Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 5122 - 5122
Published: Oct. 30, 2024
Emodin (EMO) is an anthraquinone compound derived from
Language: Английский
Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1000 - 1000
Published: Feb. 25, 2024
Quercetin is a flavonoid with low molecular weight that belongs to the human diet’s phenolic phytochemicals and nonenergy constituents. has potent antioxidant capacity, being able capture reactive oxygen species (ROS), nitrogen (RNS), chlorine (ROC), which act as reducing agents by chelating transition-metal ions. Its structure five functional hydroxyl groups, work electron donors are responsible for capturing free radicals. In addition its different pharmacological properties of quercetin have been described, such carcinostatic properties; antiviral, antihypertensive, anti-inflammatory ability protect low-density lipoprotein (LDL) oxidation, inhibit angiogenesis; these developed in this review.
Language: Английский
Citations
59
Published: Feb. 2, 2024
Quercetin is a flavonoid with low molecular weight that belongs to the human diet's phenolic phytochemicals and non-energy constituents. has potent antioxidant capacity, being able capture Reactive Oxygen Species (ROS), reactive nitro-gen species (RNS), Chlorine (ROC), which act as reducing agents by chelating transition metal ions. Its structure five functional hydroxyl groups, work electron donors are responsible for capturing free radicals. In addition its it was described different pharmacological properties of Quercetin, such carcinostatic properties, antiviral, antihypertensive, anti-inflammatory, protection Low-Density Lipoprotein (LDL) oxidation, inhibi-tion angiogenesis developed in this review.
Language: Английский
Citations
22
Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)
Published: March 7, 2024
Abstract Breast cancer is a complex and heterogeneous disease, encompassing various subtypes characterized by distinct molecular features, clinical behaviors, treatment responses. Categorization of based on the presence or absence estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2), leading to such as luminal A, B, HER2-positive, triple-negative breast (TNBC). TNBC, comprising around 20% all cancers, lacks expression ER, PR, HER2 receptors, rendering it unresponsive targeted therapies presenting significant challenges in treatment. TNBC associated with aggressive behavior, high rates recurrence, resistance chemotherapy. Tumor initiation, progression, are attributed stem cells (BCSCs), which possess self-renewal, differentiation, tumorigenic potential. Surface markers, self-renewal pathways (Notch, Wnt, Hedgehog signaling), apoptotic protein (Bcl-2), angiogenesis inhibition (VEGF inhibitors), immune modulation (cytokines, checkpoint inhibitors) among key targets discussed this review. However, targeting BCSC subpopulation presents challenges, including off-target effects, low solubility, bioavailability anti-BCSC agents. Nanoparticle-based offer promising approach target cellular processes implicated survival BSCS TNBC. In review, we explore nanocarrier-based approaches for BCSCs aiming overcome these improve outcomes patients. These nanoparticle-based therapeutic strategies hold promise addressing gap delivering while minimizing systemic toxicity enhancing efficacy. Graphical abstract
Language: Английский
Citations
17
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160172 - 160172
Published: Feb. 1, 2025
Language: Английский
Citations
1
Published: Aug. 27, 2024
The increasing occurrence of chronic metabolic diseases (CMDs) presents a substantial public health challenge worldwide, necessitating the development pioneering therapeutic approaches. Flavonoids, which are naturally occurring compounds, exert broad spectrum biological activities, encompassing their anti-inflammatory, anti-diabetic, and antioxidant properties, among others. Though they have potential role in treating CMDs, face challenges extraction purification, poor gastrointestinal absorption, low solubility, rapid metabolism, impede clinical applicability. Nanotherapeutics has been receiving significant attention as it aids resolving these issues. Hence, purpose this chapter is to shed light on advances different nanoengineered formulations flavonoids. commences with an outline diseases, emphasizing prevalence pressing need for innovative therapeutics strategies address burden. Following this, flavonoids conditions discussed. Moreover, also elucidates nanoengineering accomplishing efficient flavonoid delivery, particular emphasis versatile nanoformulations, such liposomes, solid lipid nanoparticles, phytosomes. Next, we discuss optimization techniques, surface modification enhance targeting stability, controlled release approaches sustained effects, synergistic outcomes. enhancement bioavailability stability addressed, overcome barriers, targeted delivery site-specific action, methods prevent degradation. Subsequent sections elucidate managing focusing obesity, diabetes, cardiovascular disorders. mechanisms action impact systems efficacy highlighted, providing valuable insights. It highlights involved applicability discusses issues."
Language: Английский
Citations
5
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)
Published: March 18, 2025
Language: Английский
Citations
0
Medical Hypotheses, Journal Year: 2025, Volume and Issue: unknown, P. 111644 - 111644
Published: May 1, 2025
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: May 12, 2025
Abstract Autophagy plays a crucial role in tumor drug resistance by enabling cancer cells to survive under stress conditions, including chemotherapy. It helps maintain homeostasis, resist cell death, and contribute therapy failure. This study analyzed the literature related autophagy based on Web of Science Core Collection (WoSCC) database. The results revealed that there are 9284 relevant articles published date, covering 103 countries regions, with contributions from 5964 institutions 37,240 researchers. annual number publications has steadily increased since 2004, especially after 2019, indicating growing importance research. China leads globally terms publication output, accounting for nearly 50% total publications. Additionally, international collaboration cross-country research have become increasingly prominent, particularly collaborations between like South Korea Japan. Journal analysis showed International Molecular Sciences Oncotarget most productive journals, while stands out higher impact factor. Author, citation, keyword analyses hotspots future trends field resistance, chemotherapy death mechanisms, immunotherapy. provides systematic academic perspective emphasizes strengthening cooperation.
Language: Английский
Citations
0
AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(5)
Published: May 16, 2025
Language: Английский
Citations
0
Published: Jan. 18, 2024
In the present study, hypereutectic Al-Si alloy compacts and Al-Si/B4C composites were produced by conventional, microwave spark plasma sintering techniques. The effects of techniques B4C particle addition on microstructural properties, density, hardness electrical conductivity investigated. microstructures examined with an optical microscope. Densities measured using Archimedes technique. Electrical resistance measurements made four-point probe measurement Elemental Al grains, master grains primary Si particles determined in all samples. 15 wt% caused porosity rate to increase Samples SPS technique gave ≈80% higher values than samples CS MWS. Compared MWS, values. conductivities decreased as weight percentage increased
Language: Английский
Citations
0