Microbiological Research, Journal Year: 2023, Volume and Issue: 279, P. 127548 - 127548
Published: Nov. 20, 2023
Language: Английский
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 313, P. 120746 - 120746
Published: Feb. 28, 2023
Language: Английский
Citations
61
Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106690 - 106690
Published: Jan. 28, 2025
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2615 - 2615
Published: Jan. 30, 2023
The marine polysaccharide fucoidan (FUC) is a promising polymer for pharmaceutical research and development of novel drug delivery systems with modified release targeted delivery. presence sulfate group in the makes FUC an excellent candidate formation interpolyelectrolyte complexes (PECs) various polycations. However, due to structural diversity FUC, design FUC-based nanoformulations challenging. This review describes main strategies use PECs develop improved biopharmaceutical properties, including nanocarriers form FUC-chitosan pH-sensitive oral delivery, systems, polymeric nanoparticles hydrophobic (e.g., FUC-zein PECs, core-shell structures obtained by layer-by-layer self-assembly method, self-assembled hydrophobically particles). importance complex study structure, process based on it obtaining reproducible desired also discussed.
Language: Английский
Citations
24
Plants, Journal Year: 2023, Volume and Issue: 12(13), P. 2445 - 2445
Published: June 25, 2023
Brown macroalgae represent one of the most proliferative groups living organisms in aquatic environments. Due to their abundance, they often cause problems and terrestrial ecosystems, resulting health humans death various species. To resolve this, application Sargassum has been sought different research areas, such as food, pharmaceuticals, cosmetics, since is an easy target for study simple obtain. In addition, its high content biocompounds, polysaccharides, phenols, amino acids, among others, attracted attention. One valuable components brown which present interesting bioactivities, antiviral, antimicrobial, antitumoral, others. There a wide variety methods extraction currently used obtain these supercritical fluid (SFE), pressurized liquid (PLE), subcritical water (SCWE), ultrasound-assisted (UAE), enzyme-assisted (EAE), microwave-assisted (MAE). Therefore, this work covers current information on extraction, well purification polysaccharide from that able be utilized alginates, fucoidans, laminarins. compilation bioactivities involving algae polysaccharides vivo vitro studies also presented, along with challenges marketing Sargassum-based products are commercially available.
Language: Английский
Citations
24
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: April 12, 2024
A large number of microbial species tend to communicate and produce biofilm which causes numerous infections, antibiotic resistance, economic problems across different industries. Therefore, advanced anti-biofilms are required with novel attributes targets, such as quorum sensing communication system. Meanwhile, inhibitors promising anti-biofilm molecules result in the inhibition particular phenotype expression blocking cell-to-cell communication, would be more acceptable than conventional strategies. Many natural products identified agents from plants, microorganisms, marine extracts. Marine algae sources broadly compounds activity. Algae extracts their metabolites sulfated polysaccharides (fucoidan), carotenoids (zeaxanthin lutein), lipid fatty acids (γ-linolenic acid linoleic acid), phlorotannins can inhibit cell attachment, reduce growth, interfere pathway by related enzymes, disrupt extracellular polymeric substances. In this review, mechanisms formation, pathway, recently will discussed.
Language: Английский
Citations
16
Carbohydrate Research, Journal Year: 2024, Volume and Issue: 538, P. 109071 - 109071
Published: March 4, 2024
Language: Английский
Citations
13
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 332, P. 121884 - 121884
Published: Jan. 29, 2024
Language: Английский
Citations
12
Journal of Agriculture and Food Research, Journal Year: 2024, Volume and Issue: 16, P. 101189 - 101189
Published: May 6, 2024
Probiotics, the health-promoting members of gut microbiota, have been shown to enhance mucosal and systemic immunity, stimulate cytokines, chemokines, antibodies, regulate T-cell activity. On other hand, traditional adjuvants like alum limitations, researchers are exploring probiotics as a new generation vaccine treat immune disorders effectiveness. For instance, studies show that probiotic strains Lactobacillus rhamnosus GG (LGG) can improve response vaccines against rotavirus, SARS-CoV-2, influenza. Besides, delivered through various routes (oral ocular) could offer broader protection wider range infections. not only boost system but also trigger production anti-inflammatory cytokines regulatory cells, they potential in cancer immunotherapy. Studies demonstrate LGG Bifidobacterium longum increase efficacy by promoting T cell infiltration, thereby inhibiting tumor growth. Additionally, suggest specific L. SL42 casei might be beneficial for cow's milk allergies. In line with this, research on use peanut allergies shows promise. However, there is need more understand mechanisms, identify optimal strains, determine timing duration administration clinical outcomes. This review aimed shed light impact immunomodulatory immunogenic agents immunizations, well their infectious diseases, allergies, suppression.
Language: Английский
Citations
11
Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1367 - 1367
Published: April 30, 2024
Carrageenan is a widely used food additive and seen as potential candidate in the pharmaceutical industry. However, there are two faces to carrageenan that allows it be positively for therapeutic purposes. can create edible films encapsulating drugs, also interest use of printing. naturally occurring polysaccharide gum. Depending on type carrageenan, regulating composition intestinal microflora, including increase population Bifidobacterium bacteria. On other hand, studies have demonstrated harmfulness animal human models, indicating direct link between diet inflammatory states. changes especially Akkermansia muciniphilia, degrades mucous barrier breaks down barrier, causing an reaction. It directly affects epithelial cells by activating pro-inflammatory nuclear factor kappa-light-chain-enhancer activated B (NF-kB) pathway. The mechanism based activation TLR4 receptor, alterations macrophage activity, production proinflammatory cytokines innate immune pathways. increases content Bacteroidetes bacteria, reduction number short chain fatty acid (SCFA)-producing result damage integrity membrane mucin layer. group most exposed harmful effects people suffering from inflammation, Crohn disease (CD) ulcerative colitis (UC).
Language: Английский
Citations
9
Life, Journal Year: 2023, Volume and Issue: 13(4), P. 1026 - 1026
Published: April 16, 2023
Inflammatory bowel disease (IBD) is a prominent global public health issue. Anti-inflammatory medications, immunosuppressants, and biological therapies are currently used as treatments. However, they often unsuccessful have negative consequences on human health. Thus, there tremendous demand for using natural substances, such seaweed polysaccharides, to treat IBD’s main pathologic treatment targets. The cell walls of marine algae rich in sulfated including carrageenan red algae, ulvan green fucoidan brown algae. These effective candidates drug development functional nutrition products. Algal polysaccharides IBD through therapeutic targets, inflammatory cytokines, adhesion molecules, intestinal epithelial cells, microflora. This study aimed systematically review the potential effects algal while providing theoretical basis nutritional preventive mechanism restoration results suggest that significant complementary therapy further research needed fully understanding their mechanisms action clinical applications.
Language: Английский
Citations
22