Azole Derivatives: Cutting‐Edge Agents in Cancer Therapy DOI

Anuradha Mehra,

Amit Mittal, Rekha Sangwan

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(43)

Published: Nov. 1, 2024

Abstract Monocyclic 5‐membered heterocycles including imidazoles, thiazoles, oxazoles, and their related compounds have gained significant attention in medicinal chemistry because of potent anticancerous activity. These small heterocyclic molecules possess versatile properties, biological activity, absorption, distribution, metabolism, excretion, chemical diversity that give them immense potential as anticancer agents. It is also a fact inherent characteristic azoles to combine with many through hydrogen bond, stacking, hydrophobic interaction makes effective against almost all cancer types. In the present paper author discusses way which connected structure monocyclic activity namely ability these intercalate DNA, inhibit some enzymes interfere cellular signaling pathways. Interestingly, several azole derivatives been seen be preclinical efficacy studies well clinical trials are considered overcoming problem resistance side effects common As synthetic progresses, structural system has diversified development pharmacology become more specific. This helped enhancing formation new class improved selectivity efficacy. Furthermore, comprehensive review explains how computational structure‐activity relationship (SAR) approaches applied design future‐generation compounds. light facts, this article designed broad overview current state azole‐based agents an attempt further assert its therapeutic promise spur attempts at infusing said into therapeutics fray. The discoveries made study may allow radical different approaches, could lead targeted treatment cancer.

Language: Английский

Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review DOI Creative Commons

Dana M. Odeh,

Mohanad Odeh,

Taghrid S. Hafez

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 366 - 366

Published: Jan. 17, 2025

Heterocyclic compounds, especially those containing the pyrazole moiety, are highly significant in organic chemistry and possess remarkable diverse biological properties. The 5-aminopyrazole derivatives key starting materials for synthesis of numerous bioactive compounds such as pyrazolopyridine, pyrazolopyrimidine, pyrazoloquinazoline, pyrazolotriazine derivatives. Many inspired by a wide spectrum activities medicinal applications antioxidants, anticancer agents, enzyme inhibitors, antimicrobials, anti-tuberculosis activities. This review summarizes recently reported methods fused pyrazole-based based on within last 5 years (2020 to present). One important goals this is illustrate future strategies design, development, utilization products potent drugs.

Language: Английский

Citations

1
Emerging synthetic Strategies and Pharmacological Insights of 1,3,4-Thiadiazole Derivatives: A Comprehensive Review DOI

Davinder Kumar,

Navidha Aggarwal,

Virender Kumar

et al.

Future Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 16(6), P. 563 - 581

Published: Feb. 14, 2024

This review meticulously examines the synthesis techniques for 1,3,4-thiadiazole derivatives, focusing on cyclization, condensation reactions and functional group transformations. It enhances understanding of these chemical methods that re crucial tailoring derivative properties functionalities. study is considered to be vital researchers, detailing established effects such as antioxidant, antimicrobial anticancer activities, revealing emerging pharmacological potentials neuroprotective, antiviral antidiabetic properties. also discusses molecular mechanisms underlying effects. In addition, this article covers structure–activity relationship studies computational modelling are essential designing potent, selective compounds. work lays a foundation future research targeted therapeutic development.

Language: Английский

Citations

4
Molecular modeling and antimicrobial activity of newly synthesized benzothiazole-thiazole conjugates DOI
Arwa Alharbi,

Mansoor Alsahag,

Ali Alisaac

et al.

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2024, Volume and Issue: 456, P. 115852 - 115852

Published: June 22, 2024

Language: Английский

Citations

2
Azole Derivatives: Cutting‐Edge Agents in Cancer Therapy DOI

Anuradha Mehra,

Amit Mittal, Rekha Sangwan

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(43)

Published: Nov. 1, 2024

Abstract Monocyclic 5‐membered heterocycles including imidazoles, thiazoles, oxazoles, and their related compounds have gained significant attention in medicinal chemistry because of potent anticancerous activity. These small heterocyclic molecules possess versatile properties, biological activity, absorption, distribution, metabolism, excretion, chemical diversity that give them immense potential as anticancer agents. It is also a fact inherent characteristic azoles to combine with many through hydrogen bond, stacking, hydrophobic interaction makes effective against almost all cancer types. In the present paper author discusses way which connected structure monocyclic activity namely ability these intercalate DNA, inhibit some enzymes interfere cellular signaling pathways. Interestingly, several azole derivatives been seen be preclinical efficacy studies well clinical trials are considered overcoming problem resistance side effects common As synthetic progresses, structural system has diversified development pharmacology become more specific. This helped enhancing formation new class improved selectivity efficacy. Furthermore, comprehensive review explains how computational structure‐activity relationship (SAR) approaches applied design future‐generation compounds. light facts, this article designed broad overview current state azole‐based agents an attempt further assert its therapeutic promise spur attempts at infusing said into therapeutics fray. The discoveries made study may allow radical different approaches, could lead targeted treatment cancer.

Language: Английский

Citations

2