and
abnormal
manner.
Additionally,
normal
homeostasis
functioning
of
are
frequently
disrupted
by
intervention
Multi-Drug
Resistant
(MDR)
pathogens.
CRISPR-Cas
(CRISPR-associated
protein
with
clustered
regularly
interspersed
short
palindromic
repeats)
recognized
as
prokaryotic
immune
system
has
emerged
an
effective
genome-editing
tool
to
edit
delete
specific
microbial
genes
for
expulsion
bacteria
through
bactericidal
action.
In
this
review,
we
demonstrate
many
systems
against
anti-microbial
resistance
multiple
pathogens,
which
infiltrate
gastrointestinal
tract.
Moreover,
discuss
advancement
development
phage-delivered
killing
MDR
pathogen.
We
also
combinatorial
approach
use
bacteriophage
delivery
gene
targeting
pathogenic
community
microbiome
resensitize
drug
sensitivity.
Finally,
engineered
phage
plausible
potential
option
improvement
efficacy
system.
Journal of Intensive Care,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Nov. 1, 2024
Abstract
The
increase
in
the
incidence
of
antibiotic-resistant
bacteria
poses
a
global
public
health
threat.
According
to
2019
WHO
report,
approximately
1.27
million
deaths
were
attributed
bacteria,
with
many
cases
linked
specific
bacterial
species,
such
as
drug-resistant
Pseudomonas
aeruginosa
and
Staphylococcus
aureus.
By
2050,
number
caused
by
these
is
predicted
surpass
that
cancer.
In
response
this
serious
situation,
phage
therapy,
an
alternative
antibiotic
treatment,
has
gained
attention.
Phage
therapy
involves
use
viruses
target
treat
infections.
This
method
proven
effective
multiple
clinical
cases,
particularly
for
patients
severe
infections
multidrug-resistant
bacteria.
For
example,
there
are
reports
systemic
Acinetobacter
who
recovered
following
administration
infected
panresistant
cured
therapy.
A
key
feature
its
high
specificity.
Phages
infect
only
eliminate
them.
However,
specificity
can
also
be
disadvantage,
careful
selection
appropriate
needed.
Additionally,
develop
resistance
phages,
potentially
reducing
treatment
effectiveness
over
time.
Efforts
underway
select,
combine,
improve
phages
address
challenges.
Belgium,
national
bank
been
established,
United
States,
University
California,
San
Diego,
founded
Innovative
Applications
Therapeutics
(IPATH),
marking
significant
progress
toward
application
country.
As
result,
emerging
component
personalized
medicine,
offering
new
option
against
important
life-saving
treatments
infections,
conjunction
antibiotics
could
enhance
therapeutic
outcomes.
Continued
research
development
provide
hope
more
future.
