Unlocking the potential: very-low-energy ketogenic therapy in obesity-related disorders

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: Jan. 16, 2025

The Very Low-Energy Ketogenic Therapy (VLEKT) is a structured, multi-phase dietary regimen characterized by carbohydrate intake of less than 50 g/day and daily caloric fewer 800 kcal, which induces ketosis facilitates significant weight loss. Evidence suggests that this nutritional therapy can improve glycemic control, lipid profiles, blood pressure, making it promising option for managing type 2 diabetes (T2D) reducing cardiovascular risk. These benefits are achieved through reductions in triglycerides low-density lipoprotein cholesterol (LDL-c), alongside increases high-density (HDL-c). However, the effects VLEKT on metabolism remain controversial. review emphasizes urgent need further research to validate long-term safety efficacy VLEKT. It also highlights critical role personalized plans, supervised healthcare professionals, optimize health outcomes address individual patient needs.

Language: Английский

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Long-Term Efficacy and Safety of Nutritional and Pharmacological Strategies for Obesity

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 3, 2025

Language: Английский

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Future perspectives for PDE5 inhibitors bridging the gap between cardiovascular health and psychological status

Basic and Clinical Andrology, Journal Year: 2025, Volume and Issue: 35(1)

Published: Jan. 26, 2025

Abstract The serendipitous discovery that inhibiting type 5 phosphodiesterase (PDE5) using sildenafil, a potent PDE5 inhibitor (PDE5i) initially developed for cardioprotection, introduced the possibility of orally managing erectile dysfunction (ED) led to an increase in research data, which are currently considered groundbreaking new discipline sexual medicine. Findings from number laboratories and clinics around world unanimously demonstrated following: (i) major cause ED is directly or indirectly related cardiovascular disease (CVD); (ii) CVDs share same risk factors, mainly lifestyle choices; (iii) first therapeutic approach both transform harmful lifestyles into virtuous lifestyles; (iv) PDE5is general, particularly very safe, if not protective, use CVD patients. However, has faced several challenges. Many patients some healthcare providers (HCPs) often misconception these drugs can CVD. Some might desire fulfill unmet need privacy linked stigma being treated be enticed by idea buying online, either because shame cheaper prices, without knowing risks associated with counterfeit drugs. aim this narrative revision current literature demonstrate orodispersible film sildenafil safe CV perspective; it discreet formulation respects privacy; virtually unique PDE5i too expensive produce outside correct channels, making impossible counterfeit.

Language: Английский

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Optimal Diet Strategies for Weight Loss and Weight Loss Maintenance

Journal of Obesity & Metabolic Syndrome, Journal Year: 2020, Volume and Issue: 30(1), P. 20 - 31

Published: Oct. 27, 2020

Obesity has become one of the most important public health problems worldwide, which suggests need for evidence-based dietary strategies weight loss and its maintenance. Weight management depends upon complex factors such as amount food eaten, type timing meals. In this review, we identified based on these three components. An energy deficit is factor in loss. A low-calorie diet with a low fat or carbohydrate content been recommended; however, some cases, very-low-calorie required short period. Some macronutrient composition-based diets, ketogenic high-protein diet, could be considered although potential risks long-term effectiveness remain unknown. Meal also an management, higher-calorie breakfasts combination overnight fasting may help to prevent obesity. Our review indicated that there no single best strategy management. Hence, maintenance should individualized, healthcare providers must choose patient preferences.

Language: Английский

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Diet approach before and after bariatric surgery

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2020, Volume and Issue: 21(3), P. 297 - 306

Published: July 30, 2020

Abstract Bariatric surgery (BS) is today the most effective therapy for inducing long-term weight loss and reducing comorbidity burden mortality in patients with severe obesity. On other hand, BS may be associated to new clinical problems, complications side effects, particular nutritional domain. Therefore, management of bariatric requires specific skills. In this paper, a brief overview will provided from pre-operative post-operative phase. Patients obesity often display micronutrient deficiencies when compared normal controls. status should checked every patient correction attempted before surgery. At present, evidences randomized retrospective studies do not support hypothesis that could improve after surgery, insurance-mandated policy preoperative as pre-requisite admission supported by medical evidence. contrary, some suggest modest 5–10% immediate period facilitate reduce risk complications. Very low calories diet (VLCD) very ketogenic diets (VLCKD) are frequently used methods induction today. After counselling recommended order adaptation eating habits gastro-intestinal physiology. Nutritional deficits arise according type procedure they prevented, diagnosed eventually treated. Finally, like dumping syndrome reactive hypoglycaemia, can occur managed largely manipulation. conclusion, skills intervention experienced nutritionists dieticians.

Language: Английский

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Very-Low-Calorie Ketogenic Diets With Whey, Vegetable, or Animal Protein in Patients With Obesity: A Randomized Pilot Study

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2020, Volume and Issue: 105(9), P. 2939 - 2949

Published: June 2, 2020

Abstract Context We compared the efficacy, safety, and effect of 45-day isocaloric very-low-calorie ketogenic diets (VLCKDs) incorporating whey, vegetable, or animal protein on microbiota in patients with obesity insulin resistance to test hypothesis that source may modulate response VLCKD interventions. Subjects Methods Forty-eight (19 males 29 females, homeostatic model assessment (HOMA) index ≥ 2.5, aged 56.2 ± 6.1 years, body mass [BMI] 35.9 4.1 kg/m2) were randomly assigned three regimens (≤800 kcal/day) containing plant, protein. Anthropometric indexes; blood urine chemistry, including parameters kidney, liver, glucose, lipid metabolism; composition; muscle strength; taxonomic composition gut microbiome assessed. Adverse events also recorded. Results Body weight, BMI, pressure, waist circumference, HOMA index, insulin, total low-density lipoprotein cholesterol decreased all patients. Patients who consumed whey had a more pronounced improvement strength. The markers renal function worsened slightly group. A decrease relative abundance Firmicutes an increase Bacteroidetes observed after consumption VLCKDs. This pattern was less consuming Conclusions VLCKDs led significant weight loss striking metabolic over period. based vegetable have safer profile result healthier than those proteins. are effective maintaining performance.

Language: Английский

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Efficacy of a 2-Month Very Low-Calorie Ketogenic Diet (VLCKD) Compared to a Standard Low-Calorie Diet in Reducing Visceral and Liver Fat Accumulation in Patients With Obesity

Frontiers in Endocrinology, Journal Year: 2020, Volume and Issue: 11

Published: Sept. 14, 2020

BBackground: Currently the treatment of nonalcoholic fatty liver disease (NAFLD) is based on weight loss through lifestyle changes, such as exercise combined with calorie-restricted dieting. Objectives: To assess effects a commercially available program Very Low-Calorie Ketogenic Diet (VLCKD) Visceral Adipose Tissue (VAT) and fat content compared to standard diet (LC). As secondary aim we evaluated effect stiffness measurements. Methods: Open, randomized, controlled, prospective pilot study. Patients were randomized treated either LC or VLCKD received orientation encouragement physical activity equally for both groups. VAT, fraction measured at baseline after 2 months using Magnetic Resonance Imaging (MRI). Paired t-tests used comparison continuous variables between visits unpaired test Categorical Chi-squared test. Pearson's correlation was association anthropometric measures hepatic fraction. A significance level results established p<0.05. Results: 39 patients (20 19 LC) intervention. Relative -9.59 ± 2.87 % in group -1.87 2.4 (p<0.001). Mean reductions VAT -32.0 cm2 -12.58 (p<0.05). Reductions significantly more pronounced than (4.77% vs 0.79%; p<0.005). Conclusion: undergoing achieved superior loss, significant when low-calorie diet. The rapid mobilization demonstrated VLCKD, could serve an effective alternative NAFLD.

Language: Английский

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Regulation of GH and GH Signaling by Nutrients

Cells, Journal Year: 2021, Volume and Issue: 10(6), P. 1376 - 1376

Published: June 2, 2021

Growth hormone (GH) and insulin-like growth factor-1 (IGF-I) are pleiotropic hormones with important roles in lifespan. They promote growth, anabolic actions, body maintenance, conditions of energy deprivation, favor catabolic feedback mechanisms switching from carbohydrate oxidation to lipolysis, the aim preserve protein storages survival. IGF-I/insulin signaling was also first one identified regulation lifespan relation nutrient-sensing. Indeed, nutrients crucial modifiers GH/IGF-I axis, these regulate complex orchestration utilization cell tissues. The this review is summarize current knowledge on reciprocal among macro micronutrients, dietary regimens, including caloric restriction. Expanding depth information topic could open perspectives nutrition management, prevention, treatment deficiency or excess during life.

Language: Английский

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Scientific evidence underlying contraindications to the ketogenic diet: An update

Obesity Reviews, Journal Year: 2020, Volume and Issue: 21(10)

Published: July 10, 2020

Summary First identified as a feasible treatment for intractable epilepsy, the ketogenic diet (KD) has recently gained popularity thanks to growing evidence on applications such weight loss, most importantly, but also NAFLD, cancer, neurologic conditions and chronic pain. As with any treatment, whether pharmacologic or not, KD might not be an appropriate intervention every individual, number of contraindications have been proposed, now deeply rooted into clinical practice, excluding de facto many patients that could benefit from its use. However, these concerns were expressed due absence studies conducted fragile populations, assessment lately emerged relative safety is currently lacking much needed. We herein provide critical revision literature behind each alert, in order guide through options case subjects indication borderline safe situation. Based available evidence, possible use this therapeutic should assessed patient‐to‐patient basis by adequately skilled medical doctors, keeping mind current recommendations, reading them knowledge state art.

Language: Английский

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Effect of Very-Low-Calorie Ketogenic Diet on Psoriasis Patients: A Nuclear Magnetic Resonance-Based Metabolomic Study

Journal of Proteome Research, Journal Year: 2020, Volume and Issue: 20(3), P. 1509 - 1521

Published: Nov. 9, 2020

Psoriasis is an inflammatory disease of the epidermis based on immunological mechanism involving Langerhans cells and T lymphocytes that produce pro-inflammatory cytokines. Genetic factors, environmental improper nutrition are considered triggers disease. Numerous studies have reported in a high number patients, psoriasis associated with obesity. Excess adipose tissue, typical obesity, causes systemic status coming from active tissue; therefore, weight reduction strategy to fight this state. This study aimed evaluate how nutritional regimen ketogenic diet influenced clinical parameters, metabolic profile, state patients. To end, 30 patients were subjected monitored for 4 weeks by evaluating data, biochemical NMR metabolomic IL-2, IL-1β, TNF-α, IFN-γ, IL-4 concentrations before after regimen. Our data show low-calorie can be successful therapeutic option gain improvement psoriasis-related dysmetabolism, significant correction full status.

Language: Английский

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