Emerging role and clinical applications of circular RNAs in human diseases

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 28, 2025

Language: Английский

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Advancements in current one-size-fits-all therapies compared to future treatment innovations for better improved chemotherapeutic outcomes: a step-toward personalized medicine

Current Medical Research and Opinion, Journal Year: 2024, Volume and Issue: 40(11), P. 1943 - 1961

Published: Oct. 16, 2024

The development of therapies followed a generalized approach for long time, assuming that single treatment could effectively address various patient populations. However, recent breakthroughs have revealed the limitations this one-size-fits-all paradigm. More recently, field therapeutics has witnessed shift toward other modules, including cell therapies, high molecular weight remedies, personalized medicines, and gene therapies. Such advancements in therapeutic modules potential to revolutionize healthcare pave way medicines are more efficient with minimal side effects. Cell gained considerable attention regenerative medicine. Stem cell-based instance, hold promise tissue repair regeneration, ongoing research focusing on enhancing their efficacy safety. High drugs like peptides proteins emerged as promising because specificity diverse biological functions. Engineered developed targeted drug delivery, immunotherapy, disease-modulation. In medicine, tailored treatments individuals based specific genetic profiling, lifestyle, biomarkers, disease characteristics all implemented. Clinicians optimize outcomes minimize adverse effects, using mutations, yielding remarkable results. Gene revolutionized disorders by directly targeting underlying abnormalities. Innovative techniques, such CRISPR-Cas9 allowed precise editing, opening up possibilities curing previously incurable conditions. conclusion,

Language: Английский

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Establishment of a novel lysosomal signature for the diagnosis of gastric cancer with in-vitro and in-situ validation

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 5, 2023

Background Gastric cancer (GC) represents a malignancy with multi-factorial combination of genetic, environmental, and microbial factors. Targeting lysosomes presents significant potential in the treatment numerous diseases, while lysosome-related genetic markers for early GC detection have not yet been established, despite implementing this process by assembling artificial intelligence algorithms would greatly break through its value translational medicine, particularly immunotherapy. Methods To end, study, utilizing transcriptomic as well single cell data integrating 20 mainstream machine-learning (ML) algorithms. We optimized an AI-based predictor diagnosis. Then, reliability model was initially confirmed results enrichment analyses currently use. And immunological implications genes comprising explored response patients were evaluated to immunotherapy chemotherapy. Further, we performed systematic laboratory work evaluate build-up central genes, both at expression stage functional aspect, which could also demonstrate guide Results Eight lysosomal-related selected predictive construction based on inclusion RMSE reference standard RF algorithm ranking, namely ADRB2, KCNE2, MYO7A, IFI30, LAMP3, TPP1, HPS4, NEU4. Taking into account accuracy, precision, recall, F1 measurements, preliminary determination our study carried out means applying extra tree random forest algorithms, incorporating ROC-AUC consideration, Extra Tree seems be optimal option AUC 0.92. The superiority diagnostic signature is reflected analysis immune features. Conclusion In summary, first integrate around ML construct gastric genes. This will facilitate accurate prediction incidence subsequent risk assessment or precise individualized immunotherapy, thus improving survival prognosis patients.

Language: Английский

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Differential Signaling Pathways in Medulloblastoma: Nano-biomedicine Targeting Non-coding Epigenetics to Improve Current and Future Therapeutics

Current Pharmaceutical Design, Journal Year: 2023, Volume and Issue: 30(1), P. 31 - 47

Published: Dec. 28, 2023

Medulloblastomas (MDB) are malignant, aggressive brain tumors that primarily affect children. The survival rate for children under 14 is approximately 72%, while ages 15 to 39, it around 78%. A growing body of evidence suggests dysregulation signaling mechanisms and noncoding RNA epigenetics play a pivotal role in this disease.

Language: Английский

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Iron oxide nanoparticles: a narrative review of in-depth analysis from neuroprotection to neurodegeneration

Environmental Science Advances, Journal Year: 2024, Volume and Issue: 3(5), P. 635 - 660

Published: Jan. 1, 2024

Iron oxide nanoparticles (IONPs) are ubiquitous in nature. They can play dual functions, one neuroprotection and other neurodegeneration.

Language: Английский

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Long COVID as a Tauopathy: Of “Brain Fog” and “Fusogen Storms”

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12648 - 12648

Published: Aug. 10, 2023

Long COVID, also called post-acute sequelae of SARS-CoV-2, is characterized by a multitude lingering symptoms, including impaired cognition, that can last for many months. This symptom, often "brain fog", affects the life quality numerous individuals, increasing medical complications as well healthcare expenditures. The etiopathogenesis SARS-CoV-2-induced cognitive deficit unclear, but most likely cause chronic inflammation maintained viral remnant thriving in select body reservoirs. These sanctuaries are comprised fused, senescent cells, microglia and astrocytes, pathogen convert into neurotoxic phenotypes. Moreover, enteric nervous system contains neurons glia, virus lingers gastrointestinal tract well, accounting intestinal symptoms long COVID. Fusogens proteins overcome repulsive forces between cell membranes, allowing to coalesce with host cells enter cytoplasm. In intracellular compartment, hijacks actin cytoskeleton, fusing each other engendering pathological syncytia. Cell-cell fusion enables infect healthy neighboring cells. We surmise syncytia formation drives impairment facilitating "seeding" hyperphosphorylated Tau, documented COVID-19. our previous work, we hypothesized SARS-CoV-2 induces premature endothelial senescence, permeability blood-brain barrier. migration microbes and/or their components circulation, eventually reaching brain where they may induce dysfunction. For example, translocated lipopolysaccharides or microbial DNA Tau hyperphosphorylation, memory problems. this perspective article, examine pathogenetic mechanisms potential biomarkers cell-free DNA, interleukin 22, phosphorylated beneficial effect transcutaneous vagal nerve stimulation.

Language: Английский

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Multiomics as instrument to promote 3P medical approaches for the overall management of respiratory syncytial viral infections

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

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LincRNA-miR interactions in hepatocellular carcinoma: comprehensive review and in silico analysis: a step toward ncRNA precision

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: May 23, 2025

Language: Английский

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Emerging roles of non-coding RNA derived from extracellular vesicles in regulating PD-1/PD-L1 pathway: insights into cancer immunotherapy and clinical applications

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 23, 2025

Language: Английский

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Impact of airborne iron oxide nanoparticles on Tillandsia usneoides as a model plant to assess pollution in heavy traffic areas

Chemosphere, Journal Year: 2024, Volume and Issue: 355, P. 141765 - 141765

Published: March 24, 2024

Due to the increasing evidence of widespread sub-micron pollutants in atmosphere, impact airborne nanoparticles is a subject great relevance. In particular, smallest particles are considered most active and dangerous, having higher surface/volume ratio. Here we tested effect iron oxide (Fe3O4) (IONPs) with different mean diameter size distribution on model plant Tillandsia usneoides. Strands were placed home-built closed boxes exposed levels IONPs reported for roadside air, i.e. order 107 - 108 items m−2. Plant growth other morpho-physiological parameters monitored two weeks, showing that exposure significantly reduced length increment treated strands respect controls. A dose-dependence this impairing was found only few tens nanometers. These also proved be toxic at highest concentration tested. The IONP-induced hamper correlated altered macro- micronutrients plant, while no significant variation photosynthetic activity detected samples. Microscopy investigation showed could adhere surface preferentially located trichome wings. Our results report, first time, negative effects IONP pollution health, thus raising concerns about related environmental risks. Future research should devoted species assess plants devise suitable attenuation practices.

Language: Английский

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