Clinical translation of nanomedicines: Challenges, opportunities, and keys

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 181, P. 114083 - 114083

Published: Dec. 17, 2021

Language: Английский

---

Nanoparticles in Clinical Translation for Cancer Therapy

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1685 - 1685

Published: Feb. 1, 2022

The advent of cancer therapeutics brought a paradigm shift from conventional therapy to precision medicine. new therapeutic modalities accomplished through the properties nanomaterials have extended their scope in beyond drug delivery. Nanoparticles can be channeled encapsulate active pharmaceutical ingredients and deliver them tumor site more efficient manner. This review enumerates various types nanoparticles that entered clinical trials for treatment. obstacles journey nanodrug clinic market are reviewed. Furthermore, latest developments using also highlighted.

Language: Английский

---

Nanomedicine-based commercial formulations: current developments and future prospects

Journal of Pharmaceutical Investigation, Journal Year: 2022, Volume and Issue: 53(1), P. 19 - 33

Published: Dec. 19, 2022

Language: Английский

---

Review of Antimicrobial Nanocoatings in Medicine and Dentistry: Mechanisms of Action, Biocompatibility Performance, Safety, and Benefits Compared to Antibiotics

ACS Nano, Journal Year: 2023, Volume and Issue: 17(8), P. 7064 - 7092

Published: April 7, 2023

This review discusses topics relevant to the development of antimicrobial nanocoatings and nanoscale surface modifications for medical dental applications. Nanomaterials have unique properties compared their micro- macro-scale counterparts can be used reduce or inhibit bacterial growth, colonization biofilm development. Generally, exert effects through biochemical reactions, production reactive oxygen species ionic release, while modified nanotopographies create a physically hostile bacteria, killing cells via biomechanical damage. Nanocoatings may consist metal nanoparticles including silver, copper, gold, zinc, titanium, aluminum, nonmetallic compounds in carbon-based form graphene carbon nanotubes, composed silica chitosan. Surface nanotopography by inclusion nanoprotrusions black silicon. Two more nanomaterials combined nanocomposites with distinct chemical physical characteristics, allowing combination different such as activity, biocompatibility, strength, durability. Despite wide range applications engineering, questions been raised regarding potential toxicity hazards. Current legal frameworks do not effectively regulate matters safety, open remaining about risk analysis occupational exposure limits considering coating-based approaches. Bacterial resistance is also concern, especially where it affect wider resistance. excellent future use, but safe antimicrobials requires careful consideration "One Health" agenda, appropriate legislation, assessment.

Language: Английский

---

Biosafety of mesoporous silica nanoparticles; towards clinical translation

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 201, P. 115049 - 115049

Published: Aug. 12, 2023

Mesoporous silica nanoparticles (MSNs) have attracted the attention of chemists, who developed numerous systems for encapsulation a plethora molecules, allowing use mesoporous biomedical applications. MSNs been extensively studied their in nanomedicine, applications such as drug delivery, diagnosis, and bioimaging, demonstrating significant vivo efficacy different preclinical models. Nevertheless, transition into clinical trials, it is imperative to understand characteristics that make effective safe. The biosafety properties are greatly influenced by physicochemical particle shape, size, surface modification, framework. In this review, we compile most relevant recent progress literature up present analyzing contributions on biodistribution, biodegradability, clearance MSNs. Furthermore, ongoing trials potential challenges related administration materials advanced therapeutics discussed. This approach aims provide solid overview state-of-the-art field encourage translation clinic.

Language: Английский

---

MACHINE LEARNING IN DRUG DISCOVERY: A CRITICAL REVIEW OF APPLICATIONS AND CHALLENGES

Computer Science & IT Research Journal, Journal Year: 2024, Volume and Issue: 5(4), P. 892 - 902

Published: April 17, 2024

This review critically examines the integration of Machine Learning (ML) in drug discovery, highlighting its applications across target identification, hit lead optimization, and predictive toxicology. Despite ML's potential to revolutionize discovery through enhanced efficiency, accuracy, novel insights, significant challenges persist. These include issues related data quality, model interpretability, into existing workflows, regulatory ethical considerations. The advocates for advancements algorithmic approaches, interdisciplinary collaboration, improved data-sharing practices, evolving frameworks as solutions these challenges. By addressing hurdles leveraging capabilities ML, process can be significantly accelerated, paving way development new therapeutics. calls continued research, dialogue among stakeholders realize transformative ML fully. Keywords: Learning, Drug Discovery, Predictive Toxicology, Data Quality, Interdisciplinary Collaboration.

Language: Английский

---

Cancer Nanovaccines: Nanomaterials and Clinical Perspectives

Small, Journal Year: 2024, Volume and Issue: 20(35)

Published: May 1, 2024

Abstract Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art nanovaccine development, elucidating innovative strategies and technologies employed their design. It explores both preclinical clinical advancements, emphasizing key studies demonstrating potential elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, impact of nanoscale properties on performance. Detailed insights into complex interplay between tumor microenvironment responses are provided, highlighting challenges opportunities optimizing therapeutic outcomes. Additionally, presents thorough analysis ongoing trials, presenting snapshot landscape. By curating latest scientific findings developments, this aims serve as comprehensive resource researchers clinicians engaged advancing immunotherapy. Integrating design holds immense promise revolutionizing treatment paradigms, provides timely update evolving landscape nanovaccines.

Language: Английский

---

Mesoporous silica nanotechnology: promising advances in augmenting cancer theranostics

Cancer Nanotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 31, 2024

Abstract Owing to unique facets, such as large surface area, tunable synthesis parameters, and ease of functionalization, mesoporous silica nanoparticles (MSNs) have transpired a worthwhile platform for cancer theranostics over the last decade. The full potential MSNs in theranostics, however, is yet be realized. While can employed targeted drug delivery imaging, their effectiveness frequently hindered by factors, biological barriers, complex tumor microenvironment, target non-specificity ineffectiveness individual functionalized moieties. primary purpose this review highlight technological advances tumor-specific, stimuli-responsive “smart” multimodal MSN-based hybrid nanoplatforms that overcome these limitations improve MSN theranostics. This article offers an extensive overview technology outlining key directions future research well challenges are involved aspect. We aim underline vitality relevance current advancements field potentially enhance clinical outcomes through provision more precise focused theranostic approaches.

Language: Английский

---

Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(10), P. 2845 - 2916

Published: July 13, 2024

Abstract Several efforts have been extensively accomplished for the amelioration of cancer treatments using different types new drugs and less invasives therapies in comparison with traditional therapeutic modalities, which are widely associated numerous drawbacks, such as drug resistance, non-selectivity high costs, restraining their clinical response. The application natural compounds prevention treatment cells has attracted significant attention from pharmaceuticals scientific communities over past decades. Although use nanotechnology therapy is still preliminary stages, nanotherapeutics demonstrated to decrease various limitations related compounds, physical/chemical instability, poor aqueous solubility, low bioavailability. Despite emerged a promise improve bioavailability there limited trials performed challenges required pre-clinical trials, production at an industrial level, assurance long-term stability, physiological barriers safety regulatory issues. This review highlights most recent advances nanocarriers secreted plants, bacteria, fungi, marine organisms, well role on cell signaling pathways anticancer treatments. Additionally, status main regarding loaded applications were also discussed. Graphical abstract

Language: Английский

---

SERS in 3D cell models: a powerful tool in cancer research

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(10), P. 5118 - 5148

Published: Jan. 1, 2024

3D cancer models recapitulate the tumor microenvironment and serve as a platform to study cell behavior, drug discovery early diagnosis, which can be monitored chemically with subcellular resolution in real time, via SERS.

Language: Английский

---