Progress in brain research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Neural Regeneration Research, Journal Year: 2022, Volume and Issue: 18(4), P. 708 - 708
Published: Sept. 21, 2022
Alzheimer's disease is characterized by sustained neuroinflammation leading to memory loss and cognitive decline. The past decade has witnessed tremendous efforts in research; however, no effective treatment available prevent progression. An increasing body of evidence suggests that plays an important role pathogenesis, alongside the classical pathological hallmarks such as misfolded aggregated proteins (e.g., amyloid-beta tau). Firstly, this review summarized clinical characteristics disease. Secondly, we outlined key aspects glial cell-associated inflammation pathogenesis provided latest on roles microglia astrocytes pathology. Then, revealed double-edged nature inflammatory cytokines inflammasomes In addition, potential therapeutic innate immunity for were also discussed through these mechanisms. final section, remaining problems according current research status discussed.
Language: Английский
Citations
112
Journal of Chemistry, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 21
Published: May 31, 2024
Absorption of free radicals in the body cannot be done by antioxidant compounds originating from human body, so exogenous antioxidants are required to help their natural action. Oxidative stress can caused an imbalance radical inhibitors and accumulation that enter cellular structures. Synthetic found external not primary choice because they harmful carcinogenic. Therefore, using ingredients provides a necessary alternative constructing novel antioxidants. Recent studies have highlighted critical analysis evaluation flavonoids unique class secondary metabolites plants used communities as traditional therapeutics with proven bioactivity. This could support new discoveries based on various herbal medicines addition, functional effectiveness against radicals. In this review, there several strengths discussion. First, study takes comprehensive approach covering aspects, including properties sources radicals, oxidative relation different diseases, defense mechanisms, specific mechanisms flavonoids. Second, focus antioxidants, especially flavonoids, also discussion about clinical applications studies, limitations, global perspectives, future research directions become references selection medicines. But, constraints should considered when interpreting findings review. mechanism is only discussed general one example compound (flavonoid) has potential antioxidant. lack regarding relationship between diseases Third, limited number investigated some discussed.
Language: Английский
Citations
47
Cells, Journal Year: 2024, Volume and Issue: 13(10), P. 790 - 790
Published: May 7, 2024
Translational research in neurological and psychiatric diseases is a rapidly advancing field that promises to redefine our approach these complex conditions [...]
Language: Английский
Citations
19
Published: April 17, 2024
The editorial explores the realm of emerging translational research in neurology and psychiatry, providing insights into various subjects, including neurodegenerative disorders innovative therapeutic methods. main objective is to study neurological psychiatric disorders, such as Alzheimer's disease, with a particular emphasis on techniques for neural regeneration repair. highlights importance taking comprehensive approach studying treating complex conditions. This involves thoroughly reviewing papers causes, development, biomarkers, treatment options these emphasizes necessity using multidisciplinary integrative methods gain deeper understanding improve development an animal model recurrent primary dysmenorrhea showcases employed investigation gynecological illustrating capacity connect fundamental scientific knowledge practical medical applications. cooperative endeavors researchers clinicians emphasized this lay foundation revolutionary advancements that hold potential enhance outcomes individuals afflicted globally.
Language: Английский
Citations
18
Trends in Food Science & Technology, Journal Year: 2021, Volume and Issue: 116, P. 712 - 732
Published: Aug. 13, 2021
Language: Английский
Citations
73
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(5), P. 465 - 465
Published: March 4, 2024
Flexible electronics is a cutting-edge field that has paved the way for artificial tactile systems mimic biological functions of sensing mechanical stimuli. These have an immense potential to enhance human-machine interactions (HMIs). However, still faces formidable challenges in delivering precise and nuanced feedback, such as achieving high sensitivity emulate human touch, coping with environmental variability, devising algorithms can effectively interpret data meaningful diverse contexts. In this review, we summarize recent advances sensory systems, piezoresistive, capacitive, piezoelectric, triboelectric sensors. We also review state-of-the-art fabrication techniques Next, focus on applications HMIs, intelligent robotics, wearable devices, prosthetics, medical healthcare. Finally, conclude future development trends
Language: Английский
Citations
16
Food Innovation and Advances, Journal Year: 2023, Volume and Issue: 2(4), P. 272 - 290
Published: Jan. 1, 2023
Recently, there has been a growing focus on researching ways to delay aging and protect against age-related illnesses. Small molecular exogenous peptides, sourced from dietary elements like animals, plants, microorganisms, have demonstrated considerable potential in exerting anti-aging effects. Notably, natural food-derived peptides exhibited enhanced stability, safety, absorption efficiency, heightened biological activity. These attributes position them with greater for mitigating aging-related disorders compared alternative drugs or phytochemicals. This review summarizes the origins, structural attributes, isolation methods of properties. It also explores how these external improve conditions such as neurodegenerative diseases, skin aging, metabolic disorders. The underlying mechanisms dictating their impact well-conserved signaling pathways—encompassing oxidative stress, inflammation, apoptosis, collagen synthesis—are meticulously elucidated. paper engages an insightful exploration key challenges pivotal trajectories, grounded ongoing research endeavors. As result, this is poised offer authoritative scientific guidance invaluable support practical implementation realm applications within food, pharmaceutical, cosmetic industries.
Language: Английский
Citations
18
Metabolic Brain Disease, Journal Year: 2024, Volume and Issue: 39(5), P. 833 - 840
Published: April 30, 2024
Language: Английский
Citations
7
Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 20
Published: Aug. 26, 2022
Molecules with at least one unpaired electron in their outermost shell are known as free radicals. Free radical molecules produced either within our bodies or by external sources such ozone, cigarette smoking, X-rays, industrial chemicals, and air pollution. Disruption of normal cellular homeostasis redox signaling may result cardiovascular, neurodegenerative diseases cancer. Although ROS (reactive oxygen species) formed the GI tract, little is about how they contribute to pathophysiology disease etiology. When reactive species antioxidants imbalance bodies, can cause cell structure damage, diseases, diabetes, hypercholesterolemia, atherosclerosis, cancer, cardiovascular metabolic disorders, other obesity-related well protein misfolding, mitochondrial dysfunction, glial activation, subsequent apoptosis. Neuron cells gradually destroyed diseases. The production inappropriately aggregated proteins strongly linked oxidative stress. This review’s goal provide much information possible numerous illnesses possibilities multimodal neuroprotective therapy human illness, using already accessible medications demonstrating promise animal models, highlighted. Neuroprotection neurolongevity improve from use bioactive substances medicinal herbs like Allium stadium, Celastrus paniculatus, Centella asiatica. Many drugs’ role has been addressed. Preventing neuroinflammation demonstrated several models.
Language: Английский
Citations
27
General Psychiatry, Journal Year: 2024, Volume and Issue: 37(1), P. e101181 - e101181
Published: Feb. 1, 2024
The neurophysiological differences in cortical plasticity and cholinergic system function due to ageing their correlation with cognitive remain poorly understood. To reveal the long-term potentiation (LTP)-like short-latency afferent inhibition (SAI) between older younger individuals, alongside using transcranial magnetic stimulation (TMS). cross-sectional study involved 31 adults aged 18-30 46 60-80. All participants underwent comprehensive assessments a evaluation based on TMS. Cognitive included evaluations of global function, language, memory executive function. assessment LTP-like SAI. findings this revealed decline LTP among compared (wald χ2=3.98, p=0.046). Subgroup analysis further demonstrated significant reduction SAI level individuals 70-80 years comparison both (SAI(N20): (t=-3.37, p=0.018); SAI(N20+4): (t=-3.13, p=0.038)) those 60-70 (t=-3.26, p=0.025); (t=-3.69, p=0.006)). Conversely, there was no notable difference group. Furthermore, after employing Bonferroni correction, that only positive language (r=0.61, p<0.001) group remained statistically significant. During normal process, synaptic may precede dysfunction. In over 60 age, is plasticity, while observed 70. Thus, play vital role preventing during ageing. might represent potential marker for
Language: Английский
Citations
6