Long COVID headache

The Journal of Headache and Pain, Journal Year: 2022, Volume and Issue: 23(1)

Published: Aug. 1, 2022

Abstract Headache is among the most frequent symptoms persisting or newly developing after coronavirus disease 2019 (COVID-19) as part of so-called long COVID syndrome. The knowledge on headache still limited, however growing evidence defining features this novel condition, in particular regarding clinical characteristics, some pathophysiological mechanisms and first treatment recommendations. Long can present form worsening a preexisting primary headache, or, more specifically, new (intermittent daily) starting during acute infection delay. It often presents together with other symptoms, frequently hyposmia. manifest migrainous frequently, tension-type-like phenotype. Persistent activation immune system trigeminovascular are thought to play role. As there virtually no studies, currently largely guided by existing guidelines for headaches corresponding report, collaborative work international group Junior Editorial Board Journal Pain aims summarize recent about suggests approaches diagnosis disorder. Graphical

Language: Английский

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Effect of Ultra-Micronized Palmitoylethanolamide and Luteolin on Olfaction and Memory in Patients with Long COVID: Results of a Longitudinal Study

Cells, Journal Year: 2022, Volume and Issue: 11(16), P. 2552 - 2552

Published: Aug. 17, 2022

In this study, we investigated whether treatment with palmitoylethanolamide and luteolin (PEA-LUT) leads to improvement in the quantitative or qualitative measures of olfactory dysfunction relief from mental clouding patients affected by long COVID. Patients COVID were allocated different groups based on presence (“previously treated”) absence (“naïve”) prior exposure training. then randomized receive PEA-LUT alone combination Olfactory function memory assessed at monthly intervals using self-report thresholds. A total 69 (43 women, 26 men) an age average 40.6 + 10.5 recruited. therapy was associated a significant validated odor identification scores baseline versus each subsequent month; assessment 3 months showed 10.7 2.6, CI 95%: 6–14 (p < 0.0001). The overall prevalence parosmia 79.7% (55 patients), 0.0001), namely 31 Naïve 1 group (72%), 15 2 (93.7%), 9 remaining (90%). Overall, detected 37.7% (26 subjects) cases, reduction severity three = 0.02), (34.8%), 7 (43.7%), 4 (40%). Conclusions. chronic loss, regimen including oral training ameliorated memory. Further investigations are necessary discern biomarkers, mechanisms, long-term outcomes.

Language: Английский

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Cognition and Long COVID: A PRISMA Systematic Review of Longitudinal Studies

Revista de Neurología, Journal Year: 2025, Volume and Issue: 79(12)

Published: Jan. 24, 2025

Introduction: Long COVID is defined by National Institute for Health and Care Excellence (NICE) as the set of signs symptoms that develop during or after a SARS-CoV-2 infection continue more than twelve weeks without any alternative diagnosis. One most frequent persistent reported patients verified in neuroimaging studies cognitive dysfunction, due to generalized hypoconnectivity diffuse axonal lesion white matter. Therefore, objectives present review are determine how long functions remain affected explore which beyond three months follow-up up 65 years age previous neuropsychological psychiatric complications. Methods: A systematic was performed using PRISMA criteria 11 articles were included through comprehensive search five different databases: PubMed, Medline, Scopus, WOS ProQuest. The risk bias assessed Newcastle-Ottawa scale. Results: Cognitive problems persist over time improve slowly, although seem agree areas improved significantly one year. remained impaired longest processing speed attention. Conclusions: These alterations cause reduction quality life work capacity manifest need intervention.

Language: Английский

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A Comprehensive Review of COVID-19-Related Olfactory Deficiency: Unraveling Associations with Neurocognitive Disorders and Magnetic Resonance Imaging Findings

Diagnostics, Journal Year: 2024, Volume and Issue: 14(4), P. 359 - 359

Published: Feb. 7, 2024

Olfactory dysfunction (OD) is one of the most common symptoms in COVID-19 patients and can impact patients’ lives significantly. The aim this review was to investigate multifaceted on olfactory system provide an overview magnetic resonance (MRI) findings neurocognitive disorders with COVID-19-related OD. Extensive searches were conducted across PubMed, Scopus, Google Scholar until 5 December 2023. included articles 12 observational studies 1 case report that assess structural changes structures, highlighted through MRI, 10 correlating loss smell or mood patients. MRI consistently indicate volumetric abnormalities, altered signal intensity bulbs (OBs), anomalies cortex among persistent correlation between OD deficits reveals associations cognitive impairment, memory deficits, depressive symptoms. Treatment approaches, including training pharmacological interventions, are discussed, emphasizing need for sustained therapeutic interventions. This points out several limitations current literature while exploring intricate effects its connection disorders. lack objective measurements some potential validity issues self-reports emphasize cautious interpretation. Our research highlights critical extensive larger samples, proper controls, deepen our understanding COVID-19’s long-term neurological dysfunctions.

Language: Английский

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Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from migraine: a case–control study

The Journal of Headache and Pain, Journal Year: 2022, Volume and Issue: 23(1)

Published: Aug. 12, 2022

The burden of post-coronavirus disease (COVID)-19 symptoms has been increasing and is great concern in patients with pre-existing chronic medical conditions.This study aimed to delineate the post-COVID-19 neuropsychiatric among migraine compared non-migraine control group.

Language: Английский

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Psychological and Cognitive Effects of Long COVID: A Narrative Review Focusing on the Assessment and Rehabilitative Approach

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(21), P. 6554 - 6554

Published: Nov. 4, 2022

Long COVID is a clinical syndrome characterized by profound fatigue, neurocognitive difficulties, muscle pain, weakness, and depression, lasting beyond the 3–12 weeks following infection with SARS-CoV-2. Among symptoms, psychiatric sequelae, including attention memory alterations, as well anxiety depression have become major targets of current healthcare providers given significant public health impact. In this context, assessment tools play crucial role in early screening cognitive alterations due to COVID. others, general tools, such Montreal Cognitive assessment, more specific ones, State Trait Inventory Fatigue Digit Span, may be help investigating main alterations. Moreover, appropriate neurorehabilitative programs using methods techniques (conventional and/or advanced) through multidisciplinary team are required treat COVID-19-related behavioral abnormalities. narrative review, we sought describe symptoms provide some advice for treatment

Language: Английский

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A murine model of post-acute neurological sequelae following SARS-CoV-2 variant infection

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 3, 2024

Viral variant is one known risk factor associated with post-acute sequelae of COVID-19 (PASC), yet the pathogenesis largely unknown. Here, we studied SARS-CoV-2 Delta variant-induced PASC in K18-hACE2 mice. The virus replicated productively, induced robust inflammatory responses lung and brain tissues, caused weight loss mortality during acute infection. Longitudinal behavior studies surviving mice up to 4 months infection revealed persistent abnormalities neuropsychiatric state motor behaviors, while reflex sensory functions recovered over time. In brain, no detectable viral RNA minimal residential immune cell activation was observed Transcriptome analysis pathways, including humoral responses, complement, phagocytosis, gene expression levels ataxia telangiectasia, impaired cognitive function memory recall, neuronal dysfunction degeneration. Furthermore, maintained potent systemic T helper 1 prone cellular strong sera neutralizing antibodies against Omicron variants Overall, our findings suggest that recapitulates clinical symptoms reported long-COVID patients provides new insights into role factors pathogenesis.

Language: Английский

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Animal models of Long Covid: A hit-and-run disease

Science Translational Medicine, Journal Year: 2024, Volume and Issue: 16(773)

Published: Nov. 13, 2024

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) pandemic has caused more than 7 million deaths globally. Despite the presence of infection- and vaccine-induced immunity, SARS-CoV-2 infections remain a major global health concern because emergence variants that can cause disease 2019 (COVID-19) or enhance Long Covid phenotypes. About 5 to 10% SARS-CoV-2-infected individuals develop Covid, which, similar COVID 19, often affects lung. However, also affect other peripheral organs, especially brain. causal relationships between phenotypes, long-term symptoms, involvement multiple organ systems elusive, animal model mimicking both post-acute phases are imperative. Here, we review current state models, including possible future applications.

Language: Английский

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Treatment of COVID-19 olfactory dysfunction with olfactory training, palmitoylethanolamide with luteolin, or combined therapy: a blinded controlled multicenter randomized trial

European Archives of Oto-Rhino-Laryngology, Journal Year: 2023, Volume and Issue: 280(11), P. 4949 - 4961

Published: June 28, 2023

Abstract Purpose Few evidence-based therapies are available for chronic olfactory dysfunction after COVID-19. This study investigated the relative efficacy of training alone, co-ultramicronized palmitoylethanolamide with luteolin (um-PEA–LUT, an anti-neuroinflammatory supplement) or combined therapy treating from Methods double-blinded controlled, placebo-controlled multicenter randomized clinical trial was conducted in 202 patients persistent COVID-19 > 6 month duration. After a screening nasal endoscopy, were to: (1) and placebo; (2) once daily um-PEA–LUT alone; (3) twice (4) combination training. Olfactory testing (Sniffin’ Sticks odor identification test) performed at baseline 1, 2, 3 months. The primary outcome recovery over three points on testing, outcomes compared T 0 , 1 2 across groups. Statistical analyses included one-way ANOVA numeric data chi-square nominal data. Results All completed study, there no adverse events. At 90 days, scores improved by 89.2% receiving vs. 36.8% placebo, 40% 41.6% alone ( p < 0.00001). Patients treatment demonstrated subclinical improvement (< point improvement) more often than placebo 0.0001.) Conclusions plus resulted greater either long-term function due to Trial registration 20112020PGFN clinicaltrials.gov. Level evidence 1b (Individual Randomized Clinical Trial).

Language: Английский

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Hippocampal alterations after SARS-CoV-2 infection: A systematic review

Behavioural Brain Research, Journal Year: 2023, Volume and Issue: 455, P. 114662 - 114662

Published: Sept. 12, 2023

SARS-CoV-2 infection produces a wide range of symptoms. Some the structural changes caused by virus in nervous system are found medial temporal lobe, and several neuropsychological sequelae COVID-19 related to function hippocampus. The main objective systematic review is update further analyze existing evidence hippocampal cortices' functional alterations due infection. Both clinical preclinical studies that used different methodologies explore effects this disease at stages grades severity were considered, besides exploring cognitive emotional symptomatology. A total 24 identified searching SCOPUS, Web Of Science (WOS), PubMed, PsycInfo databases up October 3rd, 2022. Thirteen performed human samples, 9 included animal models, 3 post-mortem, 1 both post-mortem samples. Alterations hippocampus detected acute stage after months Clinical revealed connectivity metabolism. Memory correlated with altered metabolic profiles or grey matter volumes. Hippocampal postmortem observed neurogenesis, dendrites, immune response, high apoptosis neuroinflammation. Preclinical reported viral load Olfactory dysfunction was associated brain functionality. Several complaints, alterations, depressive anxious

Language: Английский

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