In light of breathing: environmental light is an important modulator of breathing with clinical implications DOI Creative Commons
Aaron A. Jones, Deanna M. Arble

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: July 13, 2023

In vertebrate animals, the automatic, rhythmic pattern of breathing is a highly regulated process that can be modulated by various behavioral and physiological factors such as metabolism, sleep–wake state, activity level, endocrine signaling. Environmental light influences many these modulating both indirectly organizing daily seasonal rhythms behavior directly through acute changes in neural While several observations from rodent human studies suggest environmental affects breathing, few have systematically evaluated underlying mechanisms clinical relevance on regulation respiratory behavior. Here, we provide new evidence discuss potential neurobiological which modulates breathing. We conclude should considered, bench to bedside, clinically relevant modulator health disease.

Language: Английский

The integrated brain network that controls respiration DOI Creative Commons
Friedrich Krohn, Manuele Novello, Ruben S. van der Giessen

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 8, 2023

Respiration is a brain function on which our lives essentially depend. Control of respiration ensures that the frequency and depth breathing adapt continuously to metabolic needs. In addition, respiratory control network has organize muscular synergies integrate ventilation with posture body movement. Finally, coupled cardiovascular emotion. Here, we argue can handle this all by integrating brainstem central pattern generator circuit in larger also comprises cerebellum. Although currently not generally recognized as center, cerebellum well known for its coordinating modulating role motor behavior, autonomic nervous system. review, discuss regions involved respiration, their anatomical functional interactions. We how sensory feedback result adaptation these mechanisms be compromised various neurological psychological disorders. demonstrate generators are part integrated regions.

Language: Английский

Citations

81
A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals DOI Creative Commons
Manuele Novello, Laurens W. J. Bosman, Chris I. De Zeeuw

et al.

The Cerebellum, Journal Year: 2022, Volume and Issue: 23(1), P. 210 - 239

Published: Dec. 28, 2022

Abstract The cerebellum is involved in many motor, autonomic and cognitive functions, new tasks that have a cerebellar contribution are discovered on regular basis. Simultaneously, our insight into the functional compartmentalization of has markedly improved. Additionally, studies output pathways seen renaissance due to development viral tracing techniques. To create an overview current state understanding efferents, we undertook systematic review all monosynaptic projections from brainstem diencephalon mammals. This revealed important cerebellum, motor nuclei, cerebral cortex, basal ganglia, predominantly di- or polysynaptic, rather than monosynaptic. Strikingly, most target areas receive input three showing convergence information at level. Overall, there appeared be large level agreement between different species as well use types neural tracers, making emerging picture solid one. Finally, discuss how this network affected by range diseases syndromes, with also non-cerebellar having impact areas.

Language: Английский

Citations

46
Brain-wide dynamics linking sensation to action during decision-making DOI Creative Commons
Andrei Khilkevich, Michael Lohse, Ryan Low

et al.

Nature, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Language: Английский

Citations

15
Cerebellar control of targeted tongue movements DOI Creative Commons
Lorenzo Bina,

Camilla Ciapponi,

Si‐yang Yu

et al.

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Abstract The cerebellum is critical for coordinating movements related to eating, drinking and swallowing, all of which require proper control the tongue. Cerebellar Purkinje cells can encode tongue movements, but it unclear how their simple spikes complex induce changes in shape that contribute goal‐directed movements. To study these relations, we recorded stimulated vermis hemispheres mice during spontaneous licking from a stationary or moving water spout. We found rhythmic with both spikes. Increased spike firing protrusion induces ipsiversive bending Unexpected target location trigger alter subsequent licks, adjusting trajectory. Furthermore, observed increased behavioural state at start end bouts. Using machine learning, confirmed alterations cell activity accompany licking, different often exerting heterogeneous encoding schemes. Our data highlight directional movement paramount cerebellar function modulation are complementary acquisition execution sensorimotor coordination. These results bring us closer understanding clinical implications disorders swallowing. image Key points When drinking, make directed towards source. fire rhythmically tune position source affects direction report also adjust right direction.

Language: Английский

Citations

1
Novel ADNP Syndrome Mice Reveal Dramatic Sex-Specific Peripheral Gene Expression With Brain Synaptic and Tau Pathologies DOI Creative Commons
Gidon Karmon, Shlomo Sragovich, Gal Hacohen-Kleiman

et al.

Biological Psychiatry, Journal Year: 2021, Volume and Issue: 92(1), P. 81 - 95

Published: Sept. 28, 2021

Language: Английский

Citations

47
A basal ganglia-like cortical–amygdalar–hypothalamic network mediates feeding behavior DOI Open Access
Marie Barbier,

Sandrine Chometton,

Arnaud Pautrat

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(27), P. 15967 - 15976

Published: June 22, 2020

Significance The network connecting the insular cortex, central nucleus of amygdala, and a caudal hypothalamic nuclear complex including parasubthalamic (PSTN) is interest due to its role in controlling feeding behavior. Here, we show that organization this similar basal ganglia network, implying both fit within simplified structural plan forebrain. Then, demonstrate PSTN modulates behavior response hedonic factors normally inducing “reward effect.” involved “non-feed” equivalent “non-reward” evaluation: “I don’t want consume food, recognized as good, because I am not conducive emotional or physiological state.”

Language: Английский

Citations

48
At the heart of the interoception network: Influence of the parasubthalamic nucleus on autonomic functions and motivated behaviors DOI

Tanvi Shah,

Jeffery L. Dunning, Candice Contet

et al.

Neuropharmacology, Journal Year: 2021, Volume and Issue: 204, P. 108906 - 108906

Published: Nov. 29, 2021

Language: Английский

Citations

25
Concerning neuromodulation as treatment of neurological and neuropsychiatric disorder: Insights gained from selective targeting of the subthalamic nucleus, para-subthalamic nucleus and zona incerta in rodents DOI Creative Commons
Alessia Ricci, E. Rubino, Gian Pietro Serra

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: 256, P. 110003 - 110003

Published: May 22, 2024

Neuromodulation such as deep brain stimulation (DBS) is advancing a clinical intervention in several neurological and neuropsychiatric disorders, including Parkinson's disease, dystonia, tremor, obsessive-compulsive disorder (OCD) for which DBS already applied to alleviate severely afflicted individuals of symptoms. Tourette syndrome drug addiction are two additional disorders trial or proposed treatment. However, some major remaining obstacles prevent this from reaching its full therapeutic potential. Side-effects have been reported, not all DBS-treated relieved their One target area electrodes the subthalamic nucleus (STN) plays important roles motor, affective associative functions, with impact on example movement, motivation, impulsivity, compulsivity, well both reward aversion. The multifunctionality STN complex. Decoding anatomical-functional organization could enhance strategic targeting human patients. located close proximity zona incerta (ZI) para-subthalamic (pSTN). Together, STN, pSTN ZI form highly heterogeneous clinically area. Rodent-based experimental studies, opto- chemogenetics viral-genetic tract tracings, provide unique insight into complex neuronal circuitries behavior high spatial temporal precision. This research field has advanced tremendously over past few years. Here, we an inclusive review current literature pre-clinical fields centered around laboratory mice rats; three enigmatic structures brought together context relevance treatment strategies. Specific emphasis placed methods manipulation behavioral impact.

Language: Английский

Citations

3
Inaugural Review Prize 2023: The exercise hyperpnoea dilemma: A 21st‐century perspective DOI Creative Commons
Joseph F. Welch,

Gordon S. Mitchell

Experimental Physiology, Journal Year: 2024, Volume and Issue: 109(8), P. 1217 - 1237

Published: March 29, 2024

During mild or moderate exercise, alveolar ventilation increases in direct proportion to metabolic rate, regulating arterial CO

Language: Английский

Citations

3
A subcortical feeding circuit linking an interoceptive node to jaw movement DOI Creative Commons
Christin Kosse, Jessica Ivanov, Zachary A. Knight

et al.

Nature, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Abstract The brain processes an array of stimuli, enabling the selection appropriate behavioural responses, but neural pathways linking interoceptive inputs to outputs for feeding are poorly understood 1–3 . Here we delineate a subcortical circuit in which brain-derived neurotrophic factor (BDNF)-expressing neurons ventromedial hypothalamus (VMH) directly connect motor centres, controlling food consumption and jaw movements. VMH BDNF neuron inhibition increases intake by gating sequences through projections premotor areas jaw. When is unavailable, elicits consummatory behaviours directed at inanimate objects such as wooden blocks, perimesencephalic trigeminal area (pMe5) evokes rhythmic activity these decreased during when proximity not consumed. Activity also increased obese animals after leptin treatment. receive monosynaptic from both agouti-related peptide (AgRP) proopiomelanocortin arcuate nucleus (Arc), constitutive activation blocks orexigenic effect AgRP activation. These data indicate Arc → pMe5 that senses energy state animal regulates state-dependent manner.

Language: Английский

Citations

3