Potential Strategies for Overcoming Drug Resistance Pathways Using Propolis and Its Polyphenolic/Flavonoid Compounds in Combination with Chemotherapy and Radiotherapy DOI Open Access
Nada Oršolić, Maja Jazvinšćak Jembrek

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3741 - 3741

Published: Oct. 31, 2024

Conventional cancer treatments include surgical resection, chemotherapy, hyperthermia, immunotherapy, hormone therapy, and locally targeted therapies such as radiation therapy. Standard often require the use of multiple agents, which can activate nuclear factor kappa B (NF-κB) in tumor cells, leading to reduced cell death increased drug resistance. Moreover, agents also contributes added toxicity, resulting poor treatment outcomes. Cancer cells gradually develop resistance almost all chemotherapeutics through various mechanisms, efflux, alterations metabolism transport, changes signal transduction pathways, enhanced DNA repair capacity, evasion apoptosis, mutations, reactivation targets, interaction with microenvironment, cell-stroma interactions, epithelial–mesenchymal transition (EMT)-mediated chemoresistance, epigenetic modifications, metabolic alterations, effect stem (CSCs). Developing new strategies improve chemotherapy sensitivity while minimizing side effects is essential for achieving better therapeutic outcomes enhancing patients’ quality life. One promising approach involves combining conventional propolis its flavonoids. These natural compounds may enhance response reducing toxicity. Propolis components sensitize chemotherapeutic likely by inhibiting NF-κB activation, reprogramming tumor-associated macrophages (TAMs; an M2-like phenotype), thereby release matrix metalloproteinase (MMP)-9, cytokines, chemokines, vascular endothelial growth (VEGF). By TAMs, overcome EMT-mediated disrupt crosstalk between CSCs, inhibit maintenance stemness, reverse acquired immunosuppression, thus promoting antitumor mediated cytotoxic T-cells. This review highlights potential flavonoids modulate responsiveness modalities. The evidence suggests that novel incorporating could be developed positive cytotoxicity peripheral blood leukocytes, liver, kidney cells. Therefore, polyphenolic/flavonoid hold combination clinical types cancers.

Language: Английский

Natural Products as Anticancer Agents: Current Status and Future Perspectives DOI Creative Commons
Abid Naeem,

Pengyi Hu,

Ming Yang

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(23), P. 8367 - 8367

Published: Nov. 30, 2022

Natural products have been an invaluable and useful source of anticancer agents over the years. Several compounds synthesized from natural by modifying their structures or using naturally occurring as building blocks in synthesis these for various purposes different fields, such biology, medicine, engineering. Multiple modern costly treatments applied to combat cancer limit its lethality, but results are not significantly refreshing. products, which a significant new therapeutic drugs, currently being investigated potential cytotoxic shown positive trend preclinical research prompted numerous innovative strategies order expedite clinical research. becoming increasingly important drug discovery due high molecular diversity novel biofunctionality. Furthermore, can provide superior efficacy safety unique properties. The objective current review is overview emergence treatment prevention cancer, chemosensitizers, immunotherapeutics, combinatorial therapies with other formulations mechanisms underlying

Language: Английский

Citations

251
Steroidal Saponins: Naturally Occurring Compounds as Inhibitors of the Hallmarks of Cancer DOI Open Access
Salwa Bouabdallah,

Amna Al-Maktoum,

Amr Amin

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(15), P. 3900 - 3900

Published: July 31, 2023

Cancer is a global health burden responsible for an exponentially growing number of incidences and mortalities, regardless the significant advances in its treatment. The identification hallmarks cancer major milestone understanding mechanisms that drive initiation, development, progression. In past, have been targeted to effectively treat various types cancers. These conventional drugs shown therapeutic efficacy but continue impose unfavorable side effects on patients. Naturally derived compounds are being tested search alternative anti-cancer drugs. Steroidal saponins group naturally occurring primarily exist as secondary metabolites plant species. Recent studies suggested steroidal possess capabilities. This review aims summarize recent findings inhibitors covers key published between years 2014 2024. It reported inhibit cancer, poor bioavailability insufficient preclinical limit their utilization.

Language: Английский

Citations

50
Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges. DOI Creative Commons
Great Iruoghene Edo, Alice Njolke Mafe, Patrick Othuke Akpoghelie

et al.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754

Published: Jan. 1, 2025

Language: Английский

Citations

2
Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review DOI Open Access
Ridhima Kaul, Pradipta Paul, Sanjay Kumar

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(20), P. 11069 - 11069

Published: Oct. 14, 2021

The ongoing COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over past two years. Despite development and administration of multiple vaccines, mutation newer strains challenges to universal immunity has shifted focus lack efficacious drugs for therapeutic intervention disease. As with SARS-CoV, MERS-CoV, other non-respiratory viruses, flavonoids present themselves as promising given their success in silico, vitro, vivo, more recently, clinical studies. This review focuses on data from vitro studies analyzing effects various key SARS-CoV-2 targets presents an analysis structure-activity relationships same. From 27 primary papers, 69 were investigated activities against targets, ranging 3C-like protease (3CLpro) less explored nucleocapsid (N) protein; most quercetin myricetin derivatives, baicalein, baicalin, EGCG, tannic acid. We further silico featuring list involving potential flavonoid-rich extracts combination synthetic or polyphenols suggest prospects future SARS-CoV-2.

Language: Английский

Citations

84
Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care DOI Creative Commons
Alena Mazuráková, Lenka Koklesová, Marek Samec

et al.

The EPMA Journal, Journal Year: 2022, Volume and Issue: 13(2), P. 315 - 334

Published: April 14, 2022

Breast cancer incidence is actually the highest one among all cancers. Overall breast management associated with challenges considering risk assessment and predictive diagnostics, targeted prevention of metastatic disease, appropriate treatment options, cost-effectiveness approaches applied. Accumulated research evidence indicates promising anti-cancer effects phytochemicals protecting cells against malignant transformation, inhibiting carcinogenesis spread, supporting immune system increasing effectiveness conventional therapies, others. Molecular sub-/cellular mechanisms are highly complex affecting several pathways considered potent targets for advanced diagnostics cost-effective treatments. Demonstrated affects, therefore, clinically relevant improving individual outcomes might be applicable to primary (protection initial development), secondary potential disease tertiary (towards cascading complications) care. However, a detailed data analysis essential adapt algorithms individuals' patients' needs. Consequently, concepts patient stratification, prevention, treatments tailored individualized profile instrumental application natural substances improve overall benefiting affected individuals society at large.

Language: Английский

Citations

54
Genesis and Mechanism of Some Cancer Types and an Overview on the Role of Diet and Nutrition in Cancer Prevention DOI Creative Commons
Nurkhalida Kamal,

Muna Ilowefah,

Ayah Rebhi Hilles

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(6), P. 1794 - 1794

Published: March 9, 2022

Cancer is a major disease with high mortality rate worldwide. In many countries, cancer considered to be the second most common cause of death after cardiovascular disease. The clinical management continues challenge as conventional treatments, such chemotherapy and radiation therapy, have limitations due their toxicity profiles. Unhealthy lifestyle poor dietary habits are key risk factors for cancer; having healthy diet may minimize risk. Epidemiological studies shown that fruit vegetable intake in our regular can effectively reduce developing certain types cancers contents antioxidants phytochemicals. vitro vivo phytochemicals exert significant anticancer effects free radical scavenging capacity potential. There has been extensive research on protective different cancers. This review attempts give an overview etiology assesses role phytonutrients prevention cancers, which makes present distinct from others available.

Language: Английский

Citations

50
Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection DOI Creative Commons
Hardeep Singh Tuli, Vivek Kumar Garg,

Sakshi Bhushan

et al.

Translational Oncology, Journal Year: 2022, Volume and Issue: 27, P. 101596 - 101596

Published: Dec. 5, 2022

Cancer prevalence and its rate of incidence are constantly rising since the past few decades. Owing to toxicity present-day antineoplastic drugs, it is imperative explore safer more effective molecules combat and/or prevent this dreaded disease. Flavonoids, a class polyphenols, have exhibited multifaceted implications against several diseases including cancer, without showing significant towards normal cells. Shredded pieces evidence suggest that flavonoids can enhance drug sensitivity suppress proliferation, metastasis, angiogenesis cancer cells by modulating oncogenic or oncosuppressor microRNAs (miRNAs, miRs). They play pivotal roles in regulation various biological pathological processes, cancers. In present review, structure, chemistry miR targeting efficacy quercetin, luteolin, silibinin, genistein, epigallocatechin gallate, cyanidin types comprehensively discussed. miRs considered as next-generation medicine recent times, their naturally occurring could be deemed signature step. We anticipate our compilations related miRNA-mediated might catapult clinical investigations affirmation future.

Language: Английский

Citations

47
Nobiletin as an inducer of programmed cell death in cancer: a review DOI
Jun Huang, Zaoshang Chang, Quzhe Lu

et al.

APOPTOSIS, Journal Year: 2022, Volume and Issue: 27(5-6), P. 297 - 310

Published: March 21, 2022

Language: Английский

Citations

44
Prostate cancer treatment costs increase more rapidly than for any other cancer—how to reverse the trend? DOI Creative Commons
Jörg Ellinger,

Abdullah Alajati,

Peter Kubatka

et al.

The EPMA Journal, Journal Year: 2022, Volume and Issue: 13(1), P. 1 - 7

Published: March 1, 2022

According to GLOBOCAN, about 1.41 million new prostate cancer (PCa) cases were registered in the year 2020 globally. The corresponding socio-economic burden is enormous. Anti-cancer mRNA-based therapy a promising approach, principle of which currently applied for anti-COVID-19 vaccination, undergoing detailed investigation populations considering its short- and long-term effectiveness potential side effects. Pragmatically considered, it will take years or even decades make mRNA working any type cancers, if possible, individual malignancy sub-types are many specifically PCa. Actually, costs treating PCa increasing more rapidly than those other cancer. trend has be reversed now, not couple years. In general, two main components making reactive (management clinically manifested disease) treatment particularly expensive. On one hand, incidence disease metastatic as subtype. To this end, rates young middle-aged male sub-populations should taken into account contributor potentially developed later on life. patient stratification differentiate between non-metastatic (no need an extensive costly treatment) aggressive subtypes requiring personalised algorithms challenging. Considering current statistics, becomes obvious that medicine got at limit management. Multi-professional expertise unavoidable create implement anti-PCa programmes population. our strategic paper, we exemplify challenging management by providing expert recommendations primary (health risk assessment), secondary (prediction prevention PCa) tertiary (making palliative care chronic framework predictive, preventive medicine.

Language: Английский

Citations

40
Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer DOI Creative Commons

Maria Beatriz Madureira,

Virgínia Márcia Concato, Ellen Mayara Souza Cruz

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 586 - 586

Published: Feb. 27, 2023

Citrus (genus L.) fruits are essential sources of bioactive compounds with antioxidant properties, such as flavonoids. These polyphenolic divided into subclasses, in which flavanones the most prominent. Among them, naringenin and hesperidin emerging anticancer potential, especially for breast cancer (BC). Several mechanisms have been proposed, including modulation epigenetics, estrogen signaling, induction cell death via regulation apoptotic signaling pathways, inhibition tumor invasion metastasis. However, this information is sparse literature needs to be brought together provide an overview how can serve therapeutic tools drug development a successful co-adjuvant strategy against BC. This review detailed context highlighted could interfere BC carcinogenesis helpful potential alternative treatment.

Language: Английский

Citations

35