Antimicrobial nanoparticles: current landscape and future challenges

RSC Pharmaceutics, Journal Year: 2024, Volume and Issue: 1(3), P. 388 - 402

Published: Jan. 1, 2024

Antimicrobial resistance poses a serious threat to global health, necessitating the exploration of innovative solutions.

Language: Английский

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Novel functionalized phenyl acetate derivatives of benzo [e]-bispyrone fused hybrids: Synthesis and biological activities

Results in Chemistry, Journal Year: 2023, Volume and Issue: 5, P. 100942 - 100942

Published: Jan. 1, 2023

Eighteen novel functionalized phenyl acetate derivatives of benzo[e]-bispyrone fused hybrids and their three precursors are developed in this study. The precursor acetic acid congeners (Y1, Y8, Y15) were created by combining acetone dicarboxylic resorcinol-based compounds. They utilized the preparation (Y2-Y7, Y9-Y14, Y16-Y21). Six vitro biological activities investigated for synthesized derivatives. First, reactive species-caging activity was tested against DPPH hydroxyl radicals. Second, cellular viability-terminating assayed using MTT-visual probing methodology six common cancerous cell lines. Third, fourth, fifth activities, collectively termed microbial-shedding potential, examined a microdilution broth aerobic pathogenic bacterial strains, four anaerobic two fungal respectively. Finally, blood sugar-dropping assessed related enzymes. Moreover, toxic effects twenty-one compounds one normal human line non-pathogenic strain. results showed that hybrids' methoxyphenyl (Y2, Y9, Y16) had greatest species-caging, bacterial-shooting, activities. In terms activity, fluorophenyl (Y4, Y11, Y18) demonstrated lines while causing least toxicity to line. Chlorophenyl highest pathogen-shedding on strains (Y5, Y12, Y19). with flourophenyl or chlorophenyl levels fungal-shooting exceeding reference. researchers concluded from these observations provided several biosafe scaffolds multiple selective

Language: Английский

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Harmful Free Radicals in Aging: A Narrative Review of Their Detrimental Effects on Health

Indian Journal of Clinical Biochemistry, Journal Year: 2023, Volume and Issue: 39(2), P. 154 - 167

Published: Aug. 1, 2023

Language: Английский

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Combretastatin A4-based coumarins: synthesis, anticancer, oxidative stress-relieving, anti-inflammatory, biosafety, and in silico analysis

Chemical Papers, Journal Year: 2024, Volume and Issue: 78(6), P. 3705 - 3720

Published: Feb. 18, 2024

Language: Английский

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6,7-Coumarin-heterocyclic hybrids: A comprehensive review of their natural sources, synthetic approaches, and bioactivity

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1303, P. 137601 - 137601

Published: Jan. 22, 2024

Language: Английский

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Coumarin hybrids for targeted therapies: A promising approach for potential drug candidates

Phytochemistry Letters, Journal Year: 2024, Volume and Issue: 60, P. 117 - 133

Published: Feb. 8, 2024

Language: Английский

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Biocompatible chlorocoumarins from harmful chlorophenols, their synthesis and biomedicinal evaluation

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1309, P. 138193 - 138193

Published: March 30, 2024

Language: Английский

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Coumarins from carcinogenic phenol: synthesis, characterization, in silico, biosafety, anticancer, antioxidant, and anti-inflammatory assessments

Chemical Papers, Journal Year: 2023, Volume and Issue: 78(1), P. 493 - 504

Published: Oct. 9, 2023

Language: Английский

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Synthesis, in silico analysis, and biomedical effects of coumarins derived from resveratrol

Phytomedicine Plus, Journal Year: 2023, Volume and Issue: 3(4), P. 100501 - 100501

Published: Nov. 1, 2023

: Resveratrol (RVL) is a polyphenol-containing natural product found in variety of plants, including peanuts, grapes, and berry fruits. The use RVL linked great deal research to number therapeutic properties. In an attempt improve these properties, five RVL-based coumarins, abbreviated YF1-YF5, were synthesized structurally constructed pathway. molecular architecture our coumarins was confirmed by analyzing their FTIR NMR spectra. biomedical effects the investigated compared with precursor. first dual 5-LOX/COX inhibitory effect, which tested versus three related enzymes. second free-radical neutralizing estimated against two radical phenotypes. third apoptotic-inducing evaluated four tumorous cell lines. fourth high blood-glucose regulatory effect assessed corresponding Finally, bacterial growth-suppressing pathogenic strains. pharmacokinetic identifiers compounds also silico matched analyze chemical functionalization. findings indicated that exhibited enhanced building moiety. best reported for YF3, lowest attributed YF5. This improvement coupled advancements identifiers. According outcomes, authors concluded provide intriguing modification improving its effects.

Language: Английский

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Emerging trends and future opportunities for coumarin-heterocycle conjugates as antibacterial agents

Results in Chemistry, Journal Year: 2023, Volume and Issue: 6, P. 101151 - 101151

Published: Oct. 5, 2023

Infectious diseases resulting from various strains of pathogenic bacteria are among the leading causes death and morbidity worldwide. The currently-available antibacterial medications developed natural or synthetic sources cornerstone bacterial infection intervention, but somehow mounting spread expansion multidrug-resistant harmful has become a major concern for medical-providing communities pharmaceutical-releasing companies. pervasiveness coumarin-based products in nature simplicity their lab chemical synthesis, addition to ability coumarin backbone communicate, may interact with DNA gyrase at B subunit hinder secondary structure by abolishing ATPase activity; thus, conjugates have potential act as agents. It is conceivable that conjugation nucleus other heterocyclic-based scaffolds present opportunities creation novel drugs. This presentation be based on fact several coumarin-heterocycle conjugates, including clorobiocin, coumermycin A1, novobiocin, already been used medical methods treatment infectious diseases. study explores, during period last 5 years, relationships between activity action. investigation also explored developing these into medicines.

Language: Английский

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