Targeting selective autophagy and beyond: From underlying mechanisms to potential therapies

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: 65, P. 297 - 327

Published: May 14, 2024

Autophagy is an evolutionarily conserved turnover process for intracellular substances in eukaryotes, relying on lysosomal (in animals) or vacuolar yeast and plants) mechanisms. In the past two decades, emerging evidence suggests that, under specific conditions, autophagy can target particular macromolecules organelles degradation, a termed selective autophagy. Recently, accumulating studies have demonstrated that abnormality of closely associated with occurrence progression many human diseases, including neurodegenerative cancers, metabolic cardiovascular diseases. This review aims at systematically comprehensively introducing its role various while unravelling molecular mechanisms By providing theoretical basis development related small-molecule drugs as well treating this seeks to contribute understanding therapeutic potential. review, we introduce dissect major categories been discovered. We also focus recent advances underlying both classical non-classical Moreover, current situation targeting different types further summarized, valuable insights into discovery more candidate future. On other hand, reveal clinically relevant implementations are potentially autophagy, such predictive approaches treatments tailored individual patients.

Language: Английский

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Revolutionizing Gastrointestinal Disorder Management: Cutting-Edge Advances and Future Prospects

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(13), P. 3977 - 3977

Published: July 8, 2024

In recent years, remarkable strides have been made in the management of gastrointestinal disorders, transforming landscape patient care and outcomes. This article explores latest breakthroughs field, encompassing innovative diagnostic techniques, personalized treatment approaches, novel therapeutic interventions. Additionally, this emphasizes use precision medicine tailored to individual genetic microbiome profiles, application artificial intelligence disease prediction monitoring. review highlights dynamic progress managing conditions such as inflammatory bowel disease, gastroesophageal reflux irritable syndrome, cancers. By delving into these advancements, we offer a glimpse promising future gastroenterology, where multidisciplinary collaborations cutting-edge technologies converge provide more effective, patient-centric solutions for individuals grappling with disorders.

Language: Английский

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Multiomics as instrument to promote 3P medical approaches for the overall management of respiratory syncytial viral infections

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

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Physical Exercise Alleviates Oxidative Stress and Autonomic Dysregulation in a Rat Model of Inflammatory Bowel Disease

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 328 - 328

Published: March 10, 2025

Inflammatory bowel disease (IBD) induces immunological and autonomic imbalances. Exercise is a beneficial strategy for controlling IBD symptoms. We investigated the role of exercise on gastrointestinal (GI) motility changes parameters in rats with ileitis. Rats were divided into control, ileitis, exercise+ileitis groups. Ileitis was induced by TNBS (40 mM, intraileally). The swimming (1 h/day/4 weeks, 5%/bw). assessed eating behaviour oxidative stress. Body composition bioimpedance. Autonomic balance ECG measured an electrocardiogram (ECG). Gastrointestinal evaluated using phenol red technique. In terms body composition, total water (TBW), mass index (BMI), fat-free (FFM) higher ileitis group (216.80 ± 11.44 mL; 24.09 2.15 g/cm2; 287.1 14.66 g) (p < 0.05) vs. control (130.06 28.23 16.38 2.50 193 42.21 prevented (91.33 12.33 11.73 0.47 133.8 16.82 these changes. reduction gastric retention (11.22 1.91% 35.17 1.01% 33.96 1.77%). increased intestinal duodenum (46.3 2.56% 24.98 1.78%) jejunum (34.22 2.33% 34.72 2.83% 47.32 1.48%) decreased ileum group. Exercise+ileitis (24.96 1.66% 46.3 2.56%) (40.32 3.75% 14.08 0.88%). high MDA levels (4.43 0.69 0.12 nmol/mg tissue). This effect (2.75 0.21 4.43 observed LF component (31.32 3.99 43.43 3.86). correlation indicated stronger interrelationship between parameter (r: 0.68; p: 0.04). current study suggests alters GI balance, physical can represent essential non-pharmacological approach to treatment.

Language: Английский

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Personalization of thiopurine therapy: Current recommendations and future perspectives

Acta Pharmaceutica, Journal Year: 2024, Volume and Issue: 74(3), P. 355 - 381

Published: Sept. 1, 2024

Abstract Despite great therapeutic advances in the field of biologics, small synthetic molecules such as thiopurines, including azathioprine, mercaptopurine, and thioguanine, remain an important pillar treatment inflammatory bowel disease, other autoimmune disorders, cancer. This review presents latest guidelines for thiopurine administration, highlighting importance individualized therapy guided by pharmacogenomics. It emphasizes dose adjustment based on nudix hydrolase 15 ( NUDT15 ) S -methyltransferase TPMT genotype, along side activity metabolic profile. In addition, article takes a critical look at emerging research pharmaco genomics featuring novel genetic markers technological developments testing. Finally, potential integrated approaches that combine genetic, meta bolic, clinical factors to further individualize is highlighted.

Language: Английский

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Mendelian randomization reveals predictive, preventive, and personalized insights into inflammatory bowel disease: the role of gut microbiome and circulating inflammatory proteins

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(4), P. 693 - 709

Published: Nov. 12, 2024

Language: Английский

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