Overview of Recent Advances in Nano-Based Ocular Drug Delivery

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15352 - 15352

Published: Oct. 19, 2023

Ocular diseases profoundly impact patients’ vision and overall quality of life globally. However, effective ocular drug delivery presents formidable challenges within clinical pharmacology biomaterial science, primarily due to the intricate anatomical physiological barriers unique eye. In this comprehensive review, we aim shed light on features eye, emphasizing natural it administration. Our goal is provide a thorough overview various characteristics inherent each nano-based system. These encompass nanomicelles, nanoparticles, nanosuspensions, nanoemulsions, microemulsions, nanofibers, dendrimers, liposomes, niosomes, nanowafers, contact lenses, hydrogels, microneedles, innovative gene therapy approaches employing techniques. We delve into biology methodology these systems, introducing their applications over past decade. Furthermore, discuss advantages illuminated by recent studies. While systems for ophthalmic formulations are gaining increasing attention, further research imperative address potential safety toxicity concerns.

Language: Английский

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Nanoparticle-based delivery systems as emerging therapy in retinoblastoma: recent advances, challenges and prospects

Nanoscale Advances, Journal Year: 2023, Volume and Issue: 5(18), P. 4628 - 4648

Published: Jan. 1, 2023

Nanoparticles utilized in targeting retinoblastoma cells demonstrated improved uptake and intracellular internalization, sustained retention, excellent cytotoxicity, enhanced apoptosis antitumor activity.

Language: Английский

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A primer on food and drug administration's approval process

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 349 - 358

Published: Jan. 1, 2025

Language: Английский

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LNP-encapsulated miRNA29b for Corneal Repair: A Novel Approach to Combat Fibrosis

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101695 - 101695

Published: March 1, 2025

Language: Английский

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Protective Encapsulation of a Bioactive Compound in Starch–Polyethylene Glycol-Modified Microparticles: Degradation Analysis with Enzymes

Polymers, Journal Year: 2024, Volume and Issue: 16(14), P. 2075 - 2075

Published: July 20, 2024

Starch is a promising polymer for creating novel microparticulate systems with superior biocompatibility and controlled drug delivery capabilities. In this study, we synthesized polyethylene glycol (PEG)-modified starch microparticles encapsulated folic acid using solvent-mediated acid-base precipitation method magnetic stirring, which simple effective method. To evaluate particle degradation, simulated physiological conditions by employing an enzymatic degradation approach. Our results FTIR SEM confirmed the successful synthesis of starch–PEG encapsulating acid. The average size was 4.97 μm increased to 6.01 upon modification PEG. were first exposed amylase at pH 6.7 pepsin 1.5 different incubation times temperature shaking. Post-degradation analysis revealed changes in morphology, indicating degradation. spectroscopy used assess chemical composition before after initial spectra displayed characteristic peaks starch, PEG, acid, showed decreased intensities suggesting alterations composition. These findings demonstrate ongoing development other biomedical applications provide basis further exploration PEG–starch as versatile biomaterial bioactive compounds.

Language: Английский

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Nanobiohybrids and Bacterial Carriers: A Novel Pathway to Targeted Cancer Therapy

Nano Futures, Journal Year: 2024, Volume and Issue: 8(3), P. 032001 - 032001

Published: Sept. 1, 2024

Abstract The new strategies in this regard of nanotechnology and biotechnology guarantee new, efficient modalities for cancer therapy. In study, we explore nanobiohybrids, the bacterium-targeted treatment approach that presents a category therapeutic carriers treating cancer. We specifically focus on bacteriomimetics, where bacteria are used as natural agents. These possess ability pathotropism localizing themselves around tumor tissues, even hypoxic areas generally refractory to standard therapies. By engineering surface these bacteria, enhance how they target cells so is delivered microenvironment with no or minimal systemic side effects. Furthermore, synthetic nanoparticles inculcated into bacterial systems stabilize drugs also provide way controlled release, which important maintain effectiveness. Our results established such nanobiohybrids capable delivery chemotherapeutic agents conducting local real-time response from perspective personalized treatment. This research implies huge development targeted therapy against cancer, further work has focused optimizing biohybrid clinical applications.

Language: Английский

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Current Insights on Lipid-Based Nanosystems 2023

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(12), P. 1700 - 1700

Published: Dec. 8, 2023

Among the different types of nanosystems that have been investigated for therapeutic use, lipid-based ones are most explored, as they advantages over non-lipid nanosystems, especially improving transport and efficacy drugs through routes administration, such ocular, cutaneous, intranasal, intravenous [...].

Language: Английский

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Eyes on the Prize: Decoding the Ophthalmic Product Regulations and Intricacies of the U.S. Food and Drug Administration Approval

Journal of Ocular Pharmacology and Therapeutics, Journal Year: 2023, Volume and Issue: 39(8), P. 572 - 582

Published: Oct. 1, 2023

The dynamic and continuously evolving field of ophthalmology necessitates rigorous regulatory oversight in the United States. This review outlines multifaceted Food Drug Administration's (FDA) approval process for ophthalmic products, detailing classifications, pathways, compliance devices, drugs, biologics, combination products. Particular emphasis is placed on distinct frameworks Class I, II, III as well regulations organizational structure FDA detailed, with highlights specific Ophthalmology divisions, historical evolution, initiatives such Patient-Focused Development. An in-depth examination journey, ranging from initial research to post-marketing surveillance, includes practical guidance through stages Pre-Investigational New Drug/Pre-Submission consultations, clinical trials, new drug application/biologics license application/premarket submissions, advisory committee interactions. article underscores importance early interactions health authorities, interdisciplinary team collaboration, adherence current standards, anticipation policy changes ensure patient safety. It concludes an analysis 4 key FDA-approved including Eylea®, Luxturna®, Alphagan P®, Raindrop® Near Vision Inlay, their contributions care offering valuable insights into respective potential implications. These case studies are included illustrate both successful failed product launches, thereby highlighting alignment compliance.

Language: Английский

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Detection of Pre-Existing Antibodies to Polyethylene Glycol and PEGylated Liposomes in Human Serum

Methods in molecular biology, Journal Year: 2024, Volume and Issue: unknown, P. 185 - 192

Published: Jan. 1, 2024

Language: Английский

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Comparative analysis of lipid-peptide nanoparticles prepared via microfluidics, reverse phase evaporation, and ouzo techniques for efficient plasmid DNA delivery

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 201, P. 114385 - 114385

Published: June 28, 2024

Language: Английский

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