Impact of Nutrition on the Gut Microbiota: Implications for Parkinson’s Disease

Nutrition Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Parkinson's disease (PD) is a multifactorial neurodegenerative that characterized by the degeneration of dopaminergic neurons in substantia nigra pars compacta and anomalous accumulation α-synuclein aggregates into Lewy bodies neurites. Research suggests 2 distinct subtypes PD: brain-first subtype if pathology arises from brain then spreads to peripheral nervous system (PNS) body-first subtype, where pathological process begins PNS central system. This review primarily focuses on subtype. The influence gut microbiota development PD has been subject growing interest among researchers. It suggested inflammation may be closely associated with pathogenesis PD, therefore leading hypothesis modulation could play significant role this process. Nutrition can health alter risk progression altering inflammatory markers. provides an overview recent research correlates variations composition between patients healthy individuals impact certain nutrients dietary patterns, including Mediterranean diet, Western ketogenic diet. explores how these diets and, consequently, PD. Last, it examines fecal transplantation use prebiotics, probiotics, or synbiotics as potential therapeutic strategies balance microbiome, aiming reduce delay

Language: Английский

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GPX3 as a Novel and Potential Therapeutic Target in the Shared Molecular Mechanisms of Traumatic Brain Injury and Parkinson’s Disease

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1911 - 1928

Published: Feb. 1, 2025

Traumatic brain injury (TBI) is a prevalent neurological disorder associated with significant public health burdens and long-term risks, including neurodegenerative diseases such as Parkinson's disease (PD). Emerging evidence suggests strong link between moderate to severe TBI an elevated risk of PD, though the underlying mechanisms remain poorly understood. Common differentially expressed genes (DEGs) were identified in GEO datasets patients traumatic Further analyses, GO KEGG pathway enrichment, protein-protein interaction (PPI) network construction, hub gene identification, well miRNA transcription factor prediction drug candidate screening, conducted. Subsequently, expression was validated using additional TBI- PD-related Comparative Toxicogenomics Database (CTD). Finally, further mouse model induced by controlled cortical impact (CCI). Shared transcriptional signatures PD uncovered, highlighting overlapping molecular networks pathways. The glutathione peroxidase 3 (GPX3) emerged pivotal gene, its significantly altered both datasets. This study underscores critical role GPX3 intersection suggesting it novel potential therapeutic target, offering new insights into strategies.

Language: Английский

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Gut Microbial Metabolome and Dysbiosis in Neurodegenerative Diseases: Psychobiotics and Fecal Microbiota Transplantation as a Therapeutic Approach—A Comprehensive Narrative Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13294 - 13294

Published: Aug. 27, 2023

The comprehensive narrative review conducted in this study delves into the mechanisms of communication and action at molecular level human organism. addresses complex mechanism involved microbiota-gut-brain axis as well implications alterations microbial composition patients with neurodegenerative diseases. pathophysiology diseases neuronal loss or death is analyzed, main metabolites bidirectional through axis. In addition, interventions targeting gut microbiota restructuring fecal transplantation use psychobiotics-pre- pro-biotics-are evaluated an opportunity to reduce symptomatology associated neurodegeneration these pathologies. This provides valuable information facilitates a better understanding neurobiological be addressed treatment

Language: Английский

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Identification of necroptosis-related genes in Parkinson’s disease by integrated bioinformatics analysis and experimental validation

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: May 22, 2023

Background Parkinson’s disease (PD) is the second most common neurodegeneration worldwide. Necroptosis, which a new form of programmed cell death with high relationship inflammation, plays vital role in progression PD. However, key necroptosis related genes PD are not fully elucidated. Purpose Identification necroptosis-related Method The associated datasets and were downloaded from GEO Database GeneCards platform, respectively. DEGs obtained by gap analysis, followed cluster enrichment analysis WGCNA analysis. Moreover, generated PPI network their spearman correlation Immune infiltration was used for explore immune state brain accompanied expression levels these various types cells. Finally, gene validated an external dataset, blood samples patients toxin-induced model using real-time PCR Result Twelve including ASGR2, CCNA1, FGF10, FGF19, HJURP, NTF3, OIP5, RRM2, SLC22A1, SLC28A3, WNT1 WNT10B identified integrated bioinformatics dataset GSE7621. According to genes, RRM2 positively negatively correlated SLC22A1 respectively, while both OIF5 FGF19. As results M2 macrophage highest population analyzed samples. we found that 3 (CCNA1, OIP5 WNT10B) 9 (ASGR2, SLC28A3 WNT1) down- up- regulated GSE20141, All mRNA 12 obviously upregulated 6-OHDA-induced SH-SY5Y CCNA1 regulated, peripheral lymphocytes patients. Conclusion Necroptosis its inflammation play fundamental roles might be served as diagnostic markers therapeutic targets

Language: Английский

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The Contribution of Type 2 Diabetes to Parkinson’s Disease Aetiology

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4358 - 4358

Published: April 15, 2024

Type 2 diabetes (T2D) and Parkinson’s disease (PD) are chronic disorders that have a significant health impact on global scale. Epidemiological, preclinical, clinical research underpins the assumption insulin resistance inflammation contribute to overlapping aetiologies of T2D PD. This narrative review summarises recent evidence contribution initiation progression PD brain pathology. It also briefly discusses rationale potential alternative pharmacological interventions for treatment.

Language: Английский

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The Effect of Gut Microbiota-Targeted Interventions on Neuroinflammation and Motor Function in Parkinson’s Disease Animal Models—A Systematic Review

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(5), P. 3946 - 3974

Published: April 26, 2024

Gut microbiome-targeted interventions such as fecal transplant, prebiotics, probiotics, synbiotics, and antibiotic gut depletion are speculated to be of potential use in delaying the onset progression Parkinson’s disease by rebalancing microbiome context gut–brain axis. Our study aims organize recent findings regarding these animal models identify how they affect neuroinflammation motor outcomes. A systematic literature search was applied PubMed, Web Science, Embase, SCOPUS for non-dietary interventions. Studies that investigated gut-targeted using vivo murine PD follow dopaminergic cell loss, tests, neuroinflammatory markers outcomes were considered eligible. total 1335 studies identified databases, out which 29 found narrative systematization resulting data performed, effect direction represented. Quality assessment SYRCLE risk bias tool also performed. Out eligible studies, we a significant majority report intervention reduced loss (82.76%, 95% CI [64.23%, 94.15%]) produced induction model. Also, most reported reduction microglial (87.5%, [61.65%, 98.45%]) astrocytic activation (84,62%, [54.55%, 98.08%]) caused These results mirrored (96.4% [81.65%, 99.91%]) reporting an increase performance behavioral tests. limitation insufficient information assess specific causes bias. show can improve acute models. Further needed clarify if benefits transfer long-term pathogenesis disease, is not yet fully understood. The had no funding source, protocol registered PROSPERO database with ID number CRD42023461495.

Language: Английский

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Bidirectional regulation of levodopa-induced dyskinesia by a specific neural ensemble in globus pallidus external segment

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(6), P. 101566 - 101566

Published: May 16, 2024

Levodopa-induced dyskinesia (LID) is an intractable motor complication arising in Parkinson's disease with the progression of and chronic treatment levodopa. However, specific cell assemblies mediating have not been fully elucidated. Here, we utilize activity-dependent tool to identify three brain regions (globus pallidus external segment [GPe], parafascicular thalamic nucleus, subthalamic nucleus) that specifically contain dyskinesia-activated ensembles. An intensity-dependent hyperactivity subpopulation GPe (GPeTRAPed LID) observed during dyskinesia. Optogenetic inhibition GPeTRAPed LID significantly ameliorates LID, whereas reactivation evokes dyskinetic behavior levodopa-off state. Simultaneous chemogenetic another previously reported ensemble striatum reproduces induced by high-dose Finally, characterize as a subset prototypic neurons GPe. These findings provide theoretical foundations for precision medication modulation future.

Language: Английский

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Understanding what aspects of Parkinson’s disease matter most to patients and families

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 11, 2024

Language: Английский

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Molecular and Cellular Interactions in Pathogenesis of Sporadic Parkinson Disease

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(21), P. 13043 - 13043

Published: Oct. 27, 2022

An increasing number of the population all around world suffer from age-associated neurodegenerative diseases including Parkinson's disease (PD). This disorder presents different signs genetic, epigenetic and environmental origin, molecular, cellular intracellular dysfunction. At molecular level, α-synuclein (αSyn) was identified as principal molecule constituting Lewy bodies (LB). The gut microbiota participates in pathogenesis PD may contribute to loss dopaminergic neurons through mitochondrial most important pathogenetic link is an imbalance Ca2+ ions, which associated with redox cells increased generation reactive oxygen species (ROS). In this review, factors that cause these disorders their cause-and-effect relationships are considered. As a constituent factors, example organophosphates (OPs) also reviewed. role endothelial damage discussed, 'triple hit hypothesis' proposed modification Braak's dual one. absence effective therapies for diseases, more evidence emerging about positive impact nutritional structure healthy lifestyle on state blood vessels risk developing diseases.

Language: Английский

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Study of the gut microbiome in Egyptian patients with Parkinson’s Disease

BMC Microbiology, Journal Year: 2023, Volume and Issue: 23(1)

Published: July 22, 2023

Abstract Background Recently, an important relationship between Parkinson’s disease and the gut microbiota, through brain-gut axis interactions, has been established. Previous studies have declared that alterations in microbiota a great impact on pathogenesis clinical picture of (PD). The present study aimed to identify microbiome is likely related as well their possible relation phenotypes. Methods Thirty patients with disease, who presented Neurology Clinic Alexandria University Hospital were enrolled our study. A cross-matching control group 35 healthy subjects similar age sex included. Stool specimens taken from each. Quantitative SYBR Green Real-Time PCR was done for identification quantitation selected bacterial phyla, genera and/or species. Results There significant increase Bacteroides decrease Firmicutes / Bacteroidetes ratio Bifidobacteria PD patients. Although Prevotella decreased among relative control, difference not statistically significant. Comparing phenotypes group, Mixed phenotype had significantly higher , Tremors predominant lower ratio, both tremors postural instability gait disability (PIGD) . However, there no these Furthermore, when comparing non-tremors phenotypes; Lactobacilli showed Conclusions current evidence changes compared controls. These observations may highlight importance specific can be targeted treatment disease.

Language: Английский

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