The Inflammatory Axis of LncRNA Ftx/miR-382-5p/NRG1 in the Differential Diagnosis and Prognosis of Multiple Sclerosis and Neuromyelitis Optica

Inflammation, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Multiple sclerosis (MS) and Neuromyelitis Optica (NMO) are immune-related CNS inflammatory diseases that often present with overlapping clinical symptoms, leading to frequent misdiagnosis, particularly in aquaporin-4 seronegative NMO patients. Identifying the underlying mechanisms of these is critical for discovering biomarkers enable timely diagnosis effective treatment. This study included 252 participants, divided into four groups. Group I (Relapsing–Remitting MS: RRMS group), II (Secondary Progressive SPMS III (NMO IV (Healthy controls). Blood samples were collected from all participants measure expression levels Neuregulin-1 (NRG1), lncRNA Ftx, miR-382-5p . The results showed NRG1 significantly lower RRMS, SPMS, groups compared healthy controls, most pronounced reduction observed NMO, suggesting may serve as a potential biomarker differentiating MS, especially cases where traditional diagnostic criteria inconclusive. Ftx , sponge exhibited an opposite trend was downregulated its promising biomarker. Our findings highlight NRG1, diagnostic, screening, prognostic biomarkers, well tools differential MS. Graphical

Language: Английский

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Reassessing the Role of Tissue Factor Pathway Inhibitor 2 in Neoplastic and Non-Neoplastic Lesions

Cancers, Journal Year: 2025, Volume and Issue: 17(9), P. 1447 - 1447

Published: April 25, 2025

Objectives: Tissue factor pathway inhibitor 2 (TFPI2) is a serine protease that suppresses tumors by preventing extracellular matrix degradation and invasion. In many malignancies, the TFPI2 promoter hypermethylation silences its transcription, increasing tumor aggressiveness. However, paradoxically facilitates progression in certain malignancies. Elevated circulating levels correlate with increased cancer aggressiveness poor prognosis ovarian, endometrial, renal cell carcinoma, though mechanisms underlying tumor-promoting effects remain unclear. This review consolidates recent findings on regulation, downstream targets cellular homeostasis, prognostic significance. Additionally, we reassess TFPI2′s role tumorigenesis, particularly clear as well chronic inflammation. Methods: A comprehensive literature search was performed PubMed Google Scholar without time restriction. Results: expression tightly regulated transcription factors, signaling molecules, growth cytokines, epigenetic modification. regulates proliferation, inflammation, (ECM) remodeling, preserving tissue homeostasis. also vascular endothelial smooth muscle key elements of microenvironment (TME). nucleus, it may modulate factors to influence tumor-associated macrophage (TAM) polarization, facilitating Its be shaped interactions between cells TAM activation. Beyond contributes both inflammatory resolution diabetes, atherosclerosis, preeclampsia. Conclusions: interact TAMs regulate proliferation maintaining

Language: Английский

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MicroRNA-593-3p Inhibits Growth and Metastasis of Human Breast Cancer Cells by Regulating TIMM17A Expression

Biochemical Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

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The emerging role of non-coding RNAs in the Wnt/β-catenin signaling pathway in Prostate Cancer

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155134 - 155134

Published: Jan. 14, 2024

Language: Английский

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Unlocking the role of non-coding RNAs in prostate cancer progression: exploring the interplay with the Wnt signaling pathway

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 27, 2023

Prostate cancer (PCa) is one of the most common cancers in males, exhibiting a wide spectrum clinical manifestations that pose challenges its diagnosis and treatment. The Wnt signaling pathway, conserved complex crucial for embryonic development, tissue homeostasis, various physiological processes. Apart from classical Wnt/β-catenin there exist multiple non-classical pathways, including Wnt/PCP Wnt/Ca 2+ pathways. Non-coding RNAs (ncRNAs) are involved occurrence development PCa response to ncRNAs known execute diverse regulatory roles cellular processes, despite their inability encode proteins. Among them, microRNAs, long non-coding RNAs, circular play key regulation pathway PCa. Aberrant expression these dysregulation causes cell proliferation, apoptosis, invasion, migration, angiogenesis Moreover, affect characteristics cells hold promise as diagnostic prognostic biomarkers. Herein, we summarize role during Additionally, present an overview current progress research on correlation between molecules features disease provide novel insights strategies treatment

Language: Английский

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LINC00839 in Human Disorders: Insights into its Regulatory Roles and Clinical Impact, with a Special Focus on Cancer

Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(8), P. 2179 - 2192

Published: Jan. 1, 2024

LINC00839 has captured significant attention within a spectrum of human disorders, including acute lung injury, osteoarthritis, and childhood obesity.Notably, aberrant expression patterns have been observed across diverse cancer tissues cell lines.LINC00839 emerges as an oncogenic factor in tumorigenesis exerts positive influence on tumor-associated behaviors.Its therapeutic potential for various cancers is underscored by its modulatory impact pivotal signaling pathways, such PI3K/AKT, OXPHOS, Wnt/β-catenin.Additionally, LINC00839's role reducing sensitivity to drug radiotherapy interventions presents opportunities targeted intervention.Furthermore, elevated indicates advanced clinicopathological features foretells unfavorable prognoses, validated publications comprehensive analyses tumor types using TCGA datasets.This review elucidates the multiple regulatory mechanisms functional implications diseases, especially malignancies, emphasizing predictive biomarker target disease domains humans.

Language: Английский

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Potential Transcript-Based Biomarkers Predicting Clinical Outcomes of HPV-Positive Head and Neck Squamous Cell Carcinoma Patients

Cells, Journal Year: 2024, Volume and Issue: 13(13), P. 1107 - 1107

Published: June 26, 2024

Human papillomavirus (HPV)-positive Head and Neck Squamous Cell Carcinomas (HNSCC) comprise a particular cancer entity traditionally associated with better clinical outcomes. Around 25% of HNSCC are HPV positive, HPV16 being the most prevalent type. Nevertheless, close to 30% HPV-positive patients have an unfavorable prognosis, revealing that this type tumor exhibits great heterogeneity leading different behaviors. Efforts been made identify RNA molecules prognostic value outcome HNSCC, aim identifying at high risk metastasis, disease recurrence, poor survival, who would require closer follow-up timely intervention. Moreover, molecular identification those good prognosis will allow implementation de-escalating therapeutic strategies, aiming reduce side effects, resulting in quality life. This review compiles series recent studies addressing methodological conceptual approaches aimed searching for potential gene expression-based biomarkers HNSCC.

Language: Английский

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Unraveling the Regulatory Role of HuR/microRNA Axis in Colorectal Cancer Tumorigenesis

Cancers, Journal Year: 2024, Volume and Issue: 16(18), P. 3183 - 3183

Published: Sept. 18, 2024

Colorectal cancer (CRC) remains a significant global health burden with high incidence and mortality. MicroRNAs (miRNAs) are small non-protein coding transcripts, conserved throughout evolution, an important role in CRC tumorigenesis, either upregulated or downregulated various cancers. RNA-binding proteins (RBPs) known as essential regulators of miRNA activity. Human antigen R (HuR) is prominent RBP to drive tumorigenesis pivotal CRC. In this review, we discuss the regulatory HuR/miRNA axis Interestingly, miRNAs can directly target HuR, altering its expression However, HuR also stabilize degrade miRNAs, forming complex feedback loops that activate block CRC-associated signaling pathways. Dysregulation contributes initiation progression. Additionally, HuR-miRNA regulation by other non-coding RNAs, circular RNA (circRNAs), long-non-coding RNAs (lncRNAs) explored here. Understanding interplay could reveal novel biomarkers better diagnostic prognostic accuracy.

Language: Английский

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Evaluation the role of cuproptosis-related genes in the pathogenesis, diagnosis and molecular subtypes identification of atherosclerosis

Heliyon, Journal Year: 2023, Volume and Issue: 9(10), P. e21158 - e21158

Published: Oct. 1, 2023

BackgroundAt present, the pathogenesis of atherosclerosis has not been fully elucidated, and diagnosis treatment face great challenges. Cuproptosis is a novel cell death pattern that might be involved in development atherosclerosis. However, no research reported correlation between cuproptosis atherosclerosis.MethodsThe differential cuproptosis-related genes (CRGs) group control (A-CRGs) were discovered via expression analysis. The analysis, PPI network GO, KEGG GSEA analysis performed to investigate function A-CRGs. differences biological investigated immune infiltration GSVA. LASSO regression, nomogram machine learning models constructed predict risk. molecular subtypes clusters unsupervised cluster Subsequently, we used above methods analyze CRGs (M-CRGs) evaluate identification performance M-CRGs. Finally, verified diagnostic value for role these through validation set vitro experiments.ResultsFive A-CRGs identified they mainly related copper ion metabolism inflammatory response. based on 5 indicated had well value. A total two obtained group. There many functions clusters, such as mitochondrial outer membrane permeabilization primary immunodeficiency. In addition, 3 M-CRGs 2 clusters. Machine showed efficacy. end, results experiment confirmed genes.ConclusionThe may potential promising markers

Language: Английский

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Expression of Mitochondrial Long Non-Coding RNAs, MDL1 and MDL1AS, Are Good Prognostic and/or Diagnostic Biomarkers for Several Cancers, Including Colorectal Cancer

Cancers, Journal Year: 2024, Volume and Issue: 16(5), P. 960 - 960

Published: Feb. 27, 2024

Non-coding RNAs provide new opportunities to identify biomarkers that properly classify cancer patients. Here, we study the biomarker status of mitochondrial long non-coding RNAs, MDL1 and MDL1AS. Expression these genes was studied in public transcriptomic databases. In addition, a cohort 69 locally advanced rectal (LARC) patients with follow-up more than 5 years used determine prognostic value markers. Furthermore, cell lines colorectal (HCT116) breast (MDA-MB-231) carcinoma were employed effects downregulating MDL1AS vitro. (but not MDL1) significantly different tumor cells surrounding tissue tumor-type-specific context. Both accurate for 5-year survival LARC (p = 0.040 p 0.007, respectively) promising areas under curve ROC analyses (0.820 0.930, respectively). downregulation reduced respiration both lines. this produced decrease growth migration on cells, but reverse cells. summary, can be as reliable LARC, expression provides relevant information diagnosis cancers.

Language: Английский

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