Long-short-term memory machine learning of longitudinal clinical data accurately predicts acute kidney injury onset in COVID-19: a two-center study DOI Creative Commons
Justin Y. Lu,

Joanna Zhu,

Jocelyn Zhu

et al.

International Journal of Infectious Diseases, Journal Year: 2022, Volume and Issue: 122, P. 802 - 810

Published: July 22, 2022

ABSTRACT

Objectives

This study used the long-short-term memory (LSTM) artificial intelligence method to model multiple time points of clinical laboratory data, along with demographics and comorbidities, predict hospital-acquired acute kidney injury (AKI) onset in patients COVID-19.

Methods

Montefiore Health System data consisted 1982 AKI 2857 non-AKI (NAKI) hospitalized COVID-19, Stony Brook Hospital validation 308 721 NAKI Demographic, longitudinal (3 days before onset) tests were analyzed. LSTM was fivefold cross-validation (80%/20% for training/validation).

Results

The top predictors glomerular filtration rate, lactate dehydrogenase, alanine aminotransferase, aspartate C-reactive protein. Longitudinal yielded marked improvement prediction accuracy over individual points. inclusion comorbidities further improves accuracy. best an area under curve, accuracy, sensitivity, specificity be 0.965 ± 0.003, 89.57 1.64%, 0.95 0.03, 0.84 0.05, respectively, dataset, 0.86 0.01, 83.66 2.53%, 0.66 0.10, 0.89 dataset.

Conclusion

accurately predicted approach could help heighten awareness complications identify early interventions prevent long-term renal complications.

Language: Английский

Characterizing non-critically ill COVID-19 survivors with and without in-hospital rehabilitation DOI Creative Commons

Benjamin Musheyev,

Rebeca Janowicz,

Lara Borg

et al.

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: Oct. 26, 2021

Abstract This study investigated pre-COVID-19 admission dependency, discharge assistive equipment, medical follow-up recommendation, and functional status at hospital of non-critically ill COVID-19 survivors, stratified by those with (N = 155) without 162) in-hospital rehabilitation. “Mental Status”, intensive-care-unit (ICU) Mobility, modified Barthel Index scores were assessed discharge. Relative to the non-rehabilitation patients, rehabilitation patients older, had more comorbidities, worse pre-admission discharged equipment supplemental oxygen, spent days in hospital, hospital-acquired acute kidney injury, respiratory failure, referrals ( p < 0.05 for all). Cardiology, vascular medicine, urology, endocrinology amongst top referrals. Functional many survivors abnormal 0.05) associated dependency 0.05). Some negatively correlated age, hypertension, coronary artery disease, chronic psychiatric anemia, neurological disorders In-hospital providing restorative therapies assisting planning challenging circumstances. Knowledge status, recommendations could enable appropriate timely post-discharge care. Follow-up studies are warranted as will likely have significant post-acute sequela.

Language: Английский

Citations

18

Longitudinal medical subspecialty follow-up of critically and non-critically ill hospitalized COVID-19 survivors up to 24 months after discharge DOI Open Access

Benjamin Musheyev,

Montek S. Boparai,

Reona Kimura

et al.

Internal and Emergency Medicine, Journal Year: 2023, Volume and Issue: 18(2), P. 477 - 486

Published: Jan. 31, 2023

Language: Английский

Citations

7

Long-Term outcomes of patients with a pre-existing neurological condition after SARS-CoV-2 infection DOI
Roham Hadidchi,

Yousef Al‐Ani,

Solbie Choi

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Abstract Objectives. This study investigated post COVID-19 outcomes of patients with pre-existing neurological conditions up to 3.5 years post-infection. Methods. retrospective consisted 1,664 (of which 1,320 had been hospitalized for acute COVID-19) and 8,985 non-COVID from the Montefiore Health System in Bronx (Jan-2016 Jul-2023). Primary were all-cause mortality major adverse cardiovascular events (MACE) post-COVID-19. Secondary depression, anxiety, fatigue, headache, sleep disturbances, altered mental status, dyspnea Cox proportional hazards model was used calculate adjusted hazard ratios event (MACE). Cumulative incidence function Fine-Gray sub-distribution analysis performed secondary outcomes. Results. Patients a disease more likely die (adjusted HR = 1.92 [CI:1.60, 2.30], P < 0.005), whereas non-hospitalized rate (aHR 1.08 [CI:0.65, 1.81], 0.76), compared patients. (hospitalized aHR 1.76 [CI:1.53, 2.03], 0.005; not COVID-19: 1.50 [CI:1.09, 2.05], 0.01) experience MACE Notably Blacks 1.49) Hispanics 1.35) higher risk MACE. Both develop cumulative disturbance, (p 0.05). Conclusions. who contracted have worse controls. Identifying at-risk individuals could enable diligent follow-up.

Language: Английский

Citations

2

Long COVID-19 outcomes of patients with pre-existing dementia DOI Creative Commons
Roham Hadidchi,

Rachel Pakan,

Tharun T. Alamuri

et al.

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Although COVID-19 has been linked to worse acute outcomes in patients with some neurodegenerative disorders, its long-term impact on dementia remains unclear.

Language: Английский

Citations

2

Long-short-term memory machine learning of longitudinal clinical data accurately predicts acute kidney injury onset in COVID-19: a two-center study DOI Creative Commons
Justin Y. Lu,

Joanna Zhu,

Jocelyn Zhu

et al.

International Journal of Infectious Diseases, Journal Year: 2022, Volume and Issue: 122, P. 802 - 810

Published: July 22, 2022

ABSTRACT

Objectives

This study used the long-short-term memory (LSTM) artificial intelligence method to model multiple time points of clinical laboratory data, along with demographics and comorbidities, predict hospital-acquired acute kidney injury (AKI) onset in patients COVID-19.

Methods

Montefiore Health System data consisted 1982 AKI 2857 non-AKI (NAKI) hospitalized COVID-19, Stony Brook Hospital validation 308 721 NAKI Demographic, longitudinal (3 days before onset) tests were analyzed. LSTM was fivefold cross-validation (80%/20% for training/validation).

Results

The top predictors glomerular filtration rate, lactate dehydrogenase, alanine aminotransferase, aspartate C-reactive protein. Longitudinal yielded marked improvement prediction accuracy over individual points. inclusion comorbidities further improves accuracy. best an area under curve, accuracy, sensitivity, specificity be 0.965 ± 0.003, 89.57 1.64%, 0.95 0.03, 0.84 0.05, respectively, dataset, 0.86 0.01, 83.66 2.53%, 0.66 0.10, 0.89 dataset.

Conclusion

accurately predicted approach could help heighten awareness complications identify early interventions prevent long-term renal complications.

Language: Английский

Citations

10