Clinical predictors of acute cardiac injury and normalization of troponin after hospital discharge from COVID-19

EBioMedicine, Journal Year: 2022, Volume and Issue: 76, P. 103821 - 103821

Published: Feb. 1, 2022

Although acute cardiac injury (ACI) is a known COVID-19 complication, whether ACI acquired during recovers unknown. This study investigated the incidence of persistent and identified clinical predictors recovery in hospitalized patients with 2.5 months post-discharge.

Language: Английский

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Patients with unmet social needs are at higher risks of developing severe long COVID-19 symptoms and neuropsychiatric sequela

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 2, 2024

Abstract This study investigated long COVID of patients in the Montefiore Health System COVID-19 (CORE) Clinics Bronx with an emphasis on identifying health related social needs (HRSNs). We analyzed a cohort 643 CORE (6/26/2020–2/24/2023) and 52,089 non-CORE patients. Outcomes included symptoms, physical, emotional, cognitive function test scores obtained at least three months post-infection. Socioeconomic variables median incomes, insurance status, HRSNs. The was older age (53.38 ± 14.50 vs. 45.91 23.79 years old, p < 0.001), more female (72.47% 56.86%, had higher prevalence hypertension (45.88% 23.28%, diabetes (22.86% 13.83%, COPD (7.15% 2.28%, asthma (25.51% 12.66%, lower incomes (53.81% 43.67%, 1 st quintile, unmet (29.81% 18.49%, 0.001) compared to survivors. reported wide range severe long-COVID symptoms. HRSNs experienced worse ESAS-r (tiredness, wellbeing, shortness breath, pain), PHQ-9 (12.5 (6, 17.75) 7 (2, 12), GAD-7 (8.5 (3, 15) 4 (0, 9), without. Patients outcomes those

Language: Английский

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Long-term outcomes of hospitalized patients with SARS-CoV-2/COVID-19 with and without neurological involvement: 3-year follow-up assessment

PLoS Medicine, Journal Year: 2024, Volume and Issue: 21(4), P. e1004263 - e1004263

Published: April 4, 2024

Background Acute neurological manifestation is a common complication of acute Coronavirus Disease 2019 (COVID-19) disease. This retrospective cohort study investigated the 3-year outcomes patients with and without significant manifestations during initial COVID-19 hospitalization. Methods findings Patients hospitalized for Severe Respiratory Syndrome 2 (SARS-CoV-2) infection between 03/01/2020 4/16/2020 in Montefiore Health System Bronx, an epicenter early pandemic, were included. Follow-up data was captured up to 01/23/2023 (3 years post-COVID-19). consisted 414 1,199 propensity-matched (for age severity score) manifestations. Neurological involvement phase included stroke, new or recrudescent seizures, anatomic brain lesions, presence altered mentation evidence impaired cognition arousal, neuro-COVID-19 complex (headache, anosmia, ageusia, chemesthesis, vertigo, presyncope, paresthesias, cranial nerve abnormalities, ataxia, dysautonomia, skeletal muscle injury normal orientation arousal signs). There no group differences female sex composition (44.93% versus 48.21%, p = 0.249), ICU IMV status, white, not Hispanic (6.52% 7.84%, 0.380), (33.57% 38.20%, 0.093), except black non-Hispanic (42.51% 36.03%, 0.019). Primary mortality, heart attack, major adverse cardiovascular events (MACE), reinfection, hospital readmission post-discharge. Secondary neuroimaging (hemorrhage, active prior mass effect, microhemorrhages, white matter changes, microvascular disease (MVD), volume loss). More discharged rehabilitation (10.39% 3.34%, < 0.001) skilled nursing facilities (35.75% 25.35%, fewer home (50.24% 66.64%, than matched controls. Incidence any reason (65.70% 60.72%, 0.036), stroke (6.28% 2.34%, 0.001), MACE (20.53% 16.51%, 0.032) higher Per Kaplan–Meier univariate survival curve analysis, such more likely die post-discharge compared controls (hazard ratio: 2.346, (95% confidence interval (CI) [1.586, 3.470]; 0.001)). Across both cohorts, causes death (13.79% neurological, 15.38% control), sepsis (8.63%, 17.58%), influenza pneumonia (13.79%, 9.89%), (10.34%, 7.69%), respiratory distress syndrome (ARDS) 6.59%). Factors associated mortality after leaving involved (odds ratio (OR): 1.802 CI [1.237, 2.608]; 0.002)), discharge disposition (OR: 1.508 [1.276, 1.775]; 0.001)), congestive failure 2.281 [1.429, 3.593]; score 1.177 [1.062, 1.304]; older 1.027 [1.010, 1.044]; 0.002)). radiological findings, that showed significantly age-adjusted loss ( 0.045) The study’s patient limited infected first wave when hospitals overburdened, vaccines yet available, treatments limited. Patient profiles might differ interrogating subsequent waves. Conclusions had worse long-term These raise awareness need closer monitoring timely interventions manifestations, as their course involving enhanced morbidity mortality.

Language: Английский

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Outcomes of Hospitalized Patients With COVID-19 With Acute Kidney Injury and Acute Cardiac Injury

Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 8

Published: Feb. 15, 2022

This study investigated the incidence, disease course, risk factors, and mortality in COVID-19 patients who developed both acute kidney injury (AKI) cardiac (ACI), compared to those with AKI only, ACI no (NI).This retrospective consisted of hospitalized at Montefiore Health System Bronx, New York between March 11, 2020 January 29, 2021. Demographics, comorbidities, vitals, laboratory tests were collected during hospitalization. Predictive models used predict AKI, ACI, AKI-ACI onset. Longitudinal analyzed time-lock discharge alive or death.Of 5,896 patients, 44, 19, 9, 28% had NI, AKI-ACI, respectively. Most presented very early (within a day two) hospitalization contrast (p < 0.05). Patients combined significantly older, more often men higher levels cardiac, kidney, liver, inflammatory, immunological markers NI groups. The adjusted hospital-mortality odds ratios 17.1 [95% CI = 13.6-21.7, p 0.001], 7.2 5.4-9.6, 4.7 3.7-6.1, 0.001] for respectively, relative NI. A predictive model onset using top predictors yielded 97% accuracy. data predicted up 5 days prior outcome, an area-under-the-curve, ranging from 0.68 0.89.COVID-19 markedly worse outcomes only Common variables accurately AKI-ACI. ability identify could lead earlier intervention improvement clinical outcomes.

Language: Английский

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COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses

Epidemiology and Psychiatric Sciences, Journal Year: 2023, Volume and Issue: 32

Published: Jan. 1, 2023

Abstract Aims It has been suggested that people with mental disorders have an elevated risk to acquire severe acute respiratory syndrome coronavirus 2 and be disproportionally affected by disease 19 (COVID-19) once infected. We aimed analyse the COVID-19 infection rate, course outcome, including mortality long COVID, in anxiety, depressive, neurodevelopmental, schizophrenia spectrum substance use relative control subjects without these disorders. Methods This study constitutes a preregistered systematic review random-effects frequentist Bayesian meta-analyses. Major databases were searched up until 27 June 2023. Results Eighty-one original articles included reporting 304 cross-sectional prospective effect size estimates (median n per effect-size = 114837) regarding associations of interest. Infection was not significantly increased for any disorder we investigated samples The COVID-19, however, is relatively severe, COVID COVID-19-related hospitalization are more likely all patient investigated. odds dying from high most types disorders, except those anxiety neurodevelopmental non-patient (pooled ORs range, 1.26–2.57). analyses confirmed findings approach complemented them strength evidence. Conclusions Once infected, pre-existing at mortality, despite increased.

Language: Английский

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COVID-19 Patients in the COVID-19 Recovery and Engagement (CORE) Clinics in the Bronx

Diagnostics, Journal Year: 2022, Volume and Issue: 13(1), P. 119 - 119

Published: Dec. 30, 2022

Background: Early in the pandemic, we established COVID-19 Recovery and Engagement (CORE) Clinics Bronx implemented a detailed evaluation protocol to assess physical, emotional, cognitive function, pulmonary function tests, imaging for survivors. Here, report our findings up five months post-acute COVID-19. Methods: Main outcomes measures included battery of symptom, assessments 5 Findings: Dyspnea, fatigue, decreased exercise tolerance, brain fog, shortness breath were most common symptoms but there generally no significant differences between hospitalized non-hospitalized cohorts (p > 0.05). Many patients had abnormal scores, functioned independently; Six-minute walk lung ultrasound, diaphragm excursion only cohort. Pulmonary tests showed moderately restrictive cohort obstructive function. Newly detected major neurological events, microvascular disease, atrophy, white-matter changes rare, opacity fibrosis-like after acute Interpretation: survivors experienced across health domains. abnormalities common. This study provides insights into sequelae following SARS-CoV-2 infection systems which may be used support at-risk develop effective screening methods interventions.

Language: Английский

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Longitudinal medical subspecialty follow-up of critically and non-critically ill hospitalized COVID-19 survivors up to 24 months after discharge

Internal and Emergency Medicine, Journal Year: 2023, Volume and Issue: 18(2), P. 477 - 486

Published: Jan. 31, 2023

Language: Английский

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Factors associated with infection and hospitalization due to COVID-19 in Nursing professionals: a cross-sectional study

Revista Latino-Americana de Enfermagem, Journal Year: 2022, Volume and Issue: 30

Published: Jan. 1, 2022

Abstract Objective: to identify factors associated with infection and hospitalization due COVID-19 in nursing professionals. Method: a cross-sectional study carried out 415 professionals hospital specialized cardiology. The sociodemographic variables, comorbidities, working conditions issues related illness were evaluated. Chi-Square, Fisher’s, Wilcoxon, Mann-Whitney Brunner Munzel tests used data analysis, as well Odds Ratio for hospitalization, addition binary logistic regression. Results: the rate of affected by was 44.3% number people living same household infected (OR 36.18; p<0.001) use public transportation 2.70; p=0.044). Having severe symptoms 29.75), belonging risk group 3.00), having tachypnea 6.48), shortness breath 5.83), tiredness 4.64), fever 4.41) and/or myalgia 3.00) increased chances COVID-19. Conclusion: other disease using new coronavirus. contaminated presence disease, severity type presented.

Language: Английский

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Long-term outcomes of hospitalized SARS-CoV-2/COVID-19 patients with and without neurological involvement: 3-year follow-up assessment

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 29, 2023

ABSTRACT Background and Objectives Acute neurological manifestations are a common complication of acute COVID-19 disease. This study investigated the 3-year outcomes patients with without significant during initial hospitalization. Methods Patients infected by SARS-CoV-2 between March 1 April 16, 2020 hospitalized in Montefiore Health System Bronx, an epicenter early pandemic, were included. Follow-up data was captured up to January 23, 2023 (3 years post COVID-19). cohort consisted 414 1199 propensity-matched COVID- 19 manifestations. Primary mortality, stroke, heart attack, major adverse cardiovascular events (MACE), reinfection, hospital readmission post-discharge. Secondary clinical neuroimaging findings (hemorrhage, active prior mass effect, microhemorrhage, white-matter changes, microvascular disease, volume loss). Predictive models used identify risk factors mortality Results More discharged rehabilitation (10.54% vs 3.68%, p<0.0001), skilled nursing facilities (30.67% 20.78%, p=0.0002) fewer home (55.27% 70.21%, p<0.0001) compared matched controls. Incidence for any medical reason (65.70% 60.72%, p=0.036), stroke (6.28% 2.34%, MACE (20.53% 16.51%, p=0.032) higher Neurological more likely die post-discharge (58 (14.01%) 94 (7.84%), p=0.0001) controls (HR=2.346, 95% CI=(1.586, 3.470), p<0.0001). The causes death disease (14.47%), sepsis (13.82%), influenza pneumonia (11.18%), (8.55%) respiratory distress syndrome (7.89%). Factors associated after leaving belonging (OR=1.802 (1.237, 2.608), p=0.002), discharge disposition (OR=1.508, CI=(1.276, 1.775), congestive failure (OR=2.281 (1.429, 3.593), p=0.0004), severity score (OR=1.177 (1.062, 1.304), older age (OR=1.027 (1.010, 1.044), p=0.002). There no group differences gross radiological findings, except showed significantly age-adjusted brain loss (p<0.05) Discussion have worse long-term These raise awareness need closer monitoring timely interventions

Language: Английский

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Fatores associados à contaminação e internação hospitalar por COVID-19 em profissionais de enfermagem: estudo transversal

Revista Latino-Americana de Enfermagem, Journal Year: 2022, Volume and Issue: 30

Published: Jan. 1, 2022

to identify factors associated with infection and hospitalization due COVID-19 in nursing professionals.

Language: Английский

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