In light of breathing: environmental light is an important modulator of breathing with clinical implications DOI Creative Commons
Aaron A. Jones, Deanna M. Arble

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: July 13, 2023

In vertebrate animals, the automatic, rhythmic pattern of breathing is a highly regulated process that can be modulated by various behavioral and physiological factors such as metabolism, sleep–wake state, activity level, endocrine signaling. Environmental light influences many these modulating both indirectly organizing daily seasonal rhythms behavior directly through acute changes in neural While several observations from rodent human studies suggest environmental affects breathing, few have systematically evaluated underlying mechanisms clinical relevance on regulation respiratory behavior. Here, we provide new evidence discuss potential neurobiological which modulates breathing. We conclude should considered, bench to bedside, clinically relevant modulator health disease.

Language: Английский

Whole‐brain neural connectivity to cholinergic neurons in the nucleus basalis of Meynert DOI

Zhao‐yi Chen,

Yao‐lian Yang,

Mai Suan Li

et al.

Journal of Neurochemistry, Journal Year: 2023, Volume and Issue: 166(2), P. 233 - 247

Published: June 23, 2023

Abstract The cholinergic neurons in the nucleus basalis of Meynert (NBM) are a key structure cognition, dysfunction which is associated with various neurological disorders, especially dementias. However, whole‐brain neural connectivity to NBM remains be further and comprehensively researched. Using virus‐based, specific, retrograde, anterograde tracing, we illustrated monosynaptic inputs axon projections choline acetyltransferase (ChAT)‐Cre transgenic mice. Our results showed that received mainly from caudate putamen posterior limb anterior commissure subcortex. Moreover, majority terminals were observed cortex mantle, including motor cortex, sensory visual cortex. Interestingly, although input putamen, interstitial commissure, central amygdaloid nucleus, sparsely sent projection innervate these areas. Furthermore, primary secondary somatosensory abundant but few outputs NBM. Taken together, our reveal detailed specific provide neuroanatomic foundation for studies explore important physiological functions neurons. image

Language: Английский

Citations

4
Posttraumatic Stress Disorder and Obstructive Sleep Apnea in Twins DOI Creative Commons
Amit Shah, Viola Vaccarino, Jack Goldberg

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(6), P. e2416352 - e2416352

Published: June 24, 2024

Importance Obstructive sleep apnea (OSA) is a common condition in older adult (aged >65 years) populations, but more mechanistic research needed to individualize treatments. Previous evidence has suggested an association between OSA and posttraumatic stress disorder (PTSD) limited by possible selection bias. High-quality on this with careful evaluation of confounders may yield important insight into both conditions improve treatment efforts. Objective To investigate the current PTSD symptoms diagnosis OSA. Design, Setting, Participants This cross-sectional study twin pairs discordant for PTSD, which allows adjustment familial factors, was conducted using in-laboratory polysomnography from March 20, 2017, June 3, 2019. The sample comprised male veteran twins recruited Vietnam Era Twin Registry. data analysis performed 11, 2022, January 30, 2023. Exposure Symptoms who served War. Diagnosis secondary exposure. Main Outcomes Measures assessed apnea-hypopnea index (AHI) (≥4% oxygen saturation criterion as measured events per hour) overnight polysomnography. were Checklist (PCL) structured clinical interview diagnosis. Results A total 181 (mean [SD] age, 68.4 [2.0] including 66 15 evaluated. In models examining PCL within adjusted body mass (BMI) other sociodemographic, cardiovascular, psychiatric risk factors (including depression), each 15-point increase associated 4.6 (95% CI, 0.1-9.1) events-per-hour higher AHI. Current 10.5 5.7-15.3) AHI sleep-hour. Comparable standardized estimates BMI SD (1.9 hour; 95% 0.5-3.3 found. Conclusions Relevance found sleep-disordered breathing. findings have public health implications also enhance understanding many that potentially affect pathophysiology.

Language: Английский

Citations

1
Whole-brain monosynaptic outputs and presynaptic inputs of GABAergic neurons in the vestibular nuclei complex of mice DOI Creative Commons
Xunbei Shi, Jing Wang, Feitian Li

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Aug. 26, 2022

GABAergic neurons in the vestibular nuclei (VN) participate multiple vital sensory processing allowing for maintenance and rehabilitation of functions. However, although important role GABA central system has been widely reported, underlying neural circuits between VN other brain functional regions remain elusive, which limits further study mechanism. Hence, it is necessary to elucidate connectivity based on outputs inputs VN. This employed a modified rabies virus retrograde tracing vector cre-dependent adeno-associated viruses (AAVs) anterograde vector, combined with transgenic VGAT-IRES-Cre mice, map whole brain. We found that 51 discrete received projections from brain, there were 77 upstream innervating These mainly located four regions, including medulla, pons, midbrain, cerebellum. Among them, established some especially regulating balance maintenance, emotion control, pain processing, sleep circadian rhythm regulation, fluid homeostasis. Therefore, this deepens comprehensive understanding whole-brain VN, providing neuroanatomical information research mechanism co-morbidities dysfunction.

Language: Английский

Citations

5
Role of the paraventricular nucleus of the hypothalamus in sleep–wake regulation DOI
Shan Jiang, Lu Chen, Zhi‐Li Huang

et al.

Brain Science Advances, Journal Year: 2022, Volume and Issue: 8(3), P. 197 - 209

Published: Sept. 1, 2022

The paraventricular nucleus of the hypothalamus (PVH) acts as a cohesive functional unit that regulates neuroendocrine and autonomic function, complex behavior, negative emotions after stress. However, how PVH integrates arousal with these biological functions has only recently been explored. Clinical reports, combined neurotoxic lesioning, immunochemistry, neuronal activity recordings, polysomnographic analyses genetically modified animals, have revealed is important for control wakefulness. Here, we review emerging anatomical neural mechanisms sleep–wake regulation in to support its essential role promotion maintenance

Language: Английский

Citations

5
In light of breathing: environmental light is an important modulator of breathing with clinical implications DOI Creative Commons
Aaron A. Jones, Deanna M. Arble

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: July 13, 2023

In vertebrate animals, the automatic, rhythmic pattern of breathing is a highly regulated process that can be modulated by various behavioral and physiological factors such as metabolism, sleep–wake state, activity level, endocrine signaling. Environmental light influences many these modulating both indirectly organizing daily seasonal rhythms behavior directly through acute changes in neural While several observations from rodent human studies suggest environmental affects breathing, few have systematically evaluated underlying mechanisms clinical relevance on regulation respiratory behavior. Here, we provide new evidence discuss potential neurobiological which modulates breathing. We conclude should considered, bench to bedside, clinically relevant modulator health disease.

Language: Английский

Citations

2