Unraveling Immune-Related lncRNAs in Breast Cancer Molecular Subtypes DOI Creative Commons
Carolina Mathias, João C. D. Muzzi,

Bruna Borba Antunes

et al.

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 11

Published: May 31, 2021

Breast cancer (BRCA) is the most leading cause of worldwide. It a heterogeneous disease with at least five molecular subtypes including luminal A, B, basal-like, HER2-enriched, and normal-like. These are usually stratified according to their mRNA profile patterns; however, ncRNAs increasingly being used for this purpose. Among class, long non-coding RNAs (lncRNAs) molecules more than 200 nucleotides versatile regulatory roles; high tissue-specific expression profiles. The heterogeneity BRCA can also be reflected regarding tumor microenvironment immune cells composition, which directly impact patient’s prognosis therapy response. Using immunogenomics data from previous study, we propose here bioinformatics approach include lncRNAs complexity in subtype. RNA-seq Cancer Genome Atlas (TCGA) cohort was analyzed, signal-to-noise ratio metrics were applied create these subtype-specific signatures. Five immune-related signatures generated approximately ten specific lncRNAs, then functionally analyzed using GSEA enrichment survival analysis. We highlighted some each LINC01871 related response activation favorable overall basal-like samples; EBLN3P suppression progression MEG3, XXYLT1-AS2, LINC02613 HER2-enriched normal-like subtypes, respectively. In way, emphasize need know better role as regulators provide new perspectives diagnosis, therapeutical targets subtypes.

Language: Английский

Long Non-Coding RNA in the Pathogenesis of Cancers DOI Creative Commons
Yujing Chi, Di Wang,

Junpei Wang

et al.

Cells, Journal Year: 2019, Volume and Issue: 8(9), P. 1015 - 1015

Published: Sept. 1, 2019

The incidence and mortality rate of cancer has been quickly increasing in the past decades. At present, become leading cause death worldwide. Most cancers cannot be effectively diagnosed at early stage. Although there are multiple therapeutic treatments, including surgery, radiotherapy, chemotherapy, targeted drugs, their effectiveness is still limited. overall survival malignant low. It necessary to further study mechanisms for cancers, explore new biomarkers targets that more sensitive effective diagnosis, treatment, prognosis than traditional methods. Long non-coding RNAs (lncRNAs) a class RNA transcripts with length greater 200 nucleotides. Generally, lncRNAs not capable encoding proteins or peptides. LncRNAs exert diverse biological functions by regulating gene expressions transcriptional, translational, post-translational levels. In decade, it demonstrated dysregulated lncRNA profile widely involved pathogenesis many diseases, cancer, metabolic disorders, cardiovascular diseases. particular, have revealed play an important role tumor growth metastasis. Many shown potential diagnosis treatment cancers. This review aims briefly discuss latest findings regarding roles some certain lung, breast, liver, colorectal as well hematological malignancies neuroblastoma.

Language: Английский

Citations

708
Mechanisms of lncRNA/microRNA interactions in angiogenesis DOI
Zhuo Zhao, Wei Sun, Ziyuan Guo

et al.

Life Sciences, Journal Year: 2019, Volume and Issue: 254, P. 116900 - 116900

Published: Nov. 28, 2019

Language: Английский

Citations

241
Review: RNA-based diagnostic markers discovery and therapeutic targets development in cancer DOI
Hongbo Wang, Qinghai Meng, Jinjun Qian

et al.

Pharmacology & Therapeutics, Journal Year: 2022, Volume and Issue: 234, P. 108123 - 108123

Published: Feb. 1, 2022

Language: Английский

Citations

82
The complex role of MEG3: An emerging long non-coding RNA in breast cancer DOI Open Access
Md Sadique Hussain,

Abdullah A. Majami,

Ali Haider

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 251, P. 154850 - 154850

Published: Oct. 5, 2023

Language: Английский

Citations

46
lncRNA-microRNA axis in cancer drug resistance: particular focus on signaling pathways DOI
Raed Obaid Saleh, Mushtak T.S. Al-Ouqaili,

Eyhab Ali

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(2)

Published: Jan. 9, 2024

Language: Английский

Citations

19
Exosomal Long Non-Coding RNAs in Lung Diseases DOI Open Access
Christophe Poulet, Makon‐Sébastien Njock, Catherine Moermans

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(10), P. 3580 - 3580

Published: May 19, 2020

Within the non-coding genome landscape, long RNAs (lncRNAs) and their secretion within exosomes are a window that could further explain regulation, sustaining, spread of lung diseases. We present here compilation current knowledge on lncRNAs commonly found in Chronic Obstructive Pulmonary Disease (COPD), asthma, Idiopathic Fibrosis (IPF), or cancers. built interaction networks describing mechanisms action for COPD, IPF, as well private H19, MALAT1, MEG3, FENDRR, CDKN2B-AS1, TUG1, HOTAIR, GAS5 identified five signaling pathways targeted by these eight over diseases mentioned above. These were involved ten treatment resistances cancers, with HOTAIR being itself described seven resistances. Besides, them previously promising biomarkers diagnosis prognosis Additionally, we describe exosomal-based studies GAS5, UCA1, lnc-MMP2-2, GAPLINC, TBILA, AGAP2-AS1, SOX2-OT. This review concludes need additional lncRNA confirming potential biomarkers, involvement resistance to treatment, especially non-cancerous

Language: Английский

Citations

95
The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment DOI Creative Commons
Hossein Mozdarani,

Vahid Ezzatizadeh,

Roghayeh Rahbar Parvaneh

et al.

Journal of Translational Medicine, Journal Year: 2020, Volume and Issue: 18(1)

Published: April 3, 2020

Despite considering vast majority of the transcribed molecules as merely noise RNA in last decades, recent advances field molecular biology revealed mysterious role long non-coding RNAs (lncRNAs), a massive part functional non-protein-coding RNAs. As crucial lncRNA, HOX antisense intergenic (HOTAIR) has been shown to participate different processes normal cell development. Aberrant overexpression this lncRNA contributes breast cancer progression, through mechanisms. In review, we briefly discuss structure HOTAIR context genome and impact on human We subsequently summarize potential Ultimately, relationship with therapeutic approaches is discussed.

Language: Английский

Citations

94
Long non-coding RNAs in gastric cancer: New emerging biological functions and therapeutic implications DOI Creative Commons

Huidan Tan,

Shouyue Zhang, Jin Zhang

et al.

Theranostics, Journal Year: 2020, Volume and Issue: 10(19), P. 8880 - 8902

Published: Jan. 1, 2020

Gastric cancer (GC) is currently the fourth most common malignancy and third leading cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs), transcriptional products with more than 200 nucleotides, are not as well-characterized protein-coding RNAs. Accumulating evidence has recently revealed that maladjustments diverse lncRNAs may play key roles in multiple genetic epigenetic phenomena GC, affecting all aspects cellular homeostasis, such proliferation, migration, stemness. However, full extent their functionality remains to be clarified. Considering lack viable biomarkers therapeutic targets, future research should focused on unravelling intricate relationships between GC can translated from bench clinic. Here, we summarized state-of-the-art advances biological functions further discuss potential diagnostic roles. We aim shed light interrelationships respect applications. With better understanding these relationships, development will exploitable, promising new strategies developed for prevention treatment GC.

Language: Английский

Citations

81
Non-Coding RNAs in Cancer Diagnosis and Therapy: Focus on Lung Cancer DOI Open Access
Patricia Le, Giulia Romano,

Patrick Nana‐Sinkam

et al.

Cancers, Journal Year: 2021, Volume and Issue: 13(6), P. 1372 - 1372

Published: March 18, 2021

Over the last several decades, clinical evaluation and treatment of lung cancers have largely improved with classification genetic drivers disease, such as EGFR, ALK, ROS1. There are numerous regulatory factors that exert cellular control over key oncogenic pathways involved in cancers. In particular, non-coding RNAs (ncRNAs) a diversity roles they been shown to be inducing proliferation, suppressing apoptotic pathways, increasing metastatic potential cancer cells, acquiring drug resistance. The dysregulation various ncRNAs human has prompted preclinical studies examining therapeutic restoring and/or inhibiting these ncRNAs. Furthermore, demonstrate tissue-specific expression addition high stability within biological fluids. This makes them excellent candidates biomarkers. review aims discuss relevance pathology, diagnosis, therapy, focus on cancer.

Language: Английский

Citations

61
Non-Coding RNAs as Novel Regulators of Neuroinflammation in Alzheimer’s Disease DOI Creative Commons
Yuqing Liu, Xin Cheng, Hongli Li

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: June 2, 2022

Alzheimer’s disease (AD) is one of the most common causes dementia. Although significant breakthroughs have been made in understanding progression and pathogenesis AD, it remains a worldwide problem public health burden. Thus, more efficient diagnostic therapeutic strategies are urgently required. The latest research studies revealed that neuroinflammation crucial AD. Non-coding RNAs (ncRNAs), including long noncoding (lncRNAs), microRNAs (miRNAs), circular (circRNAs), PIWI-interacting (piRNAs), transfer RNA-derived small (tsRNAs), strongly associated with AD-induced neuroinflammation. Furthermore, several ongoing pre-clinical currently investigating ncRNA as biomarkers interventions to provide new perspectives for AD diagnosis treatment. In this review, role different types ncRNAs during summarized order improve our etiology aid translation basic into clinical practice.

Language: Английский

Citations

44