One-year pulmonary impairment after severe COVID-19: a prospective, multicenter follow-up study

Respiratory Research, Journal Year: 2022, Volume and Issue: 23(1)

Published: March 21, 2022

Long-term pulmonary sequelae following hospitalization for SARS-CoV-2 pneumonia is largely unclear. The aim of this study was to identify and characterise caused by at 12-month from discharge.

Language: Английский

---

The Impact of Long COVID-19 on Muscle Health

Clinics in Geriatric Medicine, Journal Year: 2022, Volume and Issue: 38(3), P. 545 - 557

Published: March 21, 2022

COVID-19 negatively impacts several organs and systems weeks or months after initial diagnosis. Skeletal muscle can be affected, leading to fatigue, lower mobility, weakness, poor physical performance. Older adults are at increased risk of developing musculoskeletal symptoms during long COVID. Systemic inflammation, inactivity, nutritional status some the mechanisms dysfunction in individuals with Current evidence suggests that COVID body composition, function, quality life. Muscle mass function assessments contribute toward identification, diagnosis, management health resulting from

Language: Английский

---

The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications

Biochemical Journal, Journal Year: 2022, Volume and Issue: 479(16), P. 1653 - 1708

Published: Aug. 31, 2022

Ischaemia-reperfusion (I-R) injury, initiated via bursts of reactive oxygen species produced during the reoxygenation phase following hypoxia, is well known in a variety acute circumstances. We argue here that I-R injury also underpins elements pathology chronic, inflammatory diseases, including rheumatoid arthritis, ME/CFS and, our chief focus and most proximally, Long COVID. Ischaemia may be fibrin amyloid microclot blockage capillaries, for instance as exercise started; reperfusion necessary corollary when it finishes. rehearse mechanistic evidence these occurrences here, terms their manifestation oxidative stress, hyperinflammation, mast cell activation, production marker metabolites related activities. Such microclot-based phenomena can explain both breathlessness/fatigue post-exertional malaise observed conditions, many other observables. The recognition processes implies, mechanistically, therapeutic benefit potentially to had from antioxidants, anti-inflammatories, iron chelators, suitable, safe fibrinolytics, and/or anti-clotting agents. review considerable existing consistent with this, biochemical mechanisms involved.

Language: Английский

---

Headache, anosmia, ageusia and other neurological symptoms in COVID-19: a cross-sectional study

The Journal of Headache and Pain, Journal Year: 2022, Volume and Issue: 23(1)

Published: Jan. 3, 2022

Abstract Background Neurological symptoms are frequent among patients with COVID-19. Little is known regarding the repercussions of neurological for and how these related to one another. Objectives To determine whether there an association between in COVID-19, characterize headache. Method This was a cross-sectional study. All hospital inpatients health workers at Hospital Universitario Oswaldo Cruz PCR-confirmed COVID-19 infection March June 2020 were considered study interviewed by telephone least 2-months after acute phase disease. These identified epidemiological surveillance department. A semi-structured questionnaire used containing sociodemographic clinical data ID-Migraine. Results total 288 interviewed; 53.1% male; median age 49.9 (41.5–60.5) years; 91.7% presented some symptom; 22.2% reported symptom as that troubled them most during were: ageusia (69.8%), headache (69.1%), anosmia (67%), myalgia (44.4%), drowsiness (37.2%), agitation (20.8%); mental confusion (14.9%), syncope (4.9%) epileptic seizures (2.8%). Females, those who fever, sore throat, anosmia/ageusia also significantly more (logistic regression). The phenotype non-migraine phenotype, severe intensity differed from previous headaches. persisted than 30 days 18% 90 10% patients. Thirteen percent 11% continued complaints Aged over 50 years, associated Conclusion Headache other such anosmia, ageusia, myalgia, may persist beyond

Language: Английский

---

Olfactory Dysfunction, Headache, and Mental Clouding in Adults with Long-COVID-19: What Is the Link between Cognition and Olfaction? A Cross-Sectional Study

Brain Sciences, Journal Year: 2022, Volume and Issue: 12(2), P. 154 - 154

Published: Jan. 24, 2022

Smell alteration and cognitive impairment are common features of the Long-COVID Syndrome. Mental clouding, often described as brain fog, might affect smell by altering recollection odors or through a share mechanism neuroinflammation. We investigated mental headache, function in adult patients with persistent COVID-19 olfactory dysfunction. This multi-center cross-sectional study enrolled 152 adults self-reported dysfunction from 3 tertiary centers specialized disorders. Inclusion criteria were alterations after persisting over 6 months infection, age >18 < 65. Exclusion included alterations, memory problems prior to infection. The evaluated olfactometry, nasal endoscopy, headache scale, assessment, Mini State Examination (MMSE), measures. was stratified classified based on deficit severity presence distortion (parosmia, cacosmia). Data disorder, MMSE, analyzed assess correlations. Among studied, 50 (32.8%) presented anosmia, 25 (16.4%) hyposmia, 10 (6.6%) parosmia/cacosmia, 58 (38.2%) combination hyposmia parosmia; seven (4.6%) suffered exclusively, two (1.4%) had clouding their primary symptom. Headache reported 76 (50%) patients, 71 (46.7%). reporting both, significantly increased risk suffering anosmia and/or when compared counterparts without these neurological symptoms. No reduced MMSE scores. In our cohort post-COVID-19, months, associated more severe loss, consistent neuroinflammatory mechanisms mediating variety

Language: Английский

---

The Musculoskeletal Involvement After Mild to Moderate COVID-19 Infection

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: March 18, 2022

COVID-19, a disease caused by the novel coronavirus SARS-CoV-2, has been drastically affecting daily lives of millions people. COVID-19 is described as multiorgan that affects not only respiratory tract infected individuals, but it considerable effects on musculoskeletal system, causing excessive fatigue, myalgia, arthralgia, muscle weakness and skeletal damage. These symptoms can persist for months, decreasing quality life numerous individuals. Curiously, most studies in scientific literature focus patients who were hospitalized due to SARS-CoV-2 infection little known about mechanism action muscles, especially individuals had mild moderate forms (non-hospitalized patients). In this review, we current knowledge system highlighting lack researches investigating cases pointing out why essential care these patients. Also, will comment need more experimental data assess manifestations COVID-19-positive

Language: Английский

---

Post-acute health care burden after SARS-CoV-2 infection: a retrospective cohort study

Canadian Medical Association Journal, Journal Year: 2022, Volume and Issue: 194(40), P. E1368 - E1376

Published: Oct. 16, 2022

The post-acute burden of health care use after SARS-CoV-2 infection is unknown. We sought to quantify the among community-dwelling adults in Ontario by comparing those with positive and negative polymerase chain reaction (PCR) test results for infection.We conducted a retrospective cohort study involving who had PCR between Jan. 1, 2020, Mar. 31, 2021. Follow-up began 56 days testing. matched people 1:1 on comprehensive propensity score. compared per-person-year rates encounters at mean 99th percentiles, counts using binomial models, stratified sex.Among 531 702 people, age was 44 (standard deviation [SD] 17) years 51% were female. Females tested 1.98 (95% CI 1.63 2.29) more overall than result, 0.31 0.05 0.56) home 0.81 0.69 0.93) long-term days. At percentile per-person-year, females 6.48 hospital admission 28.37 encounters. Males 0.66 0.34 0.99) negative, 0.14 0.06 0.21) outpatient 0.48 0.36 0.60) days, 0.43 -0.67 -0.21) fewer percentile, they 8.69 (-27.31) (-0.87) encounters.We found significantly higher an analysis that test-positive test-negative people. Stakeholders can these findings prepare demand associated post-COVID-19 condition (long COVID).

Language: Английский

---

COVID-19 Induced Postural Orthostatic Tachycardia Syndrome (POTS): A Review

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: March 31, 2023

POTS (Postural Orthostatic Tachycardia Syndrome) is a multisystem disorder characterized by the abnormal autonomic response to an upright posture, causing orthostatic intolerance and excessive tachycardia without hypotension. Recent reports suggest that significant percentage of COVID-19 survivors develop within 6 8 months infection. Prominent symptoms include fatigue, intolerance, tachycardia, cognitive impairment. The exact mechanisms post-COVID-19 are unclear. Still, different hypotheses have been given, including autoantibody production against nerve fibers, direct toxic effects SARS-CoV-2, or sympathetic nervous system stimulation secondary Physicians should high suspicion in survival when presented with dysfunction conduct diagnostic tests like Tilt table others confirm it. management COVID-19-related requires comprehensive approach. Most patients respond initial non-pharmacological options, but become more severe they do not approach, pharmacological options considered. We limited understanding knowledge POTS, further research warranted improve our formulate better plan.

Language: Английский

---

Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+β7 integrin+ T cells and anti-SARS-CoV-2 IgA response

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 30, 2023

Abstract Several millions of individuals are estimated to develop post-acute sequelae SARS-CoV-2 condition (PASC) that persists for months after infection. Here we evaluate the immune response in convalescent with PASC compared asymptomatic and uninfected participants, six following their COVID-19 diagnosis. Both cases characterised by higher CD8 + T cell percentages, however, proportion blood cells expressing mucosal homing receptor β7 is low patients. show increased expression PD-1, perforin granzyme B PASC, plasma levels type I III (mucosal) interferons elevated. The humoral characterized IgA against N S viral proteins, particularly those who had severe acute disease. Our results also consistently elevated IL-6, IL-8/CXCL8 IP-10/CXCL10 during disease increase risk PASC. In summary, our study indicates defined persisting immunological dysfunction as late infection, including alterations parameters, redistribution β7Integrin IgA, indicative potential persistence involvement etiopathology

Language: Английский

---

Psychiatric symptoms in Long-COVID patients: a systematic review

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: June 21, 2023

People who have been infected by COVID-19 showing persistent symptoms after 4 weeks from recovery are thought to suffer Long-COVID syndrome (LC). There is uncertainty on the clinical manifestations of LC. We undertook a systematic review summarize available evidence about main psychiatric LC.PubMed (Medline), Scopus, CINHAL, PsycINFO, and EMBASE were searched until May 2022. Studies reporting estimation emerging and/or diagnoses among adult people with LC included. Pooled prevalence for each condition was calculated in absence control groups compare with.Thirty-three reports included final selection, corresponding 282,711 participants After infection recovery, reported following symptoms: depression, anxiety, post-traumatic (PTS), cognitive sleeping disturbances (i.e., insomnia or hypersomnia). The most common manifestation resulted be sleep disturbances, followed PTS, impairment attention memory deficits). However, some estimates affected important outlier effect played one study. If study weight not considered, anxiety.LC may non-specific manifestations. More research needed better define differentiate it other post-infectious post-hospitalization syndromes.PROSPERO (CRD42022299408).

Language: Английский

---