Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
15(2), P. 436 - 454
Published: Aug. 5, 2024
One
of
the
advancements
transdermal
drug
delivery
system
(TDDS)
is
development
microneedles
(MNs).
These
micron-sized
needles
are
used
for
delivering
various
types
drugs
to
address
disadvantage
other
techniques
as
well
oral
systems.
MNs
have
high
patient
acceptance
due
self-administration
with
minimally
invasive
and
pain
compared
parenteral
delivery.
Over
years,
methods
been
adopted
evolve
make
them
more
cost-effective,
accurate,
suitable
multiple
applications.
such
method
3D
printing
MNs.
The
MN
platforms
using
has
made
possible
by
improved
features
like
precision,
resolution,
feasibility
low-cost
raw
materials.
In
this
review,
we
tried
explain
MNs,
fabrication
methods,
materials
in
formulation
recent
applications
that
utilize
3D-printed
Journal of Drug Delivery Science and Technology,
Journal Year:
2023,
Volume and Issue:
89, P. 105087 - 105087
Published: Oct. 19, 2023
Skin
plays
an
essential
role
in
our
personal
image
and
aesthetics
as
it
is
where
the
first
signs
of
aging
are
visible.
As
a
way
to
prevent
mitigate
this
natural
physiological
process
achieve
more
youthful
appearance,
consumers
constantly
looking
for
innovative
options
anti-aging
skincare
products,
including
effective
safer
ingredients.
Particularly,
peptides
cosmetic
ingredients
present
formulations
attending
their
efficacy
reducing
wrinkles
hyperpigmentation,
and/or
stimulating
collagen
production.
Moreover,
less
irritating
alternatives
regarding
conventional
against
skin
aging.
However,
despite
these
advantages,
have
considerable
difficulty
penetrate
stratum
corneum,
which
hinders
bioactivity.
This
occurs
high
molecular
weight,
hydrophilic
character,
susceptibility
enzymatic
degradation,
requiring
application
formulation
technologies
improve
stability
release
pattern
through
skin.
A
detailed
exposition
focused
on
smart
multifunctional
nanodelivery
systems
that
been
used
encapsulate
provided,
within
scope
research
development
products.
Briefly,
demonstrated
biomolecules
reliable
outstanding
alternative
considering
retinoids
sunscreens
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(7)
Published: Nov. 27, 2023
Abstract
Skin‐mediated
drug
delivery
methods
currently
are
receiving
significant
attention
as
a
promising
approach
for
the
enhanced
of
drugs
through
skin.
offers
potential
to
overcome
limitations
traditional
methods,
including
oral
administration
and
intravenous
injection.
The
challenges
associated
with
permeation
layers
skin,
which
act
major
barrier,
explored,
strategies
these
discussed
in
detail.
This
review
categorizes
skin‐mediated
based
on
means
increasing
permeation,
it
provides
comprehensive
overview
mechanisms
techniques
methods.
In
addition,
recent
advancements
application
presented.
also
outlines
ongoing
research
suggests
future
perspectives
studies
regarding
drugs.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: April 4, 2024
Abstract
The
underlying
study
was
carried
out
aiming
at
transdermal
drug
delivery
(TDD)
of
Goniothalamus
macrophyllus
as
sono-photo-sensitizer
(SPS)
using
microneedle
(MN)
arrays
with
iontophoresis
(MN-IP),
electroporation
(MN-EP)
in
conjunction
applying
photodynamic
therapy
(PDT),
sonodynamic
(SDT)
and
sono-photodynamic
(SPDT)
an
up-to-date
activated
cancer
treatment
modality.
Study
conducted
on
120
male
Swiss
Albino
mice,
inoculated
Ehrlich
ascites
carcinoma
(EAC)
divided
into
9
groups.
We
employed
three
different
MN
electrodes
were
used
(parallel,
triangular,
circular),
EP,
IP
volts
(6,
9,
12
V),
infrared
laser
ultrasound
(pulsed
continuous
wave)
our
two
energy
sources.
Results
revealed
that
parallel
6
V
TDD@MN@IP@EP
can
be
effective
system
for
G.
from
skin
directly
to
target
EAC
cells.
In
addition
MN@IP@EP@TDD
is
a
potential
SPS
SPDT
EAC.
With
respect
normal
control
mice
opposed
the
untreated
MN@EP@IP
TDD
laser,
ultrasound,
combination
groups
showed
significant
increase
antioxidant
markers
TAC
level
GST,
GR,
Catalase,
SOD
activities,
while
decrease
lipid
peroxidation
oxidative
stress
parameter
MDA
levels.
significantly
increased
apoptotic
genes
expressions
(p53,
caspase
(3,
9),
Bax,
TNF
alpha)
other
hand
decreased
anti-
(Bcl-2)
angiogenic
(VEGF)
expressions.
Moreover
ameliorate
liver
kidney
function
decreasing
ALT,
AST,
urea
creatinine
respectively.
Furthermore
combined
very
reducing
growth
tumors
even
causing
cell
death
according
microscopic
H&E
stain
results.
This
process
may
related
sono-
and/or
photochemical
activation
mechanism.
According
findings,
has
lot
novel,
efficient
method
demonstrated
promising
anticancer
impact
treating
cancer.
Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
15(2), P. 436 - 454
Published: Aug. 5, 2024
One
of
the
advancements
transdermal
drug
delivery
system
(TDDS)
is
development
microneedles
(MNs).
These
micron-sized
needles
are
used
for
delivering
various
types
drugs
to
address
disadvantage
other
techniques
as
well
oral
systems.
MNs
have
high
patient
acceptance
due
self-administration
with
minimally
invasive
and
pain
compared
parenteral
delivery.
Over
years,
methods
been
adopted
evolve
make
them
more
cost-effective,
accurate,
suitable
multiple
applications.
such
method
3D
printing
MNs.
The
MN
platforms
using
has
made
possible
by
improved
features
like
precision,
resolution,
feasibility
low-cost
raw
materials.
In
this
review,
we
tried
explain
MNs,
fabrication
methods,
materials
in
formulation
recent
applications
that
utilize
3D-printed
