Drug Delivery and Translational Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 17, 2025
Abstract
Given
the
recurrent
waves
of
COVID-19
and
emergence
new
viral
infections,
optimizing
potential
remdesivir
as
an
antiviral
agent
is
critical.
While
several
reviews
have
explored
efficacy
remdesivir,
few
comprehensively
addressed
its
challenges,
such
necessity
for
intravenous
infusion,
suboptimal
lung
accumulation,
safety
concerns
related
to
formulation.
This
review
critically
examines
these
challenges
while
proposing
innovative
solutions
effective
combinations
with
other
agents
repurposed
drugs.
By
highlighting
role
complex
generics,
we
aim
enhance
therapeutic
in
ways
not
previously
discussed
existing
literature.
Furthermore,
address
development
novel
drug
delivery
systems
which
specifically
improve
remdesivir's
pharmacological
profile.
analyzing
recent
findings,
assess
both
successes
limitations
current
approaches,
providing
insights
into
ongoing
strategies
further
optimization.
uniquely
focuses
on
targeted
formulations,
thereby
maximizing
benefits
broadening
application
combating
emerging
threats.
In
doing
so,
fill
a
critical
gap
literature,
offering
comprehensive
overview
that
informs
future
research
clinical
strategies.
Graphical
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
201, P. 107086 - 107086
Published: Jan. 29, 2024
The
progress
in
human
disease
treatment
can
be
greatly
advanced
through
the
implementation
of
nanomedicine.
This
approach
involves
targeted
and
cell-specific
therapy,
controlled
drug
release,
personalized
dosage
forms,
wearable
delivery,
companion
diagnostics.
By
integrating
cutting-edge
technologies
with
delivery
systems,
greater
precision
achieved
at
tissue
cellular
levels
use
stimuli-responsive
nanoparticles,
development
electrochemical
sensor
systems.
targeting
–
by
virtue
nanotechnology
allows
for
therapy
to
directed
specifically
affected
tissues
while
reducing
side
effects
on
healthy
tissues.
As
such,
nanomedicine
has
potential
transform
conditions
such
as
cancer,
genetic
diseases,
chronic
illnesses
facilitating
precise
delivery.
Additionally,
forms
devices
offer
ability
tailor
unique
needs
each
patient,
thereby
increasing
therapeutic
effectiveness
compliance.
Companion
diagnostics
further
enable
efficient
monitoring
response,
enabling
customized
adjustments
plan.
question
whether
all
approaches
outlined
here
are
viable
alternatives
current
treatments
is
also
discussed.
In
general,
application
field
biomedicine
may
provide
a
strong
alternative
existing
several
reasons.
this
review,
we
aim
present
evidence
that,
although
early
stages,
fully
merging
technology
innovative
shows
promise
successful
across
various
areas,
including
cancer
or
diseases.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 19, 2024
Abstract
Colorectal
cancer,
the
third
most
prevalent
cancer
globally,
contributes
significantly
to
mortality
rates,
with
over
1.9
million
reported
cases
and
nearly
935,000
fatalities
annually.
Surgical
resection
is
a
primary
approach
for
localized
colorectal
tumors,
adjunct
therapies
like
chemotherapy,
radiotherapy,
targeted/immunotherapy
considered
depending
on
tumor
stage.
However,
despite
preferences
targeted
immunotherapy
post-surgery,
chemotherapy
remains
commonly
chosen
due
its
lower
cost
high
cancer-killing
efficiency.
Yet,
faces
issues
such
as
resistance
severe
side
effects.
Nanotechnology
has
emerged
in
therapy
by
alleviating
drawbacks
of
current
treatment
approaches.
In
past
few
decades,
inorganic
nanoparticles
have
shown
promise
combating
offering
advantages
conventional
chemotherapy.
Compared
organic
nanoparticles,
exhibit
properties
photosensitivity,
conductivity,
magnetic
allure,
thermal
proficiency,
allowing
them
function
both
drug
carriers
therapeutic
agents.
Derived
primarily
from
carbon,
silica,
metals,
metal
oxides,
they
offer
superior
drug-loading
capacity,
heightened
quantum
yield,
participation
advanced
photothermal
photodynamic
therapies.
This
review
provides
brief
overview
pathophysiology
pivotal
role
therapy,
delivery.
Additionally,
it
discusses
numerous
based
recent
literature.
Graphical
abstract
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 12889 - 12937
Published: Dec. 1, 2024
Abstract:
Over
the
last
decade,
biomedical
nanomaterials
have
garnered
significant
attention
due
to
their
remarkable
biological
properties
and
diverse
applications
in
biomedicine.
Metal
oxide
nanoparticles
(NPs)
are
particularly
notable
for
wide
range
of
medicinal
uses,
including
antibacterial,
anticancer,
biosensing,
cell
imaging,
drug/gene
delivery.
Among
these,
zinc
(ZnO)
NPs
stand
out
versatility
effectiveness.
Recently,
ZnO
become
a
primary
material
various
sectors,
such
as
pharmaceutical,
cosmetic,
antimicrobials,
construction,
textile,
automotive
industries.
can
generate
reactive
oxygen
species
induce
cellular
apoptosis,
thus
underpinning
potent
anticancer
antibacterial
properties.
To
meet
growing
demand,
numerous
synthetic
approaches
been
developed
produce
NPs.
However,
traditional
manufacturing
processes
often
involve
economic
environmental
costs,
prompting
search
more
sustainable
alternatives.
Intriguingly,
synthesis
methods
utilizing
plants,
plant
extracts,
or
microorganisms
emerged
ideal
producing
These
green
production
techniques
offer
medicinal,
economic,
environmental,
health
benefits.
This
review
highlights
latest
advancements
applications,
showcasing
potential
revolutionize
field
with
eco-friendly
cost-effective
solutions.
Keywords:
antimicrobial,
antioxidant,
synthesis,
nanomedicine,
nanoparticle,
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1120 - 1120
Published: Aug. 24, 2024
Natural
photosensitizers
(PS)
are
compounds
derived
from
nature,
with
photodynamic
properties.
PSs
have
a
similar
action
to
that
of
commercial
PSs,
where
cancer
cell
death
occurs
by
necrosis,
apoptosis,
and
autophagy
through
ROS
generation.
garnered
great
interest
over
the
last
few
decades
because
their
high
biocompatibility
good
photoactivity.
Specific
wavelengths
could
cause
phytochemicals
produce
harmful
for
therapy
(PDT).
However,
natural
some
shortcomings,
such
as
reduced
solubility
lower
uptake,
making
them
less
appropriate
PDT.
Nanotechnology
offers
an
opportunity
develop
suitable
carriers
various
PDT
applications.
Various
nanoparticles
been
developed
improve
outcome
enhanced
solubility,
optical
adsorption,
tumor
targeting.
Multidrug
resistance
(MDR)
is
phenomenon
in
which
cells
wide
range
structurally
functionally
unrelated
drugs.
Over
decade,
several
researchers
extensively
studied
effect
PS-based
treatment
(PDT)
on
MDR
cells.
Though
outcomes
clinical
trials
were
inconclusive,
significant
advancement
still
required
before
can
be
used
agent
treating
tumors.
This
review
addresses
increasing
literature
progression
efficacy
PDT,
emphasizing
importance
developing
new
nano-based
fight
against
features
photosensitizing
regimen.
Advanced Therapeutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 19, 2025
Abstract
Inflammatory
bowel
disease
(IBD)
is
a
complex
chronic
inflammatory
disorder
of
the
gastrointestinal
(GI)
tract
with
an
uncertain
etiology.
Currently,
IBD
therapy
relies
on
induction
clinical
remission
followed
by
maintenance
using
anti‐inflammatory
drugs
and
immunosuppressants;
however,
definite
cure
still
out
scope.
Established
approaches
are
characterized
adverse
drug‐related
side
effects
that
can
even
be
potentially
life‐threatening.
In
contrast,
increased
interest
remarkable
scientific
progress
in
targeted
drug
delivery
systems
offer
promising
approach
to
reduce
systemic
events,
delivering
therapeutic
substances
only
inflamed
tissue.
All
alteration
barrier
integrity,
especially
disturbed
epithelial
barrier,
unique
pattern
receptors
cell
surface
and/or
oxidative
stress
milieu
areas
used
as
effective
for
controlled
delivery.
Hence,
this
review
focuses
pathophysiology
GI
potential
strategy
polymeric
nanoparticles
treatment.
Interdisciplinary
efforts
between
chemistry
gastroenterology/immunology
promise
create
novel
synergies
improve
development
nanoparticle
significant
impact.
regard,
current
challenges
translation
nanomedicine
also
discussed.
