The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

EMBO Molecular Medicine, Journal Year: 2021, Volume and Issue: 14(1)

Published: Nov. 15, 2021

Language: Английский

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Mediterranean Diet and Obesity-related Disorders: What is the Evidence?

Current Obesity Reports, Journal Year: 2022, Volume and Issue: 11(4), P. 287 - 304

Published: Sept. 30, 2022

Abstract Purpose of Review Obesity is a chronic disease, major public health problem due to its association with non-communicable diseases and all-cause mortality. Indeed, people obesity are at increased risk for variety obesity-related disorders including hypertension, dyslipidemia, type 2 diabetes mellitus, cardiovascular several cancers. Many popular diets very different macronutrient composition, the Mediterranean diet (MD), have been used, proposed, studied prevention management obesity. In particular, MD has subject countless studies over years now boasts large body scientific literature. this review, we aimed update current knowledge by summarizing most recent evidence on effect disorders. Recent Findings The negative effects partly reversed substantial weight loss that can be achieved MD, especially when low-calorie in combination adequate physical activity. addition, composition correlated an excellent reducing dyslipidemia. It also positively modulates gut microbiota immune system, significantly decreasing inflammatory mediators, common ground many Summary People medical disease. Therefore, there inevitable need measures manage related At point, proposed as valuable nutritional intervention. characterized high consumption vegetables, fruit, nuts, cereals, whole grains, extra virgin olive oil, well moderate fish poultry, limited intake sweets, red meat, dairy products. proves healthiest dietary pattern available tackle prevent diseases, disease diabetes.

Language: Английский

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Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(10), P. 1486 - 1498.e7

Published: Oct. 1, 2022

Language: Английский

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Ketogenic nutritional therapy (KeNuT)—a multi-step dietary model with meal replacements for the management of obesity and its related metabolic disorders: a consensus statement from the working group of the Club of the Italian Society of Endocrinology (SIE)—diet therapies in endocrinology and metabolism

Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: 47(3), P. 487 - 500

Published: Jan. 18, 2024

Abstract Purpose The ketogenic nutritional therapy (KeNuT) is an effective dietary treatment for patients with obesity and obesity-related comorbidities, including type 2 diabetes, dyslipidaemia, hypertension, coronary artery disease, some of cancers. However, to date official document on the correct prescription diet, validated by authoritative societies in nutrition or endocrine sciences, missing. It important emphasize that requires proper medical supervision patient selection, due complex biochemical implications ketosis need a strict therapeutic compliance, experienced nutritionist personalization whole protocol. Methods This practical guide provides update main clinical indications contraindications meal replacements its mechanisms action. In addition, various phases protocol involving replacements, monitoring, management potential side effects, are also discussed. Conclusion will help healthcare provider acquire necessary skills provide comprehensive care overweight, diseases, using multistep treatment, recognized Club Italian Society Endocrinology (SIE)—Diet Therapies Metabolism.

Language: Английский

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Meal timing and its role in obesity and associated diseases

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: March 22, 2024

Meal timing emerges as a crucial factor influencing metabolic health that can be explained by the tight interaction between endogenous circadian clock and homeostasis. Mistimed food intake, such delayed or nighttime consumption, leads to desynchronization of internal is associated with an increased risk for obesity disturbances type 2 diabetes cardiovascular diseases. Conversely, meal aligned cellular rhythms optimize performance tissues organs. In this review, we provide overview effects discuss underlying mechanisms. Additionally, explore factors timing, including determinants chronotype genetics, well external influences like social factors, cultural aspects, work schedules. This review could contribute defining meal-timing-based recommendations public initiatives developing guidelines effective lifestyle modifications targeting prevention treatment Furthermore, it sheds light on must considered in design future intervention trials.

Language: Английский

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Pork Meat Composition and Health: A Review of the Evidence

Foods, Journal Year: 2024, Volume and Issue: 13(12), P. 1905 - 1905

Published: June 17, 2024

Meat has been part of the human diet for centuries and it is a recognizable source high-biologic-value protein several micronutrients; however, its consumption associated with an increased risk non-communicable diseases (e.g., cardiovascular diseases, cancer). These concerns are mostly related to red meat. However, meat composition quite variable within species cuts. The present study explores pork meat, differences among different cuts reviews evidence on influence health outcomes. Pork contributes 30% all consumed worldwide offers distinct nutrient profile; rich in high-quality protein, B-complex vitamins, essential minerals such as zinc iron, though contains moderate levels saturated fat compared beef. Additionally, research sustainability points out advantages from considering that non-ruminant animal included one five more sustainable dietary patterns. In what data outcomes, few clinical studies have shown no harmful effects factors, specifically blood lipids. Several arguments can justify be option healthy diet.

Language: Английский

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Comparison of the Efficacy of Anti-Obesity Medications in Real-World Practice

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 845 - 858

Published: March 1, 2024

Anti-obesity medications (AOMs), along with lifestyle interventions, are effective means of inducing and maintaining weight loss in patients obesity. Although the efficacy AOMs has been reported, there have no direct comparisons these drugs. Therefore, present study, we aimed to compare all available Korea a real-world setting.

Language: Английский

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Effectiveness of Early Versus Late Time-Restricted Eating Combined with Physical Activity in Overweight or Obese Women

Nutrients, Journal Year: 2025, Volume and Issue: 17(1), P. 169 - 169

Published: Jan. 2, 2025

Aims: To evaluate the effectiveness of a dual approach involving time-restricted eating (TRE) at different times day combined with physical activity (PA) on functional capacity and metabolic health in overweight or obese women. Methods: Random allocation sixty-one participants into four groups: early plus (ETRE-PA, n = 15, 31.8 ± 10.76 years, 89.68 13.40 kg, 33.5 5.53 kg/m2), late (LTRE-PA, 30.60 7.94 94.45 15.36 34.37 7.09 only (LTRE, 27.93 9.79 88.32 10.36 32.71 5.15 kg/m2) control group (CG, 36.25 11.52 89.01 11.68 33.66 6.18 kg/m2). The intervention lasted for 12 weeks all groups. Both ETRE-PA LTRE-PA groups engaged rigorous aerobic resistance-training program. Results: Significant reductions body weight mass index were observed compared to CG LTRE post-intervention (p < 0.0005). Only exhibited significant decrease fat 0.02), low-density lipoprotein cholesterol 0.01), aspartate aminotransferase 0.002). alanine levels 0.004) 0.02) These two latter achieved higher performances 6-min walking test, bench press, 30-s squat, crunch vertical jump 0.0005 both), leg extension 0.02 both) when Conclusion: integration TRE PA leads greater improvements composition, lipid profile, performance, no differences between approaches. This strategy offers promising solution

Language: Английский

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Vorbeugen ist besser als heilen: Präventionsstrategien für Arthrose

MSK – Muskuloskelettale Physiotherapie, Journal Year: 2025, Volume and Issue: 29(01), P. 17 - 26

Published: Feb. 1, 2025

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Mediterranean Diet versus Very Low-Calorie Ketogenic Diet: Effects of Reaching 5% Body Weight Loss on Body Composition in Subjects with Overweight and with Obesity—A Cohort Study

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(20), P. 13040 - 13040

Published: Oct. 11, 2022

The best nutritional strategy to fight the rise in obesity remains a debated issue. Mediterranean diet (MD) and Very Low-Calorie Ketogenic (VLCKD) are effective at helping people lose body weight (BW) fat mass (FM) while preserving fat-free (FFM). This study aimed evaluate time these two diets took reach loss of 5% initial BW how composition was affected. We randomized 268 subjects with or overweight arms, MD VLCKD, for maximum 3 months until they reached loss. result achieved after one month VLCKD MD. Both were terms (p < 0.0001) FM 0.0001), but higher reduction both waist circumference = 0.0010) 0.0006) greater increase total water 0.0017) FFM 0.0373) than VLCKD. population also stratified according gender, age, BMI. These protocols improving anthropometrical parameters composition, take different spans goal. Therefore, professionals should which is most suitable each patient’s health status.

Language: Английский

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