Specific retinal neurons regulate context-dependent defensive responses to visual threat DOI Creative Commons

Tracy Lee,

Hannah Weinberg‐Wolf, Thomas E. Zapadka

et al.

PNAS Nexus, Journal Year: 2024, Volume and Issue: 3(10)

Published: Sept. 24, 2024

Abstract While encountering a visual threat, an animal assesses multiple factors to choose appropriate defensive strategy. For example, when rodent detects looming aerial predator, its behavioral response can be influenced by specific environmental context, such as the availability of shelter. Indeed, rodents typically escape from stimulus shelter is present; otherwise, they freeze. Here we report that context-dependent responses initiated at earliest stage system distinct types retinal ganglion cells (RGCs), retina's output neurons. Using genetically defined cell ablation in mature mice, discovered some RGC were necessary for either escaping (alpha RGCs) or freezing (intrinsically photosensitive but not both behaviors; whereas other required behavior (direction-selective RGCs preferring vertical motion). Altogether, our results suggest regulate elicited same threatening depending on contextual signals environment. These findings emphasize unique contribution early pathways evolutionally conserved reactions.

Language: Английский

Mating proximity blinds threat perception DOI Creative Commons
Laurie Cazalé-Debat, Lisa Scheunemann,

Megan Day

et al.

Nature, Journal Year: 2024, Volume and Issue: 634(8034), P. 635 - 643

Published: Aug. 28, 2024

Abstract Romantic engagement can bias sensory perception. This ‘love blindness’ reflects a common behavioural principle across organisms: favouring pursuit of coveted reward over potential risks 1 . In the case animal courtship, such biases may support reproductive success but also expose individuals to danger, as predation 2,3 However, how neural networks balance trade-off between risk and is unknown. Here we discover dopamine-governed filter mechanism in male Drosophila that reduces threat perception courtship progresses. We show during early stages, threat-activated visual neurons inhibit central nodes via specific serotonergic neurons. inhibition prompts flies abort when they see imminent danger. advance process, dopaminergic system responses, shifting from survival mating. By recording activity males approach mating, demonstrate progress registered levels ramping up. dopamine signalling inhibits detection pathway Dop2R receptors, allowing focus on are close copulation. Thus, based perceived goal proximity, prioritize competing behaviours.

Language: Английский

Citations

4
The visuomotor transformations underlying target-directed behavior DOI Creative Commons
Peixiong Zhao, Yuxin Tong,

Ivan P. Lazarte

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(13)

Published: March 24, 2025

The visual system can process diverse stimuli and make the decision to execute appropriate behaviors, but it remains unclear where how this transformation takes place. Innate visually evoked behaviors such as hunting, freezing, escape are thought be deeply conserved, have been described in a range of species from insects humans. We found that zebrafish larvae would respond predator-like with immobility bradycardia, both hallmarks head-fixed behavioral paradigm. then imaged while responded different systematically identified driven neurons behaviorally correlated sensorimotor neurons. Our analyses indicate within optic tectum, broadly tuned sensory functionally which specifically during one behavior, indicating contains suitable information for transformation. also four other areas downstream these specific segregation pathways continues areas. While our findings shed light on may integrate inputs, further investigation will required determine regions interact behave is made.

Language: Английский

Citations

0
Characterization of Neural Network Connectivity and Modularity of Pigeon Nidopallium Caudolaterale During Target Detection DOI Creative Commons
Zhizhong Wang, Wang Hu, Juncai Zhu

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(4), P. 609 - 609

Published: Feb. 19, 2025

Accurate target detection in natural environments is an important function of the visual systems vertebrates and has a direct impact on animal survival environmental adaptation. Existing studies have shown that mammalian prefrontal cortex plays role detection. However, mechanisms brain regions similar to other species, such as avian nidopallium caudolaterale, not been well studied. Here, we selected pigeons, known for their excellent ability, model studied dynamic changes caudolaterale neural network features while they performed task maze. The results showed average node degree increased significantly during process modularity decreased significantly. This indicated functional connectivity pigeon brains was enhanced execution, frequency interactions increased, shifted from distributed processing more efficient integrated processing. decoding based combination both accuracy corresponding higher. Taken together, our confirmed above properties encoding information. We provided evidence support view NCL critical tasks studying key its provides powerful tool revealing state brain.

Language: Английский

Citations

0
Catch me if you can: free-living mice show a highly flexible dodging behaviour suggestive of intentional tactical deception DOI Creative Commons
Raffaele d’Isa, Michael H. Parsons, M. Chrzanowski

et al.

Royal Society Open Science, Journal Year: 2024, Volume and Issue: 11(7)

Published: July 1, 2024

Intentional tactical deception, the employment of a tactic to intentionally deceive another animal, is complex behaviour based on higher-order cognition, that has rarely been documented outside primates and corvids. New laboratory-to-field assays, however, provide opportunity investigate such among free-living mice. In present study, we placed laboratory-style test chambers with single entrance near forest Warsaw, where observed social interactions two territorial murids, black-striped yellow-necked mice, under food competition for seven months. Notably, interactions, video-recorded 21 instances deceptive pursuer evasion. most obvious cases, an individual inside chamber, avoid incoming mouse, hid by chamber opening (the only means enter or exit), paused until entered passed by, then exploited distraction back-turned fleeing through in direction opposite one came from. This dodging first evidence suggestive intentional deception As such, this may be interest not rodent psychology but also, more generally, fields non-human intentionality theory mind.

Language: Английский

Citations

2
Cross-modal enhancement of defensive behavior via parabigemino-collicular projections DOI
Bo Peng, Junxiang Huang, Zhong Li

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(16), P. 3616 - 3631.e5

Published: July 16, 2024

Language: Английский

Citations

2
GABAergic Retinal Ganglion Cells Projecting to the Superior Colliculus Mediate the Looming-Evoked Flight Response DOI
Man Yuan,

Gao Tan,

Danrui Cai

et al.

Neuroscience Bulletin, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Language: Английский

Citations

2
A Non-canonical Excitatory PV RGC–PV SC Visual Pathway for Mediating the Looming-evoked Innate Defensive Response DOI
Man Yuan, Sen Jin,

Gao Tan

et al.

Neuroscience Bulletin, Journal Year: 2023, Volume and Issue: 40(3), P. 310 - 324

Published: June 11, 2023

Language: Английский

Citations

5
The visuomotor transformations underlying defensive behaviors and hunting DOI Open Access
Peixiong Zhao, Yuxin Tong,

Ivan P. Lazarte

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Summary The visual system can process diverse stimuli and make the decision to execute appropriate behaviors, but it remains unclear where how this transformation takes place. We imaged zebrafish while larvae responded with hunting, freezing, escape systematically identified visually driven neurons behaviorally correlated sensorimotor neurons. found that broadly tuned sensory are functionally connected respond specifically during one behavior, occurs in optic tectum. also four other areas downstream of tectum, these specific for indicating once behave has been made segregation pathways continues later areas. Our findings suggest tectum receives information is responsible selecting a single behavioral outcome, which then relayed

Language: Английский

Citations

1
Un-EVIMO: Unsupervised Event-Based Independent Motion Segmentation DOI
Ziyun Wang, Jinyuan Guo, Kostas Daniilidis

et al.

Lecture notes in computer science, Journal Year: 2024, Volume and Issue: unknown, P. 228 - 245

Published: Oct. 28, 2024

Language: Английский

Citations

1
Interpeduncular GABAergic neuron function controls threat processing and innate defensive adaptive learning DOI
Susanna Molas, Elora Williams,

Leshia Snively

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Abstract The selection of appropriate defensive behaviors in the face potential threat is fundamental to survival. However, after repeated exposures threatening stimuli that did not signal real danger, an animal must learn adjust and optimize behaviors. Despite extensive research on innate processing, little known how individuals change their when presented with recurrent without evidence a risk. Insight into this process critical as its dysregulation may contribute neuropsychiatric conditions, such anxiety disorders. Here, we used visual looming stimulus (VLS) paradigm mice investigate processing adaptive learning. Repeated exposure VLS over consecutive sessions reduced immediate freezing responses time spent inside sheltered area upon events, leading increase foraging Fiber photometry recordings optogenetic manipulations revealed learning associated recruitment midbrain interpeduncular nucleus (IPN), structure fear anxiety-related Functional circuit-mapping identified role for select IPN projections laterodorsal tegmental gating Finally, uncovered subpopulation neurons express neuropeptide somatostatin encode safety- avoidance signals response VLS. These results identify behavioral signatures circuit regulates essential features processing.

Language: Английский

Citations

0