The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food Allergy

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 92 - 92

Published: Dec. 27, 2023

Food allergy (FA) is a growing public health concern, with an increasing prevalence in Western countries. Increasing evidence suggests that the balance of human gut microbiota and integrity our intestinal barrier may play roles development FA. Environmental factors, including industrialization consumption highly processed food, can contribute to altering barrier, susceptibility allergic sensitization. Compositional functional alterations microbiome have also been associated In addition, increased permeability allows translocation allergenic molecules, triggering Th2 immune responses. Preclinical clinical studies highlighted potential probiotics, prebiotics, postbiotics prevention treatment FA through enhancing function promoting restoration healthy microbiota. Finally, fecal transplantation (FMT) now being explored as promising therapeutic strategy prevent both experimental studies. this review article, we aim explore complex interplay between FA, well depict strategies.

Language: Английский

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Probiotics in Infancy and Childhood for Food Allergy Prevention and Treatment

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 297 - 297

Published: Jan. 18, 2024

Food allergy represents a failure of oral tolerance mechanisms to dietary antigens. Over the past few years, food allergies have become growing public health problem worldwide. Gut microbiota is believed significant impact on antigens and in initiation maintenance allergies. Therefore, probiotics also been proposed this field as possible strategy for modulating both gut immune system. In recent results from preclinical clinical studies suggest promising role prevention treatment. However, future are needed better understand action design comparable study protocols using specific probiotic strains, defined doses exposure times, longer follow-up periods.

Language: Английский

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The Most Promising Next-Generation Probiotic Candidates—Impact on Human Health and Potential Application in Food Technology

Fermentation, Journal Year: 2024, Volume and Issue: 10(9), P. 444 - 444

Published: Aug. 23, 2024

A substantial body of research indicates that the gut microbiota exerts a profound influence on host health. The purpose this work was to characterize selected, most promising, well-known next-generation probiotics (NGPs) and review potential applications bacteria in food technology. isolation with significant health benefits has led emergence NGPs. In contrast traditional probiotics, these originate directly from microbiota, thereby ensuring their optimal adaptation intestinal ecosystem. NGPs exert effects organism through variety mechanisms, including synthesis bioactive compounds, modulation metabolism substances provided by host. Several bacterial species have been identified as candidates for NGPs, Akkermansia muciniphila, Faecalibacterium prausnitzii, Bacteroides thetaiotaomicron, Christensenella minuta, many others. These demonstrated capacity beneficial effects, reduction obesity, type 2 diabetes, metabolic disorders, even cancers. greatest limitation commercialization is lack oxygen tolerance, which presents challenges not only but also application food. approach appears be microencapsulation. Further required establish safety NGP supplementation protect them environmental conditions.

Language: Английский

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Intestinal permeability, food antigens and the microbiome: a multifaceted perspective

Frontiers in Allergy, Journal Year: 2025, Volume and Issue: 5

Published: Jan. 9, 2025

The gut barrier encompasses several interactive, physical, and functional components, such as the microbiota, mucus layer, epithelial layer mucosal immunity. All these contribute to homeostasis in a well-regulated manner. Nevertheless, this frail balance might be disrupted for instance by westernized dietary habits, infections, pollution or exposure antibiotics, thus diminishing protective immunity leading onset of chronic diseases. Several gaps knowledge still exist regards multi-level interaction. In review we aim summarize current evidence linking food antigens, microbiota permeability interference diverse disease conditions celiac (CeD), non-celiac wheat sensitivity (NCWS), allergies (FA), eosinophilic gastrointestinal disorder (EOGID) irritable bowel syndrome (IBS). Specific elimination diets are recommended CeD, NCWS, FA some cases EOGID. Undoubtfully, each is very different quite unique, albeit antigens/compounds, intestinal specific signatures orchestrate immune response decide clinical outcomes all them.

Language: Английский

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Silver carp by-product hydrolysate: A promising mucin substitute for stimulating Akkermansia muciniphila growth and metabolic activity

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106310 - 106310

Published: March 1, 2025

Language: Английский

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Update on In Vitro Diagnostic Tools and Treatments for Food Allergies

Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3744 - 3744

Published: Aug. 26, 2023

Food allergy (FA) is an adverse immunological reaction to a specific food that can trigger wide range of symptoms from mild life-threatening. This caused by different mechanisms, such as IgE-mediated, non-IgE-mediated and mixed IgE-mediated reactions. Its epidemiology has had significant increase in the last decade, more so developed countries. It estimated approximately 2 10% world’s population FA this number appears be increasing also affecting children. The diagnosis complex requires combination tests establish accurate diagnosis. However, treatment based on avoiding intake allergenic food, thus being very difficult at times controlling case accidental exposure. Currently, there are other immunomodulatory treatments allergen immunotherapy or innovative induce tolerance response. important mention research field ongoing clinical trials underway assess safety efficacy these approaches, new pathways used target promote In review, we describe vitro diagnostic tools therapeutic show latest advances management. We conclude although have been made improve therapies for FA, urgent need standardize both that, their totality, they help management FA.

Language: Английский

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Single exposure of food-derived polyethylene and polystyrene microplastics profoundly affects gut microbiome in an in vitro colon model

Environment International, Journal Year: 2024, Volume and Issue: 190, P. 108884 - 108884

Published: July 10, 2024

Microplastics (MPs) are widespread contaminants highly persistent in the environment and present matrices to which humans extensively exposed, including food beverages. MP ingestion occurs adults children is becoming an emerging public health issue. The gastrointestinal system most exposed contamination, can alter its physiology starting from changes microbiome. This study investigates by omic approach impact of a single intake mixture polyethylene (PE) polystyrene (PS) MPs on ecology metabolic activity colon microbiota healthy volunteers, vitro intestinal model. PE PS were pooled together homogeneous mix, digested with INFOGEST system, fermented MICODE (multi-unit model) at loads that literature correspond possible food-derived meal. Results demonstrated induced opportunistic bacteria overgrowth (Enterobacteriaceae, Desulfovibrio spp., Clostridium group I Atopobium - Collinsella group) contextual reduction abundances all beneficial taxa analyzed, sole exception Lactobacillales. shift was consistent recorded bacterial activity.

Language: Английский

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A Mixture of Four Probiotic Strains (Probiatop®) Mitigates Food Allergy to Ovalbumin in Mice

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Language: Английский

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Dietary fibers affecting gastrointestinal immunity

Trends in Immunology, Journal Year: 2023, Volume and Issue: 44(11), P. 868 - 870

Published: Oct. 6, 2023

Language: Английский

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Studies on the Probiotic, Adhesion and Induction Properties of Artisanal Lactic Acid Bacteria: To Customize a Gastrointestinal Niche to Trigger Anti-Obesity Functions

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

Aims: The primary goals of this work are to explore the potential probiotic LAB's mucin/mucus layer thickening properties and identify anti-obesity candidate strains that improve appropriate habitat for use with Akkermansia group population in future. Methods Results: The HT-29 cell binding, antimicrobial properties, adhesion layer, growth presence mucin, stability during in vitrogastrointestinal (GI) conditions, biofilm formation, thickness increment abilities were all assessed artisanal LAB strains. Sixteen out 40 chosen further analysis based on their ability withstand GI conditions. Thirteen maintained vitality simulated intestinal fluid, whereas majority displayed high viability gastric juice simulation. Furthermore, 35.2-65.4% those 16 bacteria adhered mucin layer. Besides, different lactate levels produced, Streptococcus thermophilusUIN9 exhibited highest development. Also, a 50 mM concentration had been injected originally, Lacticaseibacillus casei NRRL-B 441 maximum amount (321.6 µg/mL). Conclusions: Two isolates olive from Lactiplantibacillus plantarum as prototype candidates; these did not consume sugars. Significance Impact Study: Probiotic attachment colonic mucosa its stimulate cells secrete mucus critical mechanisms may support development Akkermansia.

Language: Английский

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