Adverse Outcome Pathways (AOPs) Oriented Approach to Assess In Vitro Hazard of Silica and Lignin Nanomaterials Derived from Biomass Residues DOI Creative Commons
Rossella Bengalli, Maurizio Gualtieri,

Mariana Ornelas

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(7), P. 549 - 549

Published: April 4, 2025

Bio-based nanomaterials (B-NMs), such as silica oxide (SiO2)- and lignin (Lig)- based nanoparticles (NPs) derived from biomass waste, have gained attention in the last few years view of promoting sustainability principles several applications. However, scarce data are available about their safety. Thus, a hazard-testing strategy was designed considering reference safe-and-sustainable-by-design (SSbD) framework for chemicals materials, prioritizing use new approach methodologies (NAMs), vitro adverse outcome pathways (AOPs) approaches, generating potential hazard B-NMs. Literature research performed to identify outcomes (AOs) related selected All AOPs investigated shared at least oxidative stress, inflammation cytotoxicity key events (KEs) that were lung immune cells. The tested B-NMs resulted either non-toxic or moderately toxic towards human cells, validating biocompatibility when compared NMs similar composition, but not bio-origin. should be given possible AOs deriving after specific functionalization Considering lack knowledge this field, studies represent step forward state art safety assessment

Language: Английский

Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation DOI Creative Commons
Mohammad Chehelgerdi, Matin Chehelgerdi, Omer Qutaiba B. Allela

et al.

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Oct. 9, 2023

Abstract The use of nanotechnology has the potential to revolutionize detection and treatment cancer. Developments in protein engineering materials science have led emergence new nanoscale targeting techniques, which offer renewed hope for cancer patients. While several nanocarriers medicinal purposes been approved human trials, only a few authorized clinical cells. In this review, we analyze some formulations discuss challenges translating findings from lab clinic. This study highlights various compounds that can be used selective tumor inherent difficulties therapy. Nanotechnology provides promising platform improving future, but further research is needed overcome current limitations translation. Graphical

Language: Английский

Citations

434
Silica nanoparticles are novel aqueous additive mitigating heavy metals toxicity and improving the health of African catfish, Clarias gariepinus DOI
Heba H. Mahboub, Khalid Shahin,

Shereen Mahmoud

et al.

Aquatic Toxicology, Journal Year: 2022, Volume and Issue: 249, P. 106238 - 106238

Published: July 14, 2022

Language: Английский

Citations

41
Nanoparticle-Based Approaches for Treatment of Hematological Malignancies: a Comprehensive Review DOI
Umme Hani, B.H. Jaswanth Gowda, Nazima Haider

et al.

AAPS PharmSciTech, Journal Year: 2023, Volume and Issue: 24(8)

Published: Nov. 16, 2023

Language: Английский

Citations

38
Comprehensive review of polymeric nanocomposite membranes application for water treatment DOI Creative Commons
Umme Hani

Alexandria Engineering Journal, Journal Year: 2023, Volume and Issue: 72, P. 307 - 321

Published: April 15, 2023

Contamination of water has been reported to be a serious environmental challenge. Therefore, development novel technologies tackle this issue is fundamental importance from an perspective. Nanocomposite membranes, which are utilized improve the separation properties standard polymeric have recently remarkable attention for purifying different contaminants including microorganisms, chemical compounds, dyes, etc. The principal aim review investigation present current advancements towards application nanocomposite membranes in treatment. Important pollutants sources presented and their detrimental impacts discussed detail. Furthermore, utilization industrial activities such as desalination, nanoparticle separation, dye removal, antibacterial applications, inorganic natural organic materials removal paper. This also organized recommend better insights about mechanisms membrane major existed sources, can provide opportunities global population achieve sustainable clean water.

Language: Английский

Citations

36
Stöber method and its nuances over the years DOI
Alan dos Santos da Silva, João Henrique Zimnoch dos Santos

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 314, P. 102888 - 102888

Published: March 28, 2023

Language: Английский

Citations

35
Nanoparticle Synthesis and Their Integration into Polymer-Based Fibers for Biomedical Applications DOI Creative Commons
Joana Domingues, Catarina S. Miranda, Natália C. Homem

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(7), P. 1862 - 1862

Published: June 29, 2023

The potential of nanoparticles as effective drug delivery systems combined with the versatility fibers has led to development new and improved strategies help in diagnosis treatment diseases. Nanoparticles have extraordinary characteristics that are helpful several applications, including wound dressings, microbial balance approaches, tissue regeneration, cancer treatment. Owing their large surface area, tailor-ability, persistent diameter, also used for engineering, controlled delivery, protective clothing. combination power generate enhanced performance over individual architectures. This review aims at illustrating main possibilities trends functionalized nanoparticles, focusing on inorganic organic polymer-based fibers. Emphasis recent progress fabrication procedures types description most polymers produce been undertaken, along bioactivity such alliances biomedical applications. To finish, future perspectives incorporated within clinical use presented discussed, thus showcasing relevant paths follow success field.

Language: Английский

Citations

24
Understanding Biomineralization Mechanisms to Produce Size-Controlled, Tailored Nanocrystals for Optoelectronic and Catalytic Applications: A Review DOI Creative Commons
Toriana N. Vigil, Leah C. Spangler

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(16), P. 18626 - 18654

Published: Feb. 29, 2024

Biomineralization, the use of biological systems to produce inorganic materials, has recently become an attractive approach for sustainable manufacturing functional nanomaterials. Relying on proteins or other biomolecules, biomineralization occurs under ambient temperatures and pressures, which presents easily scalable, economical, environmentally friendly method nanoparticle synthesis. Biomineralized nanocrystals are quickly approaching a quality applicable catalytic optoelectronic applications, replacing materials synthesized using expensive traditional routes. Here, we review current state development producing distill wide variety biosynthetic pathways into two main approaches: templating catalysis. Throughout, compare contrast syntheses, highlighting optimizations from syntheses that can be implemented improve biomineralized nanocrystal properties such as size morphology, making them competitive with chemically state-of-the-art

Language: Английский

Citations

11
Greening the pathways: a comprehensive review of sustainable synthesis strategies for silica nanoparticles and their diverse applications DOI Creative Commons

Arighna Saha,

Prashant Mishra, Goutam Biswas

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(16), P. 11197 - 11216

Published: Jan. 1, 2024

The graphical abstract describes several synthetic routes of SiNPs and wide range applications this nanoparticle.

Language: Английский

Citations

11
Harnessing the power of green synthesis of nanomaterials for anticancer applications: A review DOI
Roghaieh Holghoomi,

Zelal Kharab,

Abbas Rahdar

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 513, P. 215903 - 215903

Published: May 6, 2024

Language: Английский

Citations

11
An Overview of Current and Prognostic Trends on Synthesis, Characterization, and Applications of Biobased Silica DOI Creative Commons
Belete Tessema, Girma Gonfa, Sintayehu Mekuria Hailegiorgis

et al.

Advances in Materials Science and Engineering, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 23

Published: April 26, 2023

Silica has shown numerous applications in different fields such as environmental, biomedical, agriculture, and even chemical processing. However, due to high energy-intensive cost-effective issues, researchers show interest replace the conventional methods with biobased environmentally-friendly techniques for biosilica production from renewable biomass sources. Generally, silica is found be available amorphous crystalline structures. For commercial purposes, produced alkyl orthosilicates ore that consists of polyethlydiorthosilicate, tetraethyl ortothosilicate, tetramethyl orthosilicate. Another form silica, gel, selected resources biomass, palm tree, wheat straw, maize leaves, teff sugarcane bagasse, rice husk, leaf, oat bamboo corn cob. The gel agricultural residues a sustainable which receives significant attention can replaced inorganic-based environmental concerns. Based on this context, there huge look developing process produce low energy utilization promising alternatives methods. Keeping view, current trends synthesis, characterization well its wide prognostic were focused comprehensive review.

Language: Английский

Citations

22