Hydrogel-Based Therapies for Ischemic and Hemorrhagic Stroke: A Comprehensive Review DOI Creative Commons
Alexandra Daniela Rotaru-Zavaleanu, Venera Cristina Dinescu,

Mădălina Aldea

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 476 - 476

Published: July 18, 2024

Stroke remains the second leading cause of death and a major disability worldwide, significantly impacting individuals, families, healthcare systems. This neurological emergency can be triggered by ischemic events, including small vessel arteriolosclerosis, cardioembolism, large artery atherothromboembolism, as well hemorrhagic incidents resulting from macrovascular lesions, venous sinus thrombosis, or vascular malformations, to significant neuronal damage. The resultant motor impairment, cognitive dysfunction, emotional disturbances underscore urgent need for effective therapeutic interventions. Recent advancements in biomaterials, particularly hydrogels, offer promising new avenues stroke management. Hydrogels, composed three-dimensional networks hydrophilic polymers, are notable their ability absorb retain substantial amounts water. Commonly used polymers hydrogel formulations include natural like alginate, chitosan, collagen, synthetic such polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyacrylamide. Their customizable characteristics—such porosity, swelling behavior, mechanical strength, degradation rates—make hydrogels ideal biomedical applications, drug delivery, cell tissue engineering, controlled release agents. review comprehensively explores hydrogel-based approaches both therapy, elucidating mechanisms which provide neuroprotection. It covers application delivery systems, role reducing inflammation secondary injury, potential support neurogenesis angiogenesis. also discusses current technology challenges translating these innovations research into clinical practice. Additionally, it emphasizes limited number trials utilizing therapies addresses associated limitations constraints, underscoring further this field.

Language: Английский

Photosensitive Hybrid γδ-T Exosomes for Targeted Cancer Photoimmunotherapy DOI Creative Commons
Yifan Gao, Jinzhao Liu,

Meicen Wu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Melanoma is the most aggressive type of skin cancers. Traditional chemotherapy and radiotherapy have limited effectiveness can lead to systemic side effects. Photodynamic therapy (PDT) a photoresponsive cancer based on photosensitizers generate reactive oxygen species (ROS) eradicate tumor cells. Our previous study showed that exosomes derived from human γδ-T cells (γδ-T exosomes) could control Epstein–Barr virus-associated tumors. Here, we combined PDT for targeted photoimmunotherapy by membrane fusion Chlorin e6 (Ce6)-loaded liposomes. The functional surface proteins, such as CCR5 PD-1, hybrid mediated specific binding toward melanoma tissues. cytolytic molecules, granzyme A, B, perforin, granulysin exosomes, induced apoptosis without harming normal In response light irradiation, ROS generation inside synergized with molecules induce promote immunogenic cell death (ICD). subsequently released damage-associated molecular patterns (DAMPs) stimulate dendritic maturation antigen-specific CD4+ CD8+ T-cell responses, thereby enhancing antitumor immunity. This provides promising strategy combining photoimmunotherapy, expanding clinical applications exosome patients.

Language: Английский

Citations

1
Expanding the role of exosomes in drug, biomolecule, and nanoparticle delivery DOI
Ongun Mehmet Saka, Devrim Demir Dora, Güneş Kibar

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: 368, P. 123499 - 123499

Published: Feb. 22, 2025

Language: Английский

Citations

1
Exosome isolation and characterization for advanced diagnostic and therapeutic applications DOI Creative Commons
Nobendu Mukerjee, Arghya Bhattacharya, Swastika Maitra

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101613 - 101613

Published: Feb. 25, 2025

Language: Английский

Citations

1
Exosomes derived from natural killer cells: transforming immunotherapy for aggressive breast cancer DOI
Abdulmalik Saleh Alfawaz Altamimi, M. Arockia Babu, Muhammad Afzal

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 18, 2025

Language: Английский

Citations

1
Current progress, strategy, and prospects of PD-1/PDL-1 immune checkpoint biosensing platforms for cancer diagnostics, therapy monitoring, and drug screening DOI Creative Commons
Katarzyna Ratajczak, Hubert Grel, Piotr Olejnik

et al.

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 240, P. 115644 - 115644

Published: Aug. 28, 2023

Recent technological advancements in testing and monitoring instrumentation have greatly contributed to the progress cancer treatment by surgical, chemotherapeutic radiotherapeutic interventions. However, mortality rate still remains high, calling for development of new strategies with higher efficacy. Extensive efforts driven this direction included broadening early screening applying innovative theranostic nanotechnologies. They been supported platforms introduced enable detection biomarkers, inhibitors, other agents, able slow down progression prevent metastasis. Despite well-recognized principles immune checkpoint blockade, efficacy immunotherapy achieved so far does not meet well-founded expectations. For a successful treatment, highly sensitive, robust, inexpensive multiplex biosensors be designed aid biomarkers inhibitors. In review, we provide an overview undertaken anticancer immunotherapy, based on programmed cell-death (PD-1/PDL-1) designing relevant their inhibitors screening. This review also emphasizes alternative targets made exosomes carrying PD-L1 overexpressed cells passed into excreted exosomes. Evaluated are novel targeted drug delivery nanocarriers, providing simultaneous biosensing, thereby contributing emerging therapy. On basis current trends technologies, future perspectives diagnostics using biosensing projected.

Language: Английский

Citations

18
EXOSOMES FOR SKIN TREATMENT: THERAPEUTIC AND COSMETIC APPLICATIONS DOI Creative Commons

Harsha Sreeraj,

R. AnuKiruthika,

K. S. Tamilselvi

et al.

Nano TransMed, Journal Year: 2024, Volume and Issue: unknown, P. 100048 - 100048

Published: Sept. 1, 2024

Language: Английский

Citations

8
Exosome-based drug delivery systems for enhanced neurological therapeutics DOI

Safa A Vahab,

K V Vyshma,

Vrinda S Kumar

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 15(4), P. 1121 - 1138

Published: Sept. 26, 2024

Language: Английский

Citations

8
Nanostructured Drug Delivery Systems in Immunotherapy: An Updated Overview of Nanotechnology-Based Therapeutic Innovations DOI Creative Commons

George-Alexandru Croitoru,

Adelina-Gabriela Niculescu,

Dragoș Epistatu

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(19), P. 8948 - 8948

Published: Oct. 4, 2024

Using nanostructured drug delivery systems has attracted increasing interest in immunotherapeutic approaches. The intrinsic immunomodulatory properties and versatility of nanoparticles used as carriers were consistently reported to augment treatment efficiency nanoscaled materials increase accumulation at the desired site, enhance cell internalization, improve therapeutic outcomes. Thus, numerous studies have exploited potential use vehicles delivering different cargo a promising alternative for treating conditions like cancer, autoimmune diseases, infectious allergic immune disorders. In this context, paper presents solid basis innovations, highlighting their advantages improving strategies, reviewing clinical applications, discussing existing challenges ways overcome them.

Language: Английский

Citations

8
Exosome-based immunotherapy as an innovative therapeutic approach in melanoma DOI Creative Commons

Shabnam Babaei,

Manouchehr Fadaee, Hajar Abbasi‐Kenarsari

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 31, 2024

The malignant form of melanoma is one the deadliest human cancers that accounts for almost all skin tumor-related fatalities in its later stages. Achieving an exhaustive understanding reliable cancer-specific markers and molecular pathways can provide numerous practical techniques direct way toward development rational curative medicines to increase lifespan patients. Immunotherapy has significantly enhanced treatment metastatic late-stage melanoma, resulting incredible positive responses therapy. Despite increasing occurrence median survival rate patients with advanced, inoperable terminal disease increased from around six months years. current knowledge tumor microenvironment (TME) interaction immune system resulted swift growth innovative immunotherapy treatments. Exosomes are small extracellular vesicles (EVs), ranging 30 150 nm size, majority cells released them. possess natural advantages such as high compatibility living organisms low potential causing reactions, making them delivering therapeutic agents like chemotherapy drugs, nucleic acids, proteins. This review highlights recent advancements using exosomes approach providing medications melanoma.

Language: Английский

Citations

6
Bio-Inspired Nanocarriers Derived from Stem Cells and Their Extracellular Vesicles for Targeted Drug Delivery DOI Creative Commons

Munire Abudurexiti,

Yue Zhao, Wang Xiao-ling

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 2011 - 2011

Published: July 24, 2023

With their seemingly limitless capacity for self-improvement, stem cells have a wide range of potential uses in the medical field. Stem-cell-secreted extracellular vesicles (EVs), as paracrine components cells, are natural nanoscale particles that transport variety biological molecules and facilitate cell-to-cell communication which been also widely used targeted drug delivery. These nanocarriers exhibit inherent advantages, such strong cell or tissue targeting low immunogenicity, synthetic lack. However, despite tremendous therapeutic EVs, further clinical application is still limited by yield lack standardized isolation purification protocols. In recent years, inspired concept biomimetics, new approach to biomimetic delivery has developed through combining nanotechnology bioengineering. This article reviews derived from EVs discusses advantages challenges order stimulate future research.

Language: Английский

Citations

14