Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 11, 2025

This narrative review explores the role of Medical Nutritional Therapy (MNT) in managing Metabolic-Associated Steatotic Liver Disease (MASLD), previously known as nonalcoholic fatty liver disease. It aims to examine effectiveness specific nutritional strategies preventing and treating this obesity-linked Emerging evidence underscores benefits Mediterranean diet, low-carbohydrate diets, intermittent fasting reducing fat, improving insulin sensitivity, mitigating inflammation. Supplementing with vitamin E, omega-3 acids, silymarin can potentially reduce fibrosis promote health. MNT is a key intervention for MASLD management, emphasizing dietary patterns, caloric restriction, nutraceutical supplementation. Integrating these lifestyle modifications, including regular physical activity, offers comprehensive approach metabolic outcomes patients MASLD. Further research needed refine personalize therapeutic interventions.

Language: Английский

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Long-Term Efficacy and Safety of Nutritional and Pharmacological Strategies for Obesity

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 3, 2025

Language: Английский

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Unlocking the potential: very-low-energy ketogenic therapy in obesity-related disorders

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: Jan. 16, 2025

The Very Low-Energy Ketogenic Therapy (VLEKT) is a structured, multi-phase dietary regimen characterized by carbohydrate intake of less than 50 g/day and daily caloric fewer 800 kcal, which induces ketosis facilitates significant weight loss. Evidence suggests that this nutritional therapy can improve glycemic control, lipid profiles, blood pressure, making it promising option for managing type 2 diabetes (T2D) reducing cardiovascular risk. These benefits are achieved through reductions in triglycerides low-density lipoprotein cholesterol (LDL-c), alongside increases high-density (HDL-c). However, the effects VLEKT on metabolism remain controversial. review emphasizes urgent need further research to validate long-term safety efficacy VLEKT. It also highlights critical role personalized plans, supervised healthcare professionals, optimize health outcomes address individual patient needs.

Language: Английский

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Efficacy and Safety of Phase 1 of Very Low Energy Ketogenic Therapy (VLEKT) in Subjects with Obesity and Mild Renal Impairment

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 721 - 721

Published: Feb. 18, 2025

Background: Obesity impairs renal function through direct mechanisms, such as proinflammatory adipocytokine production, and indirect including obesity-related comorbidities. Despite the increasing prevalence of obesity chronic kidney disease (CKD), clinical guidelines for their combined management remain lacking. Very Low Energy Ketogenic Therapy (VLEKT) has demonstrated efficacy in weight loss, but evidence on its safety individuals with mild impairment is limited. This study aimed to assess Phase 1 VLEKT impairment. Methods: cross-sectional included 73 overweight or (mean age 53.7 ± 8.8 years; BMI 35.3 4.2 kg/m2) an estimated glomerular filtration rate (eGFR) at least 60 mL/min/1.73 m2 (evaluated using CKD-EPI equation). Anthropometric (weight, BMI, waist circumference) biochemical parameters (fasting plasma glucose, insulin, cholesterol profile, triglycerides, AST, ALT, urea) were collected baseline after 45 (±2) days VLEKT. Results: At baseline, 54.8% participants had eGFR <90 m2, while 45.2% ≥ 90 no significant differences sex distribution. After VLEKT, both groups showed reductions (p < 0.001), circumference fasting glucose ≤ 0.004), insulin HOMA-IR total LDL LDL/HDL ratio 0.002), triglycerides 0.009), AST 0.034), ALT 0.009). Notably, significantly increased changes observed those m2. Conclusions: could effectively promote loss metabolic improvements without compromising function, even Further research warranted confirm outcomes across all protocol phases.

Language: Английский

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Supplementation with essential amino acids in the early stage of carbohydrate reintroduction after a very-low energy ketogenic therapy (VLEKT) improves body cell mass, muscle strength and inflammation

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 23, 2025

Although little is yet known about the long-term maintenance of very low-energy ketogenic therapy (VLEKT) effects on body composition, muscle strength and inflammation, it plausible to assume that changes may occur, particularly during steps following step, due loss protective ketones concomitant reintroduction carbohydrates. For this reason, present study aimed evaluate supplementation with 8 g per day essential amino acids (EAAs) these parameters. A total 68 women reproductive age grade I obesity who had completed 45 days phase VLEKT (KeNuT protocol) 40 non-ketogenic KeNuT protocol (phase 3, fruit reintroduction) were included in study. Half them (n = 34) followed first step re-educational EAAs (Aminotrofic®: 4 twice daily). Anthropometric parameters, composition via bioelectrical impedance analysis high-sensitivity C-reactive protein (hs-CRP) levels assessed at baseline, pre- post both dietary interventions. At end (before EAA supplementation), two groups did not differ any parameters assessed. phase, supplemented group showed greater magnitudes reduction weight, waist circumference, fat mass (FM) hs-CRP (p < 0.001 for all) increase 0.001), angle cell (BCM) (%) 0.001). These results underline usefulness transitional improve (specifically FM BCM), strength, inflammatory status.

Language: Английский

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Very Low Energy Ketogenic Therapy (VLEKT), Not Only a Price Matter: A Comparison Study on Average Costs of VLEKT with Fresh Foods and Replacement Meals

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 422 - 422

Published: Jan. 24, 2025

Background: Obesity is constantly growing worldwide, representing a serious concern also for healthcare costs. Current anti-obesity pharmacological strategies, although effective, represent significant cost the patient. Similarly, very low energy ketogenic therapy (VLEKT) protocols with replacement meals have high Objectives: The objective of this study was to estimate average costs VLEKT protocol compared those isocaloric diets fresh foods. Methods: VLEKTs and foods were developed considering an ideal young woman man grade II obesity (BMI ≥ 35.0 kg/m2). individual extrapolated from official Italian databases. obtained by consulting catalogs three companies specialized in operating Italy. Results: On monthly basis, food had EUR 253.44 295.67, while 434.91 535.99, man, respectively. Conclusions: Although more expensive than common diet, should be seen not only as dietary method losing weight, but non-pharmacological, medicalized nutritional therapy, useful managing various conditions, even directly related obesity. Like drug requires use specific products that entail higher cost, borne patient, whose benefits emphasized, which go beyond weight loss general health, thus them targeted strategy.

Language: Английский

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Preoperative Nutrition in Bariatric Surgery: A Narrative Review on Enhancing Surgical Success and Patient Outcomes

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 566 - 566

Published: Feb. 2, 2025

Bariatric surgery has become the preferred treatment for individuals with morbid obesity. Nutrition is key in optimizing surgical outcomes by reducing risks and enhancing recovery. Preoperative strategies, such as body fat, decreasing liver size, improving metabolic profiles, have been shown to facilitate safer procedures fewer complications. This narrative review aims provide an analysis of fundamental role preoperative nutritional management bariatric outcomes, emphasizing importance addressing specific challenges enhance safety, recovery, overall health. interventions focus on correcting comorbidities deficiencies, particularly hypovitaminosis micronutrient imbalances, through a multidisciplinary approach involving nutritionists other healthcare professionals. These not only prepare patients physiological demands but also initiate period adaptation new dietary habits, aiming improve long-term compliance mitigate postoperative weight regain dumping syndrome. Adopting changes, very low-calorie or ketogenic diets 6–12 weeks before surgery, enhances adherence restrictions success. Future research should developing comprehensive guidelines care patient globally.

Language: Английский

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Editorial: Understanding obesity to determine the best therapeutic option: from lifestyle interventions to therapies

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 11, 2025

A cornerstone for addressing obesity lies in the promotion of healthy lifestyle habits. Recent findings underscore importance discipline-specific interventions to promote health equity across diverse populations (1). Dietary strategies remain central research. Various types diets, including low-calorie, low-carbohydrate, and high-protein regimens, are tailored individual needs. Studies highlight efficacy Mediterranean diet promoting weight loss improving metabolic health, due its rich nutrient profile anti-inflammatory properties (2). Additionally, ketogenic diets have shown promise by enhancing fat oxidation reducing appetite, making them viable options management (3).Pharmacological therapies progressively recognized as effective alternatives treatment, offering promising results individuals who struggle with lifestylebased interventions. GLP-1 receptor agonists, such semaglutide liraglutide, demonstrated significant improvements (4)(Tamayo-Trujillo et al). Moreover, combination targeting appetite regulation energy expenditure emerging innovative approaches (Vedrenne-Gutierrez Bariatric surgery is another highly intervention managing severe obesity, leading substantial comorbidities. these procedures associated a 59% reduction all-cause mortality among obese adults type 2 diabetes 30% those without that condition (5).Emerging research highlights roles genetic microbial determinants providing insights personalized treatments. Genome-wide association studies (GWAS) identified variants linked susceptibility, FTO gene, which influence (6). Concurrently, reveal gut microbiota composition significantly affects balance showing potential (7).Environmental factors also play crucial role risk (8,9). 2024 scoping review endocrine-disrupting chemicals (EDCs), bisphenols, phthalates, parabens, triclosan, key contributors, emphasizing need preventive (10). These stress considering environmental influences when designing prevention strategies.Collectively, 15 manuscripts this Research Topic offer comprehensive exploration mechanisms spanning changes advanced therapies. multidisciplinary approach effectively combat complex public challenge (Reytor-González al).Lifestyle continue be indispensable. exploring Health at Every Size (HAES) paradigm advocate sustainable body-positive (Suárez al) Meanwhile, dietary strategies, intermittent fasting, effects on warranting further their long-term impacts (Cadena-Ullauri al).Emerging underscores critical body obesity-related risks. For example, oxidative scores provide into interplay between antioxidants, prooxidants, new avenues targeted (Zhu Suarez al. reported assessing muscle mass can help detect adult high developing one It essential healthier eating habits young individuals, highlighted Saintila al., insufficient consumption whole grains, legumes, vegetables, nuts, seeds, along inadequate levels regular physical activity, hydration, sunlight exposure Peruvian university students.Notably, Arteaga-Pazmiño understanding dynapenic coexistence excess low strength, has proven performance impairments aging populations. skeletal anesthesia dosing patients exemplifies integrating analysis clinical practice.(Hu Micronutrient status plays vital management. issue supplementation address common deficiencies vitamin D, calcium, iron (Côté al.). Interestingly, Zambrano point out following bariatric predicting outcomes optimize Furthermore, When nutrition programs post-bariatric patients, it involve specialist. This ensures frequently macro-and micronutrient deficiencies, study from Afsar addressed before initiating supplementation.Also, could mentioned broader societal implications obesity. instance, Diaz links hypovitaminosis D revealing how socio-environmental interact physiological In conclusion, multifaceted nature requires emphasizes interventions, pharmacological advancements combating Emerging predispositions, microbiota, provides treatment. particularly surgery, specialized nutritional strategies. By socio-cultural factors, pave way holistic tackle global crisis.

Language: Английский

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Weight loss, changes in body composition and inflammatory status after a very low-energy ketogenic therapy (VLEKT): does gender matter?

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 19, 2024

Abstract Background Considering differences in body composition and inflammatory status between sexes, as well recent recommendations advocating for personalized dietary approaches, this study aimed to explore how sex influences weight loss, changes composition, subjects with grade I II obesity undergoing a 45-day of the Very Low-Energy Ketogenic Therapy (VLEKT). Methods Participants (21 premenopausal females 21 males), included adhered VLEKT underwent assessments anthropometric parameters (weight, height, mass index—BMI –, waist circumference), via bioelectrical impedance analysis, measured by high sensitivity C-reactive protein (hs-CRP) levels at baseline post-intervention. Results At baseline, males did not differ BMI ( p = 0.100) hs-CRP 0.948). Males demonstrated overall larger benefits than from terms loss (Δ% − 11.63 ± 1.76 vs 8.95 1.65 kg, < 0.001), fat 30.84 12.00 -21.36 4.65 0.002), 41.42 21.35 22.38 17.30 mg/L, 0.003). Of interest, phase angle values are statistically improved compared female 17.11 9.00 7.05 3.30°, 0.001). Conclusion These findings underscore importance considering sex-specific responses treatment strategies, particularly interventions like VLEKTs. Graphical

Language: Английский

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Preventing and Managing Pre- and Postoperative Micronutrient Deficiencies: A Vital Component of Long-Term Success in Bariatric Surgery

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 741 - 741

Published: Feb. 20, 2025

Bariatric surgery (BS) is an effective treatment for severe obesity and its related comorbidities, such as type 2 diabetes hypertension. However, the anatomical physiological changes associated with these procedures significantly increase risk of preoperative postoperative micronutrient deficiencies, which can lead to complications anemia, osteoporosis, neurological disorders. This narrative review examines prevalence clinical implications deficiencies in BS patients, well evidence-based strategies their prevention management. The most common include iron, vitamin B12, folate, calcium, D, fat-soluble vitamins (A, E, K). Procedures a hypoabsorptive component, Roux-en-Y gastric bypass (RYGB) biliopancreatic diversion duodenal switch (BPD/DS), pose higher risks compared restrictive like sleeve gastrectomy (SG). Effective involve correction continuous monitoring, tailored supplementation. long-term adherence supplementation tends decrease over time, influenced by behavioral socioeconomic factors. Hence, preventing managing are crucial success BS. While current guidelines provide valuable recommendations, many based on low-certainty evidence, underscoring need more robust studies. A multidisciplinary approach, combined innovative strategies, telemedicine, enhance achieve sustainable outcomes.

Language: Английский

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