Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: June 3, 2020

Oxidative stress is associated with many acute and chronic inflammatory diseases, yet limited treatment currently available clinically. The development of enzyme-mimicking nanomaterials (nanozymes) good reactive oxygen species (ROS) scavenging ability biocompatibility a promising way for the ROS-related inflammation. Herein we report simple efficient one-step ultrasmall Cu

Language: Английский

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Biomedicine Meets Fenton Chemistry

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(4), P. 1981 - 2019

Published: Jan. 25, 2021

Since the first connection between Fenton chemistry and biomedicine, numerous studies have been presented in this field. Comprehensive presentation of guidance from a summary its representative applications cancer therapy would help us understand promote further development This comprehensive review supplies basic information regarding chemistry, including reactions Fenton-like reactions. Subsequently, current progress is discussed, with some corresponding examples presented. Furthermore, strategies for optimizing performance chemodynamic guided by are highlighted. Most importantly, future perspectives on combination biomedicine or wider range catalytic approaches We hope that will attract positive attention materials science, fields tighten their connections.

Language: Английский

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Nanocatalytic Medicine

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(39)

Published: July 22, 2019

Abstract Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such nanozymes, photocatalysts, electrocatalysts, have been applied vivo to initiate catalytic reactions modulate biological microenvironments for generating therapeutic effects. The rapid growth biomedical applications nanocatalysts has led the concept “nanocatalytic medicine,” which is expected promote further advance a subdiscipline nanomedicine. high efficiency selectivity catalysis that chemists strived achieve past century can be ingeniously translated into efficacy mitigated side effects theranostics using medicine” steer optimized outcomes. Here, rationale behind construction nanocatalytic eludicated based on essential reaction factors (catalysts, energy input, reactant). Recent this burgeoning field then comprehensively presented mechanisms nanosystems conferred theranostic functions discussed detail. It believed an emerging modality will play more important role

Language: Английский

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GSH‐Depleted PtCu₃ Nanocages for Chemodynamic‐ Enhanced Sonodynamic Cancer Therapy

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 30(4)

Published: Nov. 13, 2019

Abstract The ultrahigh concentration of glutathione (GSH) inside tumors destroys reactive oxygen species (ROS)‐based therapy, improving the outcome chemodynamic therapy (CDT)‐enhanced sonodynamic (SDT) by depleting GSH is full great challenge. Herein, PtCu 3 nanocages are first reported as acting a sonosensitizer with highly efficient ROS generation under ultrasound irradiation. In addition, can act horseradish peroxidase‐like nanozymes, catalyzing decomposition H 2 O into • OH acidic conditions for CDT. Surprisingly, another kind nanozyme, mimicking peroxidase (GSH‐Px), which plays an important role in accelerating depletion oxidizing molecules, further weakening capacity tumor cells scavenging GSH. Both vitro and vivo studies demonstrate that perform well reducing level CDT‐enhanced SDT. Moreover, utilizing high absorption near‐infrared region strong X‐ray attenuation ability, able to conduct photoacoustic/computed tomography dual‐modal imaging‐guided combined cancer therapy. It worth mentioning cause minimal toxicity normal tissues at therapeutic doses. This work highlights use effective SDT via depletion.

Language: Английский

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A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 13(1)

Published: July 9, 2021

Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress nanozymes has been made with deep investigation of diverse and rapid development related nanotechnologies. As promising alternatives for natural enzymes, have broadened way toward clinical medicine, food safety, environmental monitoring, chemical production. The past decade witnessed metal- metal oxide-based owing their remarkable physicochemical properties parallel low cost, high stability, easy storage. It is widely known that study catalytic activities mechanism sheds significant influence on applications nanozymes. This review digs into characteristics intrinsic nanozymes, especially emphasizing recent biological analysis, relieving inflammation, antibacterial, cancer therapy. We also conclude present challenges provide insights future constituted oxide nanomaterials.

Language: Английский

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Inorganic nanomaterials with rapid clearance for biomedical applications

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8669 - 8742

Published: Jan. 1, 2021

Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) can provide desirable functionality drug delivery, diagnostics, imaging, therapy) considerable potential for application in the field of biomedicine. However, toxicity be caused by long-term, non-specific accumulation these inorganic healthy tissues, preventing their large-scale clinical utilization. Over past several decades, emergence biodegradable and clearable has offered to prevent such long-term toxicity. In addition, a comprehensive understanding design metabolic pathways within body is essential enabling expansion theranostic applications various diseases advancing trials. Thus, it critical importance develop biomedical applications. This review systematically summarizes recent progress nanomaterials, particularly cancer theranostics other disease therapies. The future prospects opportunities this rapidly growing are also discussed. We believe timely will stimulate guide additional in-depth studies area nanomedicine, as rapid vivo clearance degradation likely prerequisite translation with unique functionality.

Language: Английский

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Design of therapeutic biomaterials to control inflammation

Nature Reviews Materials, Journal Year: 2022, Volume and Issue: 7(7), P. 557 - 574

Published: Feb. 28, 2022

Language: Английский

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Nanozymes-recent development and biomedical applications

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Feb. 22, 2022

Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed the catalytic reactions natural enzymes. In field biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic be regulated by multiple factors, such as chemical state metal ion, pH, hydrogen peroxide (H2O2), glutathione (GSH) level, presenting great promise for biomedical applications. Over past decade, multi-functional have been developed various To promote understandings development novel multifunctional nanozymes, we herein provide comprehensive review applications in field. Nanozymes versatile enzyme-like properties briefly overviewed, mechanism application discussed future research. Finally, underlying challenges prospects frontier this review.

Language: Английский

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Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 142(3), P. 1636 - 1644

Published: Dec. 27, 2019

Recent advances in nanomedicine have facilitated the development of potent nanomaterials with intrinsic enzyme-like activities (nanozymes) for cancer therapy. However, it remains a great challenge to fabricate smart nanozymes that precisely perform enzymatic activity tumor microenvironment without inducing off-target toxicity surrounding normal tissues. Herein, we report on designed fabrication biodegradation-medicated activity-tunable molybdenum oxide nanourchins (MoO3-x NUs), which selectively therapeutic via cascade catalytic reactions, while keeping tissues unharmed due their responsive biodegradation physiological environment. Specifically, MoO3-x NUs first induce catalase (CAT)-like reactivity decompose hydrogen peroxide (H2O2) microenvironment, producing considerable amount O2 subsequent oxidase (OXD)-like NUs; substantial cytotoxic superoxide radical (·O2-) is thus generated cell apoptosis. Interestingly, once exposed neutral blood or tissues, rapidly lose pH-responsive and are excreted urine, ultimately ensuring safety. The current study demonstrates proof concept vivo tumor-specific therapy minimal toxicity.

Language: Английский

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An Enzyme‐Mimicking Single‐Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(13), P. 5108 - 5115

Published: Jan. 21, 2020

Abstract Sepsis, characterized by immoderate production of multiple reactive oxygen and nitrogen species (RONS), causes high morbidity mortality. Despite progress made with nanozymes, efficient antioxidant therapy to eliminate these RONS remains challenging, owing largely the specificity low activity exploited nanozymes. Herein, an enzyme‐mimicking single‐atom catalyst, Co/PMCS, features atomically dispersed coordinatively unsaturated active Co‐porphyrin centers, which can rapidly obliterate alleviate sepsis. Co/PMCS O 2 .− H mimicking superoxide dismutase, catalase, glutathione peroxidase, while removing . OH via oxidative‐reduction cycle, markedly higher than It also scavenge NO through formation a nitrosyl–metal complex. Eventually, it reduce proinflammatory cytokine levels, protect organs from damage, confer distinct survival advantage infected sepsis mice.

Language: Английский

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