Emerging Applications of Nanotechnology in Healthcare and Medicine

Molecules, Journal Year: 2023, Volume and Issue: 28(18), P. 6624 - 6624

Published: Sept. 14, 2023

Knowing the beneficial aspects of nanomedicine, scientists are trying to harness applications nanotechnology in diagnosis, treatment, and prevention diseases. There also potential uses designing medical tools processes for new generation scientists. The main objective conducting this research review is gather widespread nanomedicine under one heading highlight standard practices field. Comprehensive has been conducted incorporate latest data related medicine therapeutics derived from acknowledged scientific platforms. Nanotechnology used conduct sensitive procedures. showing successful fields diagnostics, disease regenerative medicine, gene therapy, dentistry, oncology, aesthetics industry, drug delivery, therapeutics. A thorough association cooperation between physicians, clinicians, researchers, technologies will bring forward a future where there more calculated, outlined, technically programed field nanomedicine. Advances being made overcome challenges associated with application due pathophysiological basis This highlights multipronged how proving health industry. need minimize health, environmental, ethical concerns linked nanotechnology.

Language: Английский

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Multifunctional nanoparticle-mediated combining therapy for human diseases

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 1, 2024

Abstract Combining existing drug therapy is essential in developing new therapeutic agents disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established treating extensive human diseases. Attributed to synergistic effects by targeting various pathways advantages, such as reduced administration dose, decreased toxicity, alleviated resistance, combinatorial treatment now being pursued delivering combat major clinical illnesses, cancer, atherosclerosis, pulmonary hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, metabolic disorders neurodegenerative Combinatorial involves combining or co-delivering two more for a specific disease. Nanoparticle (NP)-mediated delivery systems, i.e., liposomal NPs, polymeric NPs nanocrystals, are great interest wide range due targeted delivery, extended release, higher stability avoid rapid clearance at infected areas. This review summarizes targets diseases, clinically approved combinations the development multifunctional emphasizes strategies based on severe Ultimately, we discuss challenging NP-codelivery translation provide potential approaches address limitations. offers comprehensive overview recent cutting-edge NP-mediated combination

Language: Английский

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Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges

Molecules, Journal Year: 2023, Volume and Issue: 28(18), P. 6687 - 6687

Published: Sept. 18, 2023

Nanotechnology has ushered in a new era of medical innovation, offering unique solutions to longstanding healthcare challenges. Among nanomaterials, copper and oxide nanoparticles stand out as promising candidates for multitude applications. This article aims provide contemporary insights into the perspectives challenges regarding use medicine. It summarises biomedical potential copper-based nanoformulations, including progress early-stage research, evaluate mitigate toxicity nanomaterials. The discussion covers prospects nanomaterials context their successful clinical translation. also addresses safety concerns, emphasizing need assessments nanomedicines. However, attention is needed solve current such biocompatibility controlled release. Ongoing research collaborative efforts overcome these obstacles are discussed. analysis guidance safe effective integration practice, thereby advancing recent literature highlighted multifaceted associated with translation from laboratory clinic. In particular, remains formidable hurdle, requiring innovative ensure seamless human body. Additionally, achieving release therapeutic agents poses complex challenge that requires meticulous engineering precise design.

Language: Английский

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Mesoporous Silica Nanoparticles as a Potential Nanoplatform: Therapeutic Applications and Considerations

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6349 - 6349

Published: March 28, 2023

With advances in nanotechnology, nanoparticles have come to be regarded as carriers of therapeutic agents and been widely studied overcome various diseases the biomedical field. Among these particles, mesoporous silica (MSNs) investigated potential nanocarriers deliver drug molecules target sites body. This review introduces physicochemical properties MSNs synthesis procedures MSN-based nanoplatforms. Moreover, we focus on updating applications a carrier or diagnostic cargo clinical trials using silica-nanoparticle-based systems. Herein, one hand, pay attention pharmaceutical advantages MSNs, including nanometer particle size, high surface area, porous structures, thus enabling efficient delivery drug-loading content. On other look through biosafety toxicity issues associated with platforms. Based many reports so far, applied construct tissue engineering platforms well treat diseases, cancer, by functionalization incorporation stimuli-responsive components. However, even advantageous aspects that possess, there are still considerations, such optimizing dosage regimens, regarding use clinics. Progress scale-up production thorough investigation into would enable design innovative safe fields.

Language: Английский

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Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Discover Nano, Journal Year: 2023, Volume and Issue: 18(1)

Published: Dec. 19, 2023

The nanosystems for delivering drugs which have evolved with time, are being designed greater drug efficiency and lesser side-effects, also complemented by the advancement of numerous innovative materials. In comparison to organic nanoparticles, inorganic nanoparticles stable, a wide range physicochemical, mechanical, magnetic, optical characteristics, capability get modified using some ligands enrich their attraction towards molecules at target site, makes them appealing bio-imaging delivery applications. One strong benefits nanoparticles-drug conjugate is possibility affected cells locally, thus reducing side-effects like cytotoxicity, facilitating higher efficacy therapeutic drug. This review features direct indirect effects such gold, silver, graphene-based, hydroxyapatite, iron oxide, ZnO, CeO2 in developing effective carrier systems. article has remarked peculiarities these nanoparticle-based systems pulmonary, ocular, wound healing, antibacterial deliveries as well across Blood-Brain-Barrier (BBB) acting agents cancer theranostics. Additionally, sheds light on plausible modifications that can be carried out from researcher's perspective, could open new pathway.

Language: Английский

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Nanotechnology in healthcare, and its safety and environmental risks

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 15, 2024

Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract

Language: Английский

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Recent Advances in Intranasal Administration for Brain-Targeting Delivery: A Comprehensive Review of Lipid-Based Nanoparticles and Stimuli-Responsive Gel Formulations

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1767 - 1807

Published: Feb. 1, 2024

Abstract: Addressing disorders related to the central nervous system (CNS) remains a complex challenge because of presence blood-brain barrier (BBB), which restricts entry external substances into brain tissue. Consequently, finding ways overcome limited therapeutic effect imposed by BBB has become goal in advancing delivery systems targeted brain. In this context, intranasal route emerged as promising solution for delivering treatments directly from nose through olfactory and trigeminal nerve pathways thus, bypassing BBB. The use lipid-based nanoparticles, including nano/microemulsions, liposomes, solid lipid nanostructured carriers, shown promise enhancing efficiency nose-to-brain delivery. These nanoparticles facilitate drug absorption nasal membrane. Additionally, situ gel (ISG) gained attention owing its ability extend retention time administered formulations within cavity. When combined with ISG creates synergistic effect, further overall effectiveness brain-targeted strategies. This comprehensive review provides thorough investigation administration. It delves strengths limitations specific considering anatomical complexities influential factors that play role during dosing. Furthermore, study introduces strategic approaches incorporating framework applications. Finally, recent information on approved products clinical trial status administration, along inclusion quality-by-design–related insights. Keywords: system, based nanoparticle, gel,

Language: Английский

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Cancer Nanovaccines: Nanomaterials and Clinical Perspectives

Small, Journal Year: 2024, Volume and Issue: 20(35)

Published: May 1, 2024

Abstract Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art nanovaccine development, elucidating innovative strategies and technologies employed their design. It explores both preclinical clinical advancements, emphasizing key studies demonstrating potential elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, impact of nanoscale properties on performance. Detailed insights into complex interplay between tumor microenvironment responses are provided, highlighting challenges opportunities optimizing therapeutic outcomes. Additionally, presents thorough analysis ongoing trials, presenting snapshot landscape. By curating latest scientific findings developments, this aims serve as comprehensive resource researchers clinicians engaged advancing immunotherapy. Integrating design holds immense promise revolutionizing treatment paradigms, provides timely update evolving landscape nanovaccines.

Language: Английский

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Mesoporous silica nanotechnology: promising advances in augmenting cancer theranostics

Cancer Nanotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 31, 2024

Abstract Owing to unique facets, such as large surface area, tunable synthesis parameters, and ease of functionalization, mesoporous silica nanoparticles (MSNs) have transpired a worthwhile platform for cancer theranostics over the last decade. The full potential MSNs in theranostics, however, is yet be realized. While can employed targeted drug delivery imaging, their effectiveness frequently hindered by factors, biological barriers, complex tumor microenvironment, target non-specificity ineffectiveness individual functionalized moieties. primary purpose this review highlight technological advances tumor-specific, stimuli-responsive “smart” multimodal MSN-based hybrid nanoplatforms that overcome these limitations improve MSN theranostics. This article offers an extensive overview technology outlining key directions future research well challenges are involved aspect. We aim underline vitality relevance current advancements field potentially enhance clinical outcomes through provision more precise focused theranostic approaches.

Language: Английский

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Nanomaterials in Drug Delivery: Strengths and Opportunities in Medicine

Molecules, Journal Year: 2024, Volume and Issue: 29(11), P. 2584 - 2584

Published: May 31, 2024

There is a myriad of diseases that plague the world ranging from infectious, cancer and other chronic with varying interventions. However, dynamism causative agents infectious incessant mutations accompanying forms like cancer, have worsened treatment outcomes. These factors often lead to failure via different drug resistance mechanisms. More so, cost developing newer drugs huge. This underscores need for paradigm shift in delivery approach order achieve desired intensified research nanomedicine, which has shown promises improving therapeutic outcome at preclinical stages increased efficacy reduced toxicity. Regardless huge benefits nanotechnology delivery, challenges such as regulatory approval, scalability, implication potential toxicity must be addressed streamlining hurdles funding. In conclusion, idea holds immense promise optimizing work presents opportunities revolutionize strategies, providing expert opinions on translating amount nanomedicine into clinical patients resistant infections cancer.

Language: Английский

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